Elizabeth Seaquist

About

Dr. Takako Araki is an Associate Professor in the Division of Endocrinology, Diabetes and Metabolism at the University of Minnesota. Her research is dedicated to quality improvement of pituitary perioperative patient care and the management of pituitary disorders. She is actively involved in research related to pituitary development and disorders, with a focus on improving clinical outcomes for patients with these conditions. Her work contributes to advancing understanding and treatment of pituitary-related health issues, supporting the broader mission of the Araki Lab to investigate endocrine and metabolic disorders.

Research topics

• Endocrinology
• Medicine
• Internal medicine
• Pediatrics
• Pathology
• Intensive care medicine

Selected publications

• Prevalence of microvascular and macrovascular disease in the Glycemia Reduction Approaches in Diabetes - A Comparative Effectiveness (GRADE) Study cohort

  Diabetes Research and Clinical Practice · 2020 · 31 citations

  DOI

• Optimization of Metformin in the GRADE Cohort: Effect on Glycemia and Body Weight

  Diabetes Care · 2020 · 25 citations

  OBJECTIVE: We evaluated the effect of optimizing metformin dosing on glycemia and body weight in type 2 diabetes. RESEARCH DESIGN AND METHODS: during run-in. RESULTS: = 1,894). CONCLUSIONS: values ≥6.8% (51 mmol/mol). These findings may help guide efforts to optimize metformin therapy among persons with type 2 diabetes and suboptimal glycemic control.

  DOI

• Association of Baseline Factors With Glycemic Outcomes in GRADE: A Comparative Effectiveness Randomized Clinical Trial

  Diabetes Care · 2024-01-29 · 10 citations

  articleOpen access

  OBJECTIVE: To describe the individual and joint associations of baseline factors with glycemia, and also with differential effectiveness of medications added to metformin. RESEARCH DESIGN AND METHODS: Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) participants (with type 2 diabetes diagnosed for <10 years, on metformin, and with HbA1c 6.8-8.5%; N = 5,047) were randomly assigned to a basal insulin (glargine), sulfonylurea (glimepiride), glucagon-like peptide…

  PublisherOA PDFDOI

• BMI, insulin sensitivity, and cognition in early type 2 diabetes: The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study

  Obesity · 2023-06-27 · 7 citations

  articleOpen access

  OBJECTIVE: This study explored the association of BMI and insulin sensitivity with cognitive performance in type 2 diabetes. METHODS: A cross-sectional analysis of data from the baseline assessment of the Glycemia Reduction Approaches in Diabetes: a Comparative Effectiveness Study (GRADE) was conducted. BMI was used as a surrogate of adiposity and the Matsuda index as the measure of insulin sensitivity. Cognitive tests included the Spanish English Verbal Learning Test, the Digit Symbol Substitut…

  PublisherOA PDFDOI

• Glucose-Lowering Medications, Glycemia, and Cognitive Outcomes

  JAMA Internal Medicine · 2025-05-19 · 6 citations

  letterOpen access

  Importance: Type 2 diabetes (T2D) is a risk factor for cognitive impairment. Whether the choice of the second-line glucose-lowering treatment added to metformin or glycemic control affects cognitive performance in T2D of relatively short duration (<10 years) is not known. Objective: To compare the relative effect of 4 classes of glucose-lowering medications that were randomly added to metformin on cognitive performance and to examine the association of longitudinal glycemic levels with cognitive…

  PublisherOA PDFDOI

Recent grants

• NIH Grant R01DK095360

  NIH · $278k · 2015

• NIH Grant K08DK001920

  NIH · $419k · 1994

• NIH Grant M01RR000400

  NIH · $21.0M · 2010

Frequent coauthors

• E. Diaz

  Medical University of South Carolina

  276 shared

• M. Mullen

  262 shared

• Naji Younes

  Milken Institute

  194 shared

• Rodica Pop‐Busui

  Oregon Health & Science University

  160 shared

• Melissa Lee

  Otterbein University

  155 shared

• Mary Ann Banerji

  151 shared

• Emily B. Schroeder

  145 shared

• Richard M. Bergenstal

  Park Nicollet Clinic

  144 shared

Labs

• Araki LabPI

Awards & honors

• American Diabetes Association’s Transformative Woman in Diab…
• Albert Renold Award for Mentoring (2020)
• Inductee, AHC Academy for Excellence in Team Science, Univer…
• Bruce Zimmerman Diabetes Award, American Diabetes Associatio…
• Inductee, AHC Academy for Excellence in Health Research, Uni…

Similar researchers at University of Minnesota

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• Mahsa Abassih-34
• Stuart Amateauh-32