David Cash

· Professor of Computer Science

University of Chicago · Computer Science

Active 1989–2026

h-index75

Citations26.4k

Papers930507 last 5y

Funding$1.1M

Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.

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About

David Cash is a Professor of Computer Science at the University of Chicago. The page does not provide specific details about his research focus, background, or key contributions.

Research topics

Internal medicine
Oncology
Medicine
Psychology
Genetics
Biology
Pathology
Nuclear medicine
Bioinformatics
Psychiatry

Selected publications

Anatomical progression of genetic frontotemporal lobar degeneration across the lifespan
Brain · 2025-05-25 · 4 citations
articleOpen access
The recent development of brain charts for the human lifespan offers an ideal modelling framework for pathologies such as genetic frontotemporal lobar degeneration (FTLD) which likely involve both neurodevelopmental and neurodegenerative processes over a lifetime. We have therefore combined this new methodological approach with MRI data from asymptomatic and symptomatic subjects, carrying C9orf72, MAPT or GRN mutations from the Genetic FTD Initiative (GENFI) and the ARTFL-LEFFTDS Longitudinal Fr…
Publisher OA PDF DOI
Cerebrovascular Reactivity at Rest and Its Association With Cognitive Function in People With Genetic Frontotemporal Dementia
Neurology · 2025-09-04 · 1 citations
articleOpen access
BACKGROUND AND OBJECTIVES: Cerebrovascular reactivity (CVR) is an indicator of cerebrovascular health, and its signature in familial frontotemporal dementia (FTD) remains unknown. The primary aim was to investigate CVR in genetic FTD using an fMRI index of vascular contractility termed resting-state fluctuation amplitudes (RSFAs) and to assess whether RSFA differences are moderated by age. A secondary aim was to study the relationship between RSFA and cognition. METHODS: < 0.05. RESULTS: = 0.008…
Publisher OA PDF DOI
Assessing the clinical relevance of amyloid PET prediction from T1w MRI for Alzheimer’s disease
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition · 2025-09-16
article
Motivation: Amyloid PET imaging is important for Alzheimer's disease (AD) diagnosis but currently largely inaccessible. As an alternative, generating synthetic PET data from T1w MRI has been explored. However, current PET synthesis models lack rigorous evaluation in brain regions that are clinically relevant to AD pathology. Goal(s): To provide a clinically focused evaluation of T1w-to-amyloid PET synthesis models for AD. Approach: We will train a generative model to predict PET from T1w MRI and…
Publisher DOI
Location patterns of WMH in a multi-cohort study — generalisability and evaluation
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition · 2025-09-16
article
Motivation: The location distribution of white matter hyperintensities (WMH) may reflect different pathological processes but consistent characterisation across cohorts is challenging. Goal(s): To develop and validate a framework for identifying WMH distribution patterns across multiple cohorts. Approach: We employed unsupervised clustering to analyse WMH distribution in over 31,000 participants from ADNI3, Insight46, SABRE and UK Biobank, assessed its reproducibility, clinical relevance and pre…
Publisher DOI
Cellular signatures underlying functional resilience in presymptomatic frontotemporal dementia
Brain · 2025-11-21
articleOpen access
Frontotemporal dementia (FTD) shows autosomal dominant transmission in up to a third of families, enabling the study of presymptomatic and prodromal phases. Despite self-reported well-being and normal daily cognitive functioning, brain structural changes are evident a decade or more before the expected onset of disease. This divergence between cognitive function and brain structure contrasts with the coupling of structural and functional decline after symptom onset. In healthy ageing, it has bee…
Publisher DOI

Recent grants

CAREER: Cryptography for Secure Outsourcing
NSF · $447k · 2015–2019
CAREER: Cryptography for Secure Outsourcing
NSF · $287k · 2018–2021
SaTC: CORE: Medium: Collaborative: Cryptographic Data Protection in Modern Systems
NSF · $366k · 2018–2022

Frequent coauthors

Nick C. Fox
National Hospital for Neurology and Neurosurgery
1252 shared
Ian B. Malone
855 shared
Martina Bocchetta
University College London
690 shared
Jonathan M. Schott
UK Dementia Research Institute
668 shared
David L. Thomas
University College London
659 shared
Jonathan D. Rohrer
UK Dementia Research Institute
643 shared
Carole H. Sudre
University College London
547 shared
Sébastien Ourselin
544 shared

Labs

Research Labs & GroupsPI

Education

Ph.D., Computer Science
University of Chicago
2005
M.S., Computer Science
University of Chicago
2002
B.S., Computer Science
University of Illinois at Urbana-Champaign
1999

Awards & honors

2025 Quantrell Award for Undergraduate Teaching
2019 Keynote Speaker, NSS
2015 CAREER Award Research Fellow at Simons Institute
2011 Best Paper, Eurocrypt
2010 Best Paper, Eurocrypt

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