About

David Hogness was a founding faculty member at Stanford University's Department of Biochemistry. His pioneering work has been commemorated through two articles published in GENETICS on his 100th birthday, highlighting his significant contributions to the field. His research focus and specific scientific achievements are not detailed on the page, but his legacy is recognized as influential within the scientific community.

Research topics

• Biology
• Genetics
• Cell biology
• Molecular biology
• Chemistry

Selected publications

• Mechanism of DNA Replication in Drosophila Chromosomes: Structure of Replication Forks and Evidence for Bidirectionality (electron microscopy/Okazaki fragments/cleavage nuclei/branch migration/fork rate)

  2016-01-01

  articleSenior author

  The replicating chromosomlall DNA in Drosophila melanogaster cleavage nuclei has been visual- ized in the electron microscope as a serial array of closely spaced replicated regions created by pairs of diverging replication forks. The fine structure of the forks is very similar to that observed for the replication forks of bi- directionally replicating bacteriophage DNAs. However, the mean length of the single-stranded gaps in Drosophila forks is less than 200 nucleotide residues, much shorter than the gaps in phage forks. This difference in gap length corresponds to the observed difference in the size of Okazaki fragments from Drosophila and phage. The pleasing concept that the genetic information in a eukaryotic chromosome is contained in a single rmolecule of double-stranded DNA is supported by recent experiments with Drosophila (1) and yeast (2, 3). Given such a molecular continuity, the problem of reproducing the genetic order in a chromosome is reduced to the problem of replicating a single long DNA molecule which, for the largest chromosome in the fruit fly, Drosophila melanogaster, has a length of' about 2.1 cm., or 62,000 kb (ref. 1; kb (kilo bases) is a unit of length equal to 1000 bases or base pairs in single-stranded or double- stranded nucleic acids). We have studied this replication problem in D. melanogaster by electron microscopic examination of the DNA from rapidly dividing cleavage nuclei. At 24°, the cleavage nuclei divide every 9.6 min and exhibit an interphase of only 3.4 miii (4),

  Publisher

• Discoveries Interview: Professor Greg Gibson on the genomics revolution

  Discoveries · 2015-12-31

  articleOpen access

  Interview article with Professor Greg Gibson, a Professor in the School of Biology at the Georgia Institute of Technology, Atlanta, Georgia, USA, where he directs the Center for Integrative Genomics. Prof. Gibson is a human evolutionary quantitative geneticist, known for his work on the contributions of cryptic genetic variation and canalization on evolution and disease.

  PublisherOA PDFDOI

• Molecular Genetics of the Bithorax Complex in Drosophila Melanogaster

  2007-01-01 · 20 citations

  book-chapterSenior author
  PublisherDOI

• Molecular Genetics of the Bithorax Complex in Drosophila Melanogaster

  2004-01-01 · 16 citations

  book-chapterSenior author
  PublisherDOI

• L63, the Drosophila PFTAIRE, interacts with two novel proteins unrelated to cyclins

  Mechanisms of Development · 2003-04-05 · 10 citations

  articleSenior author
  PublisherDOI

• The 2003 Thomas Hunt Morgan Medal

  2003-01-01 · 2 citations

  article1st authorCorresponding
  Publisher

• The L63 Gene Is Necessary for the Ecdysone-Induced 63E Late Puff and Encodes CDK Proteins Required for Drosophila Development

  Developmental Biology · 2000-05-01 · 37 citations

  articleSenior authorCorresponding
  PublisherDOI

• Molecular Chaperones Activate the Drosophila Ecdysone Receptor, an RXR Heterodimer

  Cell · 2000-03-01 · 150 citations

  articleOpen accessSenior authorCorresponding
  PublisherOA PDFDOI

• Microarray Analysis of <i>Drosophila</i> Development During Metamorphosis

  Science · 1999-12-10 · 465 citations

  articleSenior author

  Metamorphosis is an integrated set of developmental processes controlled by a transcriptional hierarchy that coordinates the action of hundreds of genes. In order to identify and analyze the expression of these genes, high-density DNA microarrays containing several thousand Drosophila melanogaster gene sequences were constructed. Many differentially expressed genes can be assigned to developmental pathways known to be active during metamorphosis, whereas others can be assigned to pathways not previously associated with metamorphosis. Additionally, many genes of unknown function were identified that may be involved in the control and execution of metamorphosis. The utility of this genome-based approach is demonstrated for studying a set of complex biological processes in a multicellular organism.

  PublisherDOI

• Coordination of <i>Drosophila</i> Metamorphosis by Two Ecdysone-Induced Nuclear Receptors

  Science · 1997-04-04 · 301 citations

  articleSenior authorCorresponding

  The functions of the ecdysone-induced DHR3 and E75B orphan nuclear receptors in the early stages of Drosophila metamorphosis were investigated. DHR3 represses the ecdysone induction of early genes turned on by the pulse of ecdysone that triggers metamorphosis. It also induces betaFTZF1, an orphan nuclear receptor that is essential for the appropriate response to the subsequent prepupal pulse of ecdysone. The E75B receptor, which lacks a complete DNA binding domain, inhibits this inductive function by forming a complex with DHR3 on the betaFTZF1 promoter, thereby providing a timing mechanism for betaFTZF1 induction that is dependent on the disappearance of E75B.

  PublisherDOI

Recent grants

• NIH Grant R01GM045355

  NIH · $691k · 1995

Frequent coauthors

• William S. Talbot

  Stanford University

  15 shared

• Michael Bender

  10 shared

• William A. Segraves

  Yale University

  7 shared

• Pierre Spierer

  University of Geneva

  7 shared

• Carl S. Thummel

  University of Utah

  7 shared

• Welcome Bender

  Harvard University

  7 shared

• Philip A. Beachy

  Stanford University

  7 shared

• Elliot M. Meyerowitz

  6 shared

Labs

• David Hogness LabPI

Awards & honors

• Celebrating Dr. David S. Hogness’s Legacy: Two GENETICS Arti…