Dennis M Abraham

About

Dennis M Abraham is an Assistant Professor of Medicine in the Department of Medicine at Duke University. His professional contact email is dennis.abraham@duke.edu. The department is part of Duke University and Duke University Health System, located in Durham, North Carolina. Specific details about his research focus, background, or key contributions are not provided on the page.

Research topics

• Cell biology
• Biology
• Biochemistry
• Internal medicine
• Medicine
• Pharmacology
• Endocrinology
• Pathology
• Neuroscience

Selected publications

• β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors

  Cell · 2020 · 148 citations

  PublisherOA PDFDOI

• Sirtuin 5 is required for mouse survival in response to cardiac pressure overload

  Journal of Biological Chemistry · 2017-10-03 · 110 citations

  articleOpen access

  /NADH. Together, these abnormalities suggest that SIRT5 deacylates protein substrates involved in cellular oxidative metabolism to maintain mitochondrial energy production. Overall, the functional and metabolic results presented here suggest an accelerated development of cardiac dysfunction in SIRT5KO mice in response to TAC, explaining increased mortality upon cardiac stress. Our findings reveal a key role for SIRT5 in maintaining cardiac oxidative metabolism under pressure overload to ensure s…

  PublisherOA PDFDOI

• Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure

  Circulation Research · 2020 · 78 citations

  RATIONALE: Circumstantial evidence links the development of heart failure to posttranslational modifications of mitochondrial proteins, including lysine acetylation (Kac). Nonetheless, direct evidence that Kac compromises mitochondrial performance remains sparse. OBJECTIVE: This study sought to explore the premise that mitochondrial Kac contributes to heart failure by disrupting oxidative metabolism. METHODS AND RESULTS: A DKO (dual knockout) mouse line with deficiencies in CrAT (carnitine acety…

  PublisherOA PDFDOI

• Pulmonary Hypertension Subtypes and Mortality in CKD

  American Journal of Kidney Diseases · 2019-11-12 · 66 citations

  articleOpen access
  PublisherOA PDFDOI

• Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload

  Journal of Biological Chemistry · 2018-05-16 · 49 citations

  articleOpen access

  Mitochondrial Sirtuin 5 (SIRT5) is an NAD+-dependent demalonylase, desuccinylase, and deglutarylase that controls several metabolic pathways. A number of recent studies point to SIRT5 desuccinylase activity being important in maintaining cardiac function and metabolism under stress. Previously, we described a phenotype of increased mortality in whole-body SIRT5KO mice exposed to chronic pressure overload compared with their littermate WT controls. To determine whether the survival phenotype we r…

  PublisherOA PDFDOI

Recent grants

• TREK-1 in fibroblast differentiation and cardiac fibrosis development

  NIH · $128k · 2015–2020

• TREK-1 in fibroblast differentiation and cardiac fibrosis development

  NIH · $618k · 2015–2020

Frequent coauthors

• Daichi Shimbo

  Columbia University Irving Medical Center

  53 shared

• Howard A. Rockman

  Duke Medical Center

  53 shared

• Matthew M. Burg

  VA Connecticut Healthcare System

  52 shared

• William F. Chaplin

  St. John's University

  41 shared

• Lauren Taggart Wasson

  36 shared

• Sujith Kuruvilla

  University of Virginia

  36 shared

• Lan Mao

  Duke University

  35 shared

• William Gerin

  Pennsylvania State University

  21 shared

Similar researchers at Duke University

• Seungkirl Ahnh-83
• S. Munir Alamh-77
• Paul F. Agrish-54