Dominik Wodarz

About

Dominik Wodarz obtained his undergraduate degree in Biology at Imperial College London and received a PhD in Zoology from the University of Oxford. He spent his postdoctoral years as a member of the Institute for Advanced Study in Princeton. Before joining the University of California San Diego (UCSD), he held faculty positions at the Fred Hutchinson Cancer Research Center in Seattle and the University of California Irvine. His professional biography highlights a strong background in biology and zoology, with significant postdoctoral experience at a prestigious research institute and faculty roles at notable research centers prior to his current position at UCSD.

Research topics

• Sociology
• Political Science
• Mathematics
• Demography
• Law
• Econometrics
• Economics
• Statistics
• Geography
• Biology

Selected publications

• Programming tumor evolution with selection gene drives to proactively combat drug resistance

  Nature Biotechnology · 2024-07-04 · 14 citations

  articleOpen access
  PublisherOA PDFDOI

• Mutant fixation in the presence of a natural enemy

  Nature Communications · 2023-10-20 · 5 citations

  articleOpen access1st authorCorresponding

  The literature about mutant invasion and fixation typically assumes populations to exist in isolation from their ecosystem. Yet, populations are part of ecological communities, and enemy-victim (e.g. predator-prey or pathogen-host) interactions are particularly common. We use spatially explicit, computational pathogen-host models (with wild-type and mutant hosts) to re-visit the established theory about mutant fixation, where the pathogen equally attacks both wild-type and mutant individuals. Mu…

  PublisherOA PDFDOI

• Human immunodeficiency virus dynamics in secondary lymphoid tissues and the evolution of cytotoxic T lymphocyte escape mutants

  Virus Evolution · 2024-01-01 · 4 citations

  articleOpen accessSenior author

  Abstract In secondary lymphoid tissues, human immunodeficiency virus (HIV) can replicate in both the follicular and extrafollicular compartments. Yet, virus is concentrated in the follicular compartment in the absence of antiretroviral therapy, in part due to the lack of cytotoxic T lymphocyte (CTL)–mediated activity there. CTLs home to the extrafollicular compartment, where they can suppress virus load to relatively low levels. We use mathematical models to show that this compartmentalization c…

  PublisherOA PDFDOI

• Dynamically adjusted cell fate decisions and resilience to mutant invasion during steady-state hematopoiesis revealed by an experimentally parameterized mathematical model

  Proceedings of the National Academy of Sciences · 2024-09-09 · 4 citations

  articleOpen accessSenior authorCorresponding

  A major next step in hematopoietic stem cell (HSC) biology is to enhance our quantitative understanding of cellular and evolutionary dynamics involved in undisturbed hematopoiesis. Mathematical models have been and continue to be key in this respect, and are most powerful when parameterized experimentally and containing sufficient biological complexity. In this paper, we use data from label propagation experiments in mice to parameterize a mathematical model of hematopoiesis that includes homeos…

  PublisherOA PDFDOI

• Author Correction: Barcoded HIV-1 reveals viral persistence driven by clonal proliferation and distinct epigenetic patterns

  Nature Communications · 2025-10-27 · 1 citations

  articleOpen access
  PublisherOA PDFDOI

Recent grants

• NIH Grant R01AI058153

  NIH · $530k · 2011

• NIH Grant R01AI093998

  NIH · $1.1M · 2016

• Hybrid Deterministic-Stochastic Methodology for Simulating Spatial Evolution in Large Populations

  NSF · $400k · 2018–2022

Frequent coauthors

• Natalia L. Komarova

  202 shared

• Ignacio A. Rodriguez-Brenes

  32 shared

• Ajay Goel

  29 shared

• David N. Levy

  24 shared

• Jesse Kreger

  University of Southern California

  24 shared

• Martin A. Nowak

  Harvard University

  24 shared

• Luis M. Schang

  Cornell University

  23 shared

• Paul Klenerman

  John Radcliffe Hospital

  20 shared

Labs

• Wodarz LabPI

Similar researchers at University of California, San Diego

• Elsa Clelandh-70
• Jonathan Shurinh-59
• Kaustuv Royh-54