Daniel Goldfarb

Epidemiology of Kidney Stones

Healthcare · 2023 · 258 citations

In the past two decades, major breakthroughs that improve our understanding of the pathophysiology and therapy of kidney stones (KS) have been lacking. The disease continues to be challenging for patients, physicians, and healthcare systems alike. In this context, epidemiological studies are striving to elucidate the worldwide changes in the patterns and the burden of the disease and identify modifiable risk factors that contribute to the development of kidney stones. Our expanding knowledge of…

Impending Shortages of Kidney Replacement Therapy for COVID-19 Patients

Clinical Journal of the American Society of Nephrology · 2020 · 120 citations

Practicing nephrology in New York City, at the epicenter of the novel coronavirus disease 2019 (COVID-19) pandemic in the United States, we have been struck by the continued focus on the concern that a critical deficiency of ventilators will occur. Our efforts in the past weeks have led us to fear that another critical shortage may occur before that of ventilators: our ability to deliver KRT for patients severely affected by COVID-19. We and other centers in New York are encountering significant…

Extracorporeal treatment for poisoning to beta-adrenergic antagonists: systematic review and recommendations from the EXTRIP workgroup

Critical Care · 2021 · 47 citations

Abstract Background β-adrenergic antagonists (BAAs) are used to treat cardiovascular disease such as ischemic heart disease, congestive heart failure, dysrhythmias, and hypertension. Poisoning from BAAs can lead to severe morbidity and mortality. We aimed to determine the utility of extracorporeal treatments (ECTRs) in BAAs poisoning. Methods We conducted systematic reviews of the literature, screened studies, extracted data, and summarized findings following published EXTRIP methods. Results A…

Physiology and immunology of a pig-to-human decedent kidney xenotransplant

Nature · 2025-11-13 · 16 citations

Genetic and Clinical Characterization of a Large Cohort with Suspected Monogenic Stone Disease

Clinical Journal of the American Society of Nephrology · 2025-08-12 · 5 citations

Key Points Genetic testing of individuals suspected of monogenic urinary stone disease resolved 34% of families with 22 different genes detected. Resolved individuals had a lower baseline and last visit eGFR and earlier age of stone presentation than the unresolved group. Specific phenotypes and younger diagnostic age were associated with a monogenic cause, allowing refinement of future screenings. Background Urinary stone disease with a clear genetic cause, monogenic stone disease (MSD), is inc…