David Eliezer

About

David Eliezer, Ph.D., is a Professor of Biochemistry and Biophysics at Weill Cornell Medicine. His research primarily involves the application of NMR spectroscopy to problems in non-native structural biology, with a focus on characterizing the location, extent of structure, and intermolecular interactions of aggregation-competent partially unfolded states of proteins involved in neurodegenerative diseases. His specific targets include proteins related to Alzheimer's Disease and Parkinson's Disease. The Eliezer laboratory aims to better understand α-synuclein, a neuronal protein associated with Parkinson’s disease, in both healthy and diseased brains by studying its membrane-bound and aggregated states. His work contributes to the understanding of protein misfolding and aggregation processes relevant to neurodegenerative conditions.

Research topics

• Internal medicine
• Anatomy
• Medicine
• Neuroscience
• Biology

Selected publications

• Tau induces PSD95–neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration

  Nature Neuroscience · 2020 · 124 citations

  DOI

• Phosphoglycerate kinase is a central leverage point in Parkinson’s disease–driven neuronal metabolic deficits

  Science Advances · 2024-08-21 · 29 citations

  articleOpen access

  Although certain drivers of familial Parkinson's disease (PD) compromise mitochondrial integrity, whether metabolic deficits underly other idiopathic or genetic origins of PD is unclear. Here, we demonstrate that phosphoglycerate kinase 1 (PGK1), a gene in the PARK12 susceptibility locus, is rate limiting in neuronal glycolysis and that modestly increasing PGK1 expression boosts neuronal adenosine 5'-triphosphate production kinetics that is sufficient to suppress PARK20-driven synaptic dysfuncti…

  PublisherDOI

• Alpha synuclein modulates mitochondrial Ca2+ uptake from ER during cell stimulation and under stress conditions

  npj Parkinson s Disease · 2023-09-23 · 26 citations

  articleOpen accessCorresponding

  Abstract Alpha synuclein (a-syn) is an intrinsically disordered protein prevalent in neurons, and aggregated forms are associated with synucleinopathies including Parkinson’s disease (PD). Despite the biomedical importance and extensive studies, the physiological role of a-syn and its participation in etiology of PD remain uncertain. We showed previously in model RBL cells that a-syn colocalizes with mitochondrial membranes, depending on formation of N-terminal helices and increasing with mitoch…

  PublisherOA PDFDOI

• Carbon dots as dual inhibitors of tau and amyloid-beta aggregation for the treatment of Alzheimer's disease

  Acta Biomaterialia · 2024-06-05 · 23 citations

  articleOpen access
  PublisherOA PDFDOI

• Control of G protein–coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains

  Proceedings of the National Academy of Sciences · 2024-07-10 · 11 citations

  articleOpen accessSenior authorCorresponding

  G protein-coupled receptors (GPCRs) control intracellular signaling cascades via agonist-dependent coupling to intracellular transducers including heterotrimeric G proteins, GPCR kinases (GRKs), and arrestins. In addition to their critical interactions with the transmembrane core of active GPCRs, all three classes of transducers have also been reported to interact with receptor C-terminal domains (CTDs). An underexplored aspect of GPCR CTDs is their possible role as lipid sensors given their pro…

  PublisherOA PDFDOI

Recent grants

• NIH Grant F32GM017098

  NIH · $75k

• NIH Grant R01AG019391

  NIH · $2.6M · 2010

• NIH Grant R01AG025440

  NIH · $1.2M · 2010

Frequent coauthors

• Vladimir N. Uversky

  40 shared

• Sebastian Doniach

  Stanford University

  40 shared

• Keith O. Hodgson

  Stanford Synchrotron Radiation Lightsource

  39 shared

• Anthony L. Fink

  36 shared

• Daniel J. Segel

  Stanford University

  36 shared

• Tapojyoti Das

  St. Jude Children's Research Hospital

  35 shared

• Trudy F. Ramlall

  Regeneron (United States)

  34 shared

• Diana Acosta

  32 shared

Similar researchers at Cornell University

• Frederick R. Maxfieldh-108
• Timothy McGrawh-65
• Anant Menonh-60