David R Gagnon
· MD, PhD Research ProfessorBoston University · Biostatistics
Active 1979–2026
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About
David R Gagnon, MD, PhD, is a Research Professor of Biostatistics at Boston University School of Public Health. He serves as the director of biostatistics in the division of Population Health and Data Science at the Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC) located at the Boston VA hospital. Dr. Gagnon is also a biostatistician with the Million Veteran Program and the 'All of Us' Precision Medicine Initiative. His research interests include phenomics, pharmacoepidemiology, longitudinal data analysis, survival analysis, and statistical computing. He teaches courses such as Categorical Data Analysis, Advanced Methods in Statistical Computing, and Applications of Statistical Methods in Clinical Research.
Research topics
- Medicine
- Computer Science
- Pharmacology
- Computational biology
- Biology
- Bioinformatics
- Genetics
Selected publications
Comparative Effectiveness of BNT162b2 and mRNA-1273 Vaccines in U.S. Veterans
New England Journal of Medicine · 2021 · 268 citations
BACKGROUND: The messenger RNA (mRNA)-based vaccines BNT162b2 and mRNA-1273 are more than 90% effective against coronavirus disease 2019 (Covid-19). However, their comparative effectiveness for a range of outcomes across diverse populations is unknown. METHODS: We emulated a target trial using the electronic health records of U.S. veterans who received a first dose of the BNT162b2 or mRNA-1273 vaccine between January 4 and May 14, 2021, during a period marked by predominance of the SARS-CoV-2 B.1…
Nature Medicine · 2021 · 245 citations
JAMA Network Open · 2024-12-06 · 14 citations
articleOpen accessImportance: The American Heart Association proposed Life's Essential 8 (LE8) as an enhanced measurement tool for cardiovascular health. Objective: To examine the association of LE8 with risk of atherosclerotic cardiovascular disease (ASCVD) incidence and prognosis in veterans. Design, Setting, and Participants: This was a prospective cohort study of US veterans enrolled in the Department of Veterans Affairs (VA) Million Veteran Program (MVP) between 2011 and 2022. Data were analyzed from 2023 to…
Nature Genetics · 2025-10-31 · 4 citations
articleOpen accessThe high burden of dilated cardiomyopathy (DCM) in individuals of African descent remains incompletely explained. Here, to explore a genetic basis, we conducted a genome-wide association study in 1,802 DCM cases and 93,804 controls of African genetic ancestry (AFR). A nonsense variant ( rs3211938 :G) in CD36 was associated with increased risk of DCM. This variant, believed to be under positive selection due to a protective role in malaria resistance, is present in 17% of AFR individuals but <0.1…
Journal of the American Medical Informatics Association · 2024-12-13 · 3 citations
articleOpen accessOBJECTIVE: Event capture in clinical trials is resource-intensive, and electronic medical records (EMRs) offer a potential solution. This study develops algorithms for EMR-based death and hospitalization capture and compares them with traditional event capture methods. MATERIALS AND METHODS: We compared the effectiveness of EMR-based event capture and site-captured events adjudicated by a clinical endpoint committee in the multi-center INfluenza Vaccine to Effectively Stop cardio Thoracic Events…
Frequent coauthors
- 564 shared
Kelly Cho
VA Boston Healthcare System
- 383 shared
Peter W.F. Wilson
Emory Clinic
- 318 shared
J. Michael Gaziano
Harvard University
- 238 shared
Luc Djoussé
Brigham and Women's Hospital
- 236 shared
Yuk‐Lam Ho
VA Boston Healthcare System
- 151 shared
Ariela R. Orkaby
Geriatric Research Education and Clinical Center
- 138 shared
Ashley Galloway
VA Boston Healthcare System
- 135 shared
L. Adrienne Cupples
Boston University
Labs
Education
- 1998
PhD in Biostatistics, Graduate School of Arts and Sciences
Boston University
- 1989
MPH, School of Public Health, Biostatistics and Epidemiology
Boston University
- 1986
MD
Tufts University School of Medicine
- 1981
BA, Biology
Saint Anselm College
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