Elizabeth Neumann

About

Elizabeth Neumann is an Assistant Professor in the Chemistry Department at UC Davis, joining the department in the summer of 2022. Her research focuses on understanding the molecular and cellular architecture behind neurological diseases through highly interdisciplinary approaches. She develops analytical tools and multimodal imaging methods, utilizing matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) to measure hundreds to thousands of molecular features within biological samples without disturbing their spatial content. Her work involves coupling this chemically informative data with technologies such as highly multiplexed immunofluorescence, spectroscopy, and transcriptomics to provide a comprehensive understanding of complex biological systems. Neumann's background includes postdoctoral research at Vanderbilt University under Richard Caprioli and Jeffrey Spraggins, and a Ph.D. from the University of Illinois at Urbana-Champaign under Jonathan Sweedler. Her contributions include advancing molecular mapping in biology and medicine, with a particular emphasis on spatial metabolomics and lipidomics in tissues such as the human kidney and brain.

Research topics

• Chemistry
• Chromatography
• Artificial Intelligence
• Organic chemistry
• Computer Science
• Stereochemistry
• Materials science
• Medicine
• Computational biology
• Biology

Selected publications

• Strain‐Release Pentafluorosulfanylation and Tetrafluoro(aryl)sulfanylation of [1.1.1]Propellane: Reactivity and Structural Insight**

  Angewandte Chemie International Edition · 2022 · 75 citations

  Ar radicals across [1.1.1]propellane, we accessed structurally unique bicyclopentanes, bearing two distinct elements of bioisosterism. Upon evaluating these "hybrid isostere" motifs in the solid state, we measured exceptionally short transannular distances; in one case, the distance rivals the shortest nonbonding C⋅⋅⋅C contact reported to date. This prompted SC-XRD and DFT analyses that support the notion that a donor-acceptor interaction involving the "wing" C-C bonds is playing an important ro…

  PublisherOA PDFDOI

• Organ Mapping Antibody Panels: a community resource for standardized multiplexed tissue imaging

  Nature Methods · 2023-07-19 · 44 citations

  articleOpen access

  Multiplexed antibody-based imaging enables the detailed characterization of molecular and cellular organization in tissues. Advances in the field now allow high-parameter data collection (>60 targets); however, considerable expertise and capital are needed to construct the antibody panels employed by these methods. Organ mapping antibody panels are community-validated resources that save time and money, increase reproducibility, accelerate discovery and support the construction of a Human Refere…

  PublisherOA PDFDOI

• Sample Preparation Method for MALDI Mass Spectrometry Imaging of Fresh-Frozen Spines

  Analytical Chemistry · 2023-10-27 · 16 citations

  articleOpen accessSenior authorCorresponding

  Technologies assessing the lipidomics, genomics, epigenomics, transcriptomics, and proteomics of tissue samples at single-cell resolution have deepened our understanding of physiology and pathophysiology at an unprecedented level of detail. However, the study of single-cell spatial metabolomics in undecalcified bones faces several significant challenges, such as the fragility of bone, which often requires decalcification or fixation leading to the degradation or removal of lipids and other molec…

  PublisherDOI

• Optimized combination of MALDI MSI and immunofluorescence for neuroimaging of lipids within cellular microenvironments

  Frontiers in Chemistry · 2024-02-09 · 13 citations

  articleOpen accessSenior author

  Proper neurological function relies on the cellular and molecular microenvironment of the brain, with perturbations of this environment leading to neurological disorders. However, studying the microenvironments of neurological tissue has proven difficult because of its inherent complexity. Both the cell type and metabolomic underpinnings of the cell have crucial functional roles, thus making multimodal characterization methods key to acquiring a holistic view of the brain's microenvironment. Thi…

  PublisherOA PDFDOI

• Imaging and spatially resolved mass spectrometry applications in nephrology

  Nature Reviews Nephrology · 2025-03-27 · 7 citations

  review
  PublisherDOI

Frequent coauthors

• Jeffrey M. Spraggins

  Vanderbilt University

  105 shared

• Jamie Allen

  78 shared

• Danielle Gutierrez

  Vanderbilt University

  58 shared

• Raf Van de Plas

  Vanderbilt University

  42 shared

• Maya Brewer

  Vanderbilt University Medical Center

  41 shared

• Richard M. Caprioli

  Vanderbilt University

  40 shared

• Mark de Caestecker

  Vanderbilt University Medical Center

  32 shared

• Lukasz G. Migas

  Vanderbilt University

  30 shared

Education

• Graduate Student, Chemistry

  University of Illinois

  2018

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