Erez Lieberman Aiden

About

Erez Lieberman Aiden, Ph.D., is a Professor and Chair of the Department of Biochemistry and Molecular Biology at the University of Texas Medical Branch, where he directs the Center for Genome Architecture. He is also a Professor in the Department of Biosciences at Rice University. His work focuses on understanding the three-dimensional structure of the genome and its implications for biology and disease. As the principal investigator of the Aiden Lab, he leads a team that applies experimental and computational approaches to study genome architecture, including the analysis of chromatin structure and gene regulation. His leadership at the Center for Genome Architecture highlights his commitment to advancing knowledge in the field of genome organization and its functional consequences.

Research topics

• Biology
• Genetics
• Evolutionary biology
• Political Science
• Ecology
• Environmental ethics
• Botany
• Environmental science
• Public relations
• Zoology

Selected publications

• 3D genomics across the tree of life reveals condensin II as a determinant of architecture type

  Science · 2021 · 297 citations

  We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional (3D) genome architectures at the chromosome scale. Each type appears and disappears repeatedly during eukaryotic evolution. The type of genome architecture that an organism exhibits correlates with the absence of condensin II subunits. Moreover, condensin II depletion converts the architecture of the human genome to a state resembling that seen in organisms such as fungi or mosquitoes. In th…

  PublisherOA PDFDOI

• Convergent and complementary selection shaped gains and losses of eusociality in sweat bees

  Nature Ecology & Evolution · 2023 · 47 citations

  PublisherOA PDFDOI

• Three-dimensional genome architecture persists in a 52,000-year-old woolly mammoth skin sample

  Cell · 2024-07-01 · 31 citations

  articleOpen accessSenior authorCorresponding

  Analyses of ancient DNA typically involve sequencing the surviving short oligonucleotides and aligning to genome assemblies from related, modern species. Here, we report that skin from a female woolly mammoth (†Mammuthus primigenius) that died 52,000 years ago retained its ancient genome architecture. We use PaleoHi-C to map chromatin contacts and assemble its genome, yielding 28 chromosome-length scaffolds. Chromosome territories, compartments, loops, Barr bodies, and inactive X chromosome (Xi)…

  PublisherOA PDFDOI

• A chromosome-length genome assembly and annotation of blackberry ( <i>Rubus argutus</i> , cv. “Hillquist”)

  G3 Genes Genomes Genetics · 2022 · 31 citations

  Blackberries (Rubus spp.) are the fourth most economically important berry crop worldwide. Genome assemblies and annotations have been developed for Rubus species in subgenus Idaeobatus, including black raspberry (R. occidentalis), red raspberry (R. idaeus), and R. chingii, but very few genomic resources exist for blackberries and their relatives in subgenus Rubus. Here we present a chromosome-length assembly and annotation of the diploid blackberry germplasm accession "Hillquist" (R. argutus).…

  PublisherOA PDFDOI

• Cohesin-mediated 3D contacts tune enhancer-promoter regulation

  bioRxiv (Cold Spring Harbor Laboratory) · 2024-07-12 · 29 citations

  preprintOpen access

  Enhancers are key drivers of gene regulation thought to act via 3D physical interactions with the promoters of their target genes. However, genome-wide depletions of architectural proteins such as cohesin result in only limited changes in gene expression, despite a loss of contact domains and loops. Consequently, the role of cohesin and 3D contacts in enhancer function remains debated. Here, we developed CRISPRi of regulatory elements upon degron operation (CRUDO), a novel approach to measure ho…

  PublisherOA PDFDOI

Frequent coauthors

• Olga Dudchenko

  Baylor College of Medicine

  880 shared

• Neva C. Durand

  362 shared

• Suhas S.P. Rao

  251 shared

• Eric S. Lander

  Broad Institute

  236 shared

• Arina D. Omer

  Baylor College of Medicine

  223 shared

• Muhammad S. Shamim

  201 shared

• David Weisz

  Baylor College of Medicine

  186 shared

• Michele Di Pierro

  Northeastern University

  122 shared

Labs

• Aiden LabPI

  The Center for Genome Architecture

Similar researchers at Rice University

• Bonnie Bartelh-76
• Daniel Carsonh-56
• Evan Siemannh-54