David Knazovicky

About

David Knazovicky is an Assistant Professor of Small Animal Orthopedics at NC State University’s College of Veterinary Medicine. He began his career at NC State in 2013 as a Research Assistant in the Comparative Pain Research Laboratory and has since advanced through a Small Animal Rotating Internship, a Small Animal Surgery residency, and a role as a Clinical Veterinarian in Orthopedics and Rehabilitation. His foundational training includes a Doctor of Veterinary Medicine and a PhD from the University of Veterinary Medicine in Košice, Slovakia. With over a decade of clinical, research, and teaching engagement at NC State, his work is dedicated to advancing small animal orthopedics and improving patient outcomes through evidence-based practice. His clinical focus centers on small animal orthopedic diseases, with a secondary specialty in joint replacement surgery. He serves as a senior clinician on the Small Animal Orthopedics Service, providing supervision, clinical instruction, and case management for veterinary students and surgical house officers. He performs the majority of Total Hip Replacements at NC State and is completing a Fellowship in Joint Replacement Surgery. His expertise includes total hip replacement surgery, cranial cruciate ligament disease, management of complex orthopedic and musculoskeletal conditions, and management of complex fractures and ligament injuries.

Research topics

• Medicine
• Psychology
• Neuroscience
• Audiology
• Cognitive psychology
• Immunology
• Oncology
• Pathology
• Internal medicine

Selected publications

• A canine-specific anti-nerve growth factor antibody alleviates pain and improves mobility and function in dogs with degenerative joint disease-associated pain

  BMC Veterinary Research · 2015-04-29 · 96 citations

  articleOpen access

  BACKGROUND: There is a critical need for proven drugs other than non-steroidal anti-inflammatory drugs for treatment of degenerative joint disease (DJD) pain in dogs. Antibodies against nerve growth factor (NGF) are analgesic in rodent models and in humans with DJD. This pilot study aimed to evaluate the efficacy of a novel caninised anti-NGF antibody (NV-01) for the treatment of DJD pain in dogs. In a randomized, parallel group, stratified, double masked, placebo controlled, proof of principle…

  PublisherOA PDFDOI

• Widespread somatosensory sensitivity in naturally occurring canine model of osteoarthritis

  Pain · 2016-02-20 · 82 citations

  articleOpen access1st authorCorresponding

  Osteoarthritis (OA)-associated pain is a leading cause of disability. Central sensitization (CS), as a result of OA, is recognized as an important facet of human patients' chronic pain and has been measured in people using quantitative sensory testing (QST) testing. The spontaneous canine OA model has been suggested as a good translational model, but CS has not been explored in this model. In this study, QST was performed on dogs with and without spontaneous hip or stifle OA to determine whether…

  PublisherDOI

• Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain

  PeerJ · 2015-02-17 · 53 citations

  articleOpen access1st authorCorresponding

  Chronic pain due to osteoarthritis (OA) can lead to significant disruption of sleep and increased restlessness. Our objective was to assess whether naturally occurring canine OA is associated with nighttime restlessness and so has potential as a model of OA-associated sleep disturbance. The study was designed as a two-part prospective masked, placebo-controlled study using client-owned dogs (Part A n = 60; Part B n = 19). Inclusion criteria consisted of OA-associated joint pain and mobility impa…

  PublisherDOI

• Mechanical and Thermal Sensory Testing in Normal Chondrodystrophoid Dogs and Dogs with Spinal Cord Injury caused by Thoracolumbar Intervertebral Disc Herniations

  Journal of Veterinary Internal Medicine · 2016-03-01 · 25 citations

  articleOpen access

  BACKGROUND: Intervertebral disc herniation is a common cause of spinal cord injury (SCI) causing paralysis and sensory loss. Little quantitative information is available on the loss and recovery of sensation in dogs with SCI. OBJECTIVES: To determine whether quantitative sensory testing (QST) can be used to establish thermal and mechanical sensory thresholds in chrondrodystrophoid dogs and compare thresholds among normal dogs and dogs with different grades of SCI. ANIMALS: Thirty-three client-ow…

  PublisherDOI

• Replicate effects and test–retest reliability of quantitative sensory threshold testing in dogs with and without chronic pain

  Veterinary Anaesthesia and Analgesia · 2017-01-10 · 23 citations

  article1st authorCorresponding
  PublisherDOI

Frequent coauthors

• B. Duncan X. Lascelles

  North Carolina State University

  39 shared

• Beth Case

  MedStar Washington Hospital Center

  28 shared

• Margaret E. Gruen

  North Carolina State University

  21 shared

• William Maixner

  DaVita Clinical Research (United States)

  20 shared

• Erika S. Helgeson

  University of Minnesota

  19 shared

• Mila Freire

  Instituto de Instrumentación para Imagen Molecular

  9 shared

• Andrea Thomson

  North Carolina State University

  6 shared

• Valent Ledecký

  University of Veterinary Medicine in Košice

  5 shared

Labs

• Small Animal OrthopedicsPI

Education

• Ph.D., Comparative Medicine

  North Carolina State University

  2004

• M.S., Comparative Medicine

  University of California, Davis

  1999

• B.S., Animal Science

  University of California, Davis

  1997

Similar researchers at North Carolina State University

• Edward Breitschwerdth-100
• Craig Harmsh-54