David Alfred Hoffman

About

David Alfred Hoffman is the Steed Family Professor of the Practice of Public Policy and a Professor of the Practice in the Sanford School of Public Policy at Duke University. He serves as the Interim Director of the Duke Initiative for Science & Society and is an Associate of the Duke Initiative for Science & Society. Additionally, he is an Affiliate Faculty Member at the Duke-Margolis Institute for Health Policy. His work includes creating a three-part podcast series titled 'Defending Democracy (and Us!) From Big Tech,' which reflects his engagement with contemporary issues at the intersection of technology, democracy, and policy. His contact information is provided as david.hoffman@duke.edu, and he is based in the Sanford Building in Durham, North Carolina.

Research topics

• Chemistry
• Stereochemistry
• Chromatography
• Physics
• Materials science
• Nuclear physics
• Organic chemistry
• Nuclear magnetic resonance
• Computational chemistry
• Environmental chemistry

Selected publications

• The Missing Linker: A Dimerization Motif Located within Polyketide Synthase Modules

  ACS Chemical Biology · 2013-03-14 · 44 citations

  articleOpen access

  The dimerization of multimodular polyketide synthases is essential for their function. Motifs that supplement the contacts made by dimeric polyketide synthase enzymes have previously been characterized outside the boundaries of modules, at the N- and C-terminal ends of polyketide synthase subunits. Here we describe a heretofore uncharacterized dimerization motif located within modules. The dimeric state of this dimerization element was elucidated through the 2.6 Å resolution crystal structure of…

  PublisherOA PDFDOI

• Absolute Carbon Stable Isotope Ratio in the Vienna Peedee Belemnite Isotope Reference Determined by ¹H NMR Spectroscopy

  Analytical Chemistry · 2022 · 43 citations

  1st authorCorresponding

  C. Results provide a new and independent measure of the carbon isotope composition of VPDB, improving our understanding of this important isotope reference.

  PublisherOA PDFDOI

• A Pseudocatenane Structure Formed between DNA and A Cyclic Bisintercalator

  Journal of the American Chemical Society · 2009-02-23 · 29 citations

  articleOpen access

  Targeting double-stranded DNA with small molecules remains an active area of basic research. Herein is described a cyclic DNA bisintercalator that is based on two naphthalene diimide (NDI) intercalating units tethered by one linking element specific for binding in the minor groove and the other linking element specific for binding in the major groove. DNase I footprinting revealed a strong preference for binding the sequence 5'-GGTACC-3'. NMR structural studies of the complex with d(CGGTACCG)(2)…

  PublisherOA PDFDOI

• The Crystal Structure of Spermidine/Spermine <i>N</i>¹-Acetyltransferase in Complex with Spermine Provides Insights into Substrate Binding and Catalysis^,

  Biochemistry · 2008-08-09 · 28 citations

  articleSenior author

  The enzyme spermidine/spermine N (1)-acetyltransferase (SSAT) catalyzes the transfer of acetyl groups from acetylcoenzyme A to spermidine and spermine, as part of a polyamine degradation pathway. This work describes the crystal structure of SSAT in complex with coenzyme A, with and without bound spermine. The complex with spermine provides a direct view of substrate binding by an SSAT and demonstrates structural plasticity near the active site of the enzyme. Associated water molecules bridge sev…

  PublisherDOI

• Position-Specific Carbon Stable Isotope Ratios by Proton NMR Spectroscopy

  Analytical Chemistry · 2019-11-07 · 23 citations

  article1st authorCorresponding

  Carbon stable isotopes provide insights into the origin and synthesis pathway of an organic molecule, and hence, contribute information that is fundamental to understanding chemical, physiological, and ecological processes. Organic carbon 13C/12C isotope ratios are commonly obtained as whole-molecule averages or as measurements of bulk samples. In contrast, position-specific isotope analysis (PSIA) provides isotope ratios for the individual carbons within a molecule, providing additional informa…

  PublisherDOI

Recent grants

• NIH Grant R01AI040187

  NIH · $2.4M · 2008

• NIH Grant K02AI001497

  NIH · $443k · 2003

Frequent coauthors

• Stephen W. White

  St. Jude Children's Research Hospital

  50 shared

• V. Ramakrishnan

  MRC Laboratory of Molecular Biology

  32 shared

• Christopher Stan Cameron

  Sanford Health

  26 shared

• Christopher Davies

  25 shared

• Peter Schmid

  19 shared

• Paul Shapshak

  Tampa General Hospital

  18 shared

• Maryam Darvish

  Arak University of Medical Sciences

  18 shared

• S. Nakamura

  University of Tsukuba

  17 shared

Similar researchers at University of Texas at Austin

• Kenneth A. Dodgeh-165
• Sebastian S. Jamesh-78
• Marc A. Jeulandh-51