About

Professor Edward Castillo is an Associate Professor and Associate Chair for Graduate Education in the Department of Biomedical Engineering at the University of Texas at Austin. He is the Principal Investigator of the Dynamic Medical Image and Computing Lab (DMIC Lab). His research focuses on medical image processing, functional imaging, and clinical applications related to biomedical engineering. Dr. Castillo's work involves advancing techniques in medical imaging to improve diagnostic and therapeutic outcomes, contributing to the field through innovative research and leadership in graduate education.

Research topics

• Medicine
• Internal medicine
• Anatomy
• Nuclear medicine
• Dentistry
• Virology
• Radiology
• Surgery

Selected publications

• Characterizing spatial differences between SPECT-ventilation and SPECT-perfusion in patients with lung cancer undergoing radiotherapy

  Radiotherapy and Oncology · 2021 · 12 citations

  • Medicine
  • Nuclear medicine
  • Radiology
  DOI

• Electric scooter craniofacial trauma

  Laryngoscope Investigative Otolaryngology · 2020 · 57 citations

  • Medicine
  • Surgery
  • Dentistry

  OBJECTIVE: The use of standing electronic scooters associated with micromobility applications (e-scooters) has risen nationally. The aim of this study was to obtain a detailed view of soft tissue and bony craniofacial injury associated with e-scooter-related trauma. METHODS: Single-institution retrospective case series of patients presenting to a level 1 trauma center emergency department or trauma unit with documented e-scooter-related craniofacial injury. RESULTS: Of 203 included patients, 188 (92.6%) patients sustained craniofacial injury. One hundred thirty-one (64.5%) had exclusively soft tissue injury, 3 (1.5%) exclusively bony injury, 51 (25.1%) both soft and bony injuries, and twenty-five (12.3%) patients sustained dental injury. Aesthetic units most frequently sustaining acute soft tissue injury were the forehead (n = 106, 34.6%), scalp (n = 36, 11.8%), chin (n = 34, 11.1%), upper lip (n = 32, 10.5%), and cheek (n = 31, 10.1%). Aesthetic subunits most often sustaining acute soft tissue injury included the brow (42, 13.7%), central forehead (39, 12.7%), lateral forehead (n = 25, 8.2%), and upper lip vermillion (n = 23, 7.5%). Craniofacial osseous fracture most often occurred in the orbit (n = 42, 24.6%) and maxilla (n = 40, 23.4%). Individual osseous segments most frequently sustaining acute fracture included the anterior maxillary sinus wall (n = 22, 12.9%), nasal bone (n = 20, 11.7%), lateral orbital wall (n = 16, 9.4%), orbital floor (n = 15, 8.8%), and zygomatic bone (13, 7.6%). CONCLUSIONS: Our analysis demonstrates that most patients presenting to our center with craniofacial trauma sustained acute bony fracture, most often to the midface. Our data of common injuries associated with e-scooter trauma could inform implementation in the form of facial safety equipment or safety skills training for e-scooter riders. LEVEL OF EVIDENCE: 4.

  DOI

• Association of anticoagulation dose and survival in hospitalized COVID‐19 patients: A retrospective propensity score‐weighted analysis

  European Journal Of Haematology · 2020 · 103 citations

  • Medicine
  • Internal medicine
  • Virology

  BACKGROUND: Hypercoagulability may contribute to COVID-19 pathogenicity. The role of anticoagulation (AC) at therapeutic (tAC) or prophylactic doses (pAC) is unclear. OBJECTIVES: We evaluated the impact on survival of different AC doses in COVID-19 patients. METHODS: Retrospective, multi-center cohort study of consecutive COVID-19 patients hospitalized between March 13 and May 5, 2020. RESULTS: A total of 3480 patients were included (mean age, 64.5 years [17.0]; 51.5% female; 52.1% black and 40.6% white). 18.5% (n = 642) required intensive care unit (ICU) stay. 60.9% received pAC (n = 2121), 28.7% received ≥3 days of tAC (n = 998), and 10.4% (n = 361) received no AC. Propensity score (PS) weighted Kaplan-Meier plot demonstrated different 25-day survival probability in the tAC and pAC groups (57.5% vs 50.7%). In a PS-weighted multivariate proportional hazards model, AC was associated with reduced risk of death at prophylactic (hazard ratio [HR] 0.35 [95% confidence interval {CI} 0.22-0.54]) and therapeutic doses (HR 0.14 [95% CI 0.05-0.23]) compared to no AC. Major bleeding occurred more frequently in tAC patients (81 [8.1%]) compared to no AC (20 [5.5%]) or pAC (46 [2.2%]) subjects. CONCLUSIONS: Higher doses of AC were associated with lower mortality in hospitalized COVID-19 patients. Prospective evaluation of efficacy and risk of AC in COVID-19 is warranted.

  DOI

Recent grants

• Development of a Novel Lung Function Imaging Modality for comprehensive management of lung cancer

  NIH · $2.4M · 2021–2026

Frequent coauthors

• Gary M. Vilke

  215 shared

• Thomas Guerrero

  University of California, San Diego

  177 shared

• Richard Castillo

  Emory University

  138 shared

• Theodore C. Chan

  University of California, San Diego

  133 shared

• Jesse J. Brennan

  University of California, San Diego

  93 shared

• J.P. Killeen

  University of California, San Diego

  81 shared

• Yevgeniy Vinogradskiy

  73 shared

• Leslie C. Oyama

  University of California, San Diego

  53 shared

Labs

• The Dynamic Medical Image and Computing LabPI

Education

• Postdoctoral Scholar and Lecturer, Mathematics

  University of California, Irvine

  2009

• Ph.D., Computational and Applied Mathematics

  Rice University

  2008

• M.A., Computational and Applied Mathematics

  Rice University

  2004

Awards & honors

• William J. Murray, Jr. Fellowship in Engineering

Similar researchers at University of Texas at Austin

• Carlos Caldash-218
• Thomas J. Hughesh-154
• George Georgiouh-107
• Keith Johnstonh-106
• Jeffrey Andrewsh-104