About

Eliyahu Stern is a Professor of Religious Studies and Jewish Studies at Yale University. He holds a Ph.D. from the University of California, Berkeley, and a B.A. from Yeshiva University. His academic focus is on Modern Jewish Intellectual and Cultural History. Stern has previously been a Junior William Golding Fellow in the Humanities at Brasenose College and the Oriental Institute, University of Oxford. He is the author of the award-winning book, The Genius: Elijah of Vilna and the Making of Modern Judaism, published by Yale University Press in 2012. His second monograph, Jewish Materialism: The Intellectual Revolution of the 1870s, also published by Yale University Press in 2018, explores the ideological background to Jews’ involvement in Zionism, Capitalism, and Communism. Stern teaches courses on topics such as The Global Right: From the French Revolution to the American Insurrection, Secularism: From the Enlightenment to the Present, Modern Jewish Intellectual History, and The Holocaust in Culture and Politics. He has served as a term member on the Council on Foreign Relations and as a consultant to the Museum of the History of Polish Jews in Warsaw, Poland. Currently, he is a member of the Academic Advisory Board of the Center of Jewish History.

Research topics

• Computer Science
• Engineering
• Biochemistry
• Medicine
• Chromatography
• Physics
• Business
• Chemistry
• Internal medicine
• Meteorology

Selected publications

• Editorial for ‘focus collection in memory of Prof Mark A Reed’

  Nanotechnology · 2023-12-27

  editorial
  PublisherDOI

• Macroprolactinemia Detection by Magnetically Assisted Polyethylene Glycol Precipitation: Potential for Automation

  The Journal of Applied Laboratory Medicine · 2020 · 2 citations

  • Computer Science
  • Computer Science
  • Chemistry

  BACKGROUND: Macroprolactin is an immunoglobulin-prolactin complex that is not bioactive in vivo but the prolactin component remains immunoreactive. The complex is a universal source of interference in prolactin immunoassays and commonly results in misdiagnosis of hyperprolactinemia with consequent clinical mismanagement of patients. Removal of macroprolactin by precipitation with polyethylene glycol (PEG) is an effective technique for identifying such patients but unfortunately not universally employed due to the manual nature of the procedure. METHODS: We developed a modified PEG precipitation technique using magnetic nanoparticles that we termed Magnetically Assisted PEG Precipitation (MAPP). This procedure was verified against an established PEG precipitation procedure. RESULTS: The MAPP procedure we developed was robust, reproducible, and affords the potential for automation of macroprolactin screening in clinical laboratories. Comparisons of prolactin levels obtained following MAPP in sera from patients with either true hyperprolactinemia or macroprolactinemia generated results comparable to that of conventional PEG precipitation. CONCLUSIONS: The MAPP technique yields results comparable to those of traditional PEG precipitation. Elimination of the need for centrifugation affords the possibility of automation and hence more widespread adoption of routine PEG screening by clinical laboratories.

  PublisherOA PDFDOI

• CMOS nanowire biosensing systems

  Cambridge University Press eBooks · 2015-02-28 · 1 citations

  book-chapter

  Lowering the costs of healthcare and increasing its accessibility is a critical need of today’s society. Miniaturized electronic sensors are a possible way to both improve healthcare and lower the cost of medical diagnostics. Their small size and portability can lead to integration into personalized diagnostics tools and emergency care. In addition, faster, smaller and more efficient sensors can greatly impact chemical and biological safety.

  PublisherDOI

• Calibration methods for silicon nanowire BioFETs

  2014-03-01 · 2 citations

  article

  Nanowire Field Effect Transistors have emerged as a promising technology for point-of-care application. However, their application as quantitative sensors has not been well explored. In this work we propose a calibration scheme for multiplexed nanoribbon field effect sensors by utilizing the initial current rate rather than the end point detection. A linear response of nanosensors is observed in medically relevant range of analyte concentration. Moreover, we are able to show that top-down fabrication technique yields reproducible result and devices with uniform electrical characteristics. In addition, we demonstrate that device calibration can be done by using either baseline current or device transconductance normalization.

  PublisherDOI

• Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice

  Journal of Clinical Investigation · 2013-03-01 · 118 citations

  articleOpen access

  The ability to selectively inactivate immune cells with immunosuppressants is a much sought-after modality for the treatment of systemic lupus erythematosus and autoimmunity in general. Here, we designed and tested a novel nanogel drug delivery vehicle for the immunosuppressant mycophenolic acid (MPA). Treatment with MPA-loaded nanogels increased the median survival time (MST) of lupus-prone NZB/W F1 mice by 3 months with prophylactic use (MST was 50 weeks versus 38 weeks without treatment), and by 2 months when administered after the development of severe renal damage (MST after proteinuria onset was 12.5 weeks versus 4 weeks without treatment). Equivalent and greater doses of MPA administered in buffer were not efficacious. Nanogels had enhanced biodistribution to organs and association with immune cells. CD4-targeted nanogels yielded similar therapeutic results compared with nontargeted formulations, with protection from glomerulonephritis and decreases in IFN-γ-positive CD4 T cells. DCs that internalized nanogels helped mediate immunosuppression, as they had reduced production of inflammatory cytokines such as IFN-γ and IL-12. Our results demonstrate efficacy of nanogel-based lupus therapy and implicate a mechanism by which immunosuppression is enhanced, in part, by the targeting of antigen-presenting cells.

  PublisherOA PDFDOI

• Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype

  Biomaterials · 2012-04-06 · 297 citations

  articleOpen access
  PublisherOA PDFDOI

• Chemoresistance to Valproate Treatment of Bovine Leukemia Virus-Infected Sheep; Identification of Improved HDAC Inhibitors

  Pathogens · 2012-10-08 · 9 citations

  articleOpen access

  We previously proved that a histone deacetylase inhibitor (valproate, VPA) decreases the number of leukemic cells in bovine leukemia virus (BLV)-infected sheep. Here, we characterize the mechanisms initiated upon interruption of treatment. We observed that VPA treatment is followed by a decrease of the B cell counts and proviral loads (copies per blood volume). However, all sheep eventually relapsed after different periods of time and became refractory to further VPA treatment. Sheep remained persistently infected with BLV. B lymphocytes isolated throughout treatment and relapse were responsive to VPA-induced apoptosis in cell culture. B cell proliferation is only marginally affected by VPA ex vivo. Interestingly, in four out of five sheep, ex vivo viral expression was nearly undetectable at the time of relapse. In two sheep, a new tumoral clone arose, most likely revealing a selection process exerted by VPA in vivo. We conclude that the interruption of VPA treatment leads to the resurgence of the leukemia in BLV-infected sheep and hypothesize that resistance to further treatment might be due to the failure of viral expression induction. The development of more potent HDAC inhibitors and/or the combination with other compounds can overcome chemoresistance. These observations in the BLV model may be important for therapies against the related Human T-lymphotropic virus type 1.

  PublisherOA PDFDOI

• Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy

  Nature Materials · 2012-07-13 · 488 citations

  articleOpen access
  PublisherOA PDFDOI

• 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as functional selective ligands at the hCB2 cannabinoid receptor

  Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) · 2012-01-01

  article

  Cannabinoid compounds (both synthetic and endogenous) exert their effects through at least two different G protein-coupled receptors, the CB1 and CB2 cannabinoid receptors. While the development of a large variety of ligands has permit to improve our knowledge on the pharmacological modulation of the CB1 receptor, the CB2 receptor is far less well-characterised. Particularly, in the context of ligand-selective activation of specific signalling pathways (functional selectivity) much less is described regarding CB2 than CB1 cannabinoid receptors. In a previous study, our group has reported on the development of a series of 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives showing high affinity and selectivity at CB2 receptor. We herein report on the functional characterisation of these ligands in [35S]-GTPγS assay which reveals that this original class of drugs contains agonists, antagonists and inverse agonists. Besides, the complexity of the CB2-mediated signalling pathways was further characterised using eight ligands selected amongst this series. The measurements of cAMP and MAPK phosphorylation levels demonstrated that several of these derivatives displayed preference for the regulation of distinct signalling cascades therefore supporting functional selectivity at CB2 cannabinoid receptor. Considering the growing interest for the CB2 cannabinoid receptor in the development of new drugs, the discovery and the functional characterisation of ligands displaying selective intracellular responses could provide valuable tools to extend the pharmacological comprehension of this receptor.

  Publisher

• Determination of Molecular Configuration by Debye Length Modulation

  Journal of the American Chemical Society · 2011-08-04 · 145 citations

  article

  Silicon nanowire field effect transistors (FETs) have emerged as ultrasensitive, label-free biodetectors that operate by sensing bound surface charge. However, the ionic strength of the environment (i.e., the Debye length of the solution) dictates the effective magnitude of the surface charge. Here, we show that control of the Debye length determines the spatial extent of sensed bound surface charge on the sensor. We apply this technique to different methods of antibody immobilization, demonstrating different effective distances of induced charge from the sensor surface.

  PublisherDOI

Frequent coauthors

• Mark A. Reed

  51 shared

• Tarek M. Fahmy

  Yale University

  45 shared

• Patrick Depreux

  Institut de Chimie

  28 shared

• Jean‐Pierre Hénichart

  Université de Lille

  24 shared

• Jean‐François Goossens

  Groupe de Recherche sur les formes Injectables et les Technologies Associées

  23 shared

• Régis Millet

  Lille Inflammation Research International Center

  23 shared

• Didier M. Lambert

  23 shared

• Daniel B. Turner‐Evans

  University of California, Santa Cruz

  21 shared

Awards & honors

• Junior William Golding Fellow in the Humanities at Brasenose…
• award-winning, The Genius: Elijah of Vilna and the Making of…