Dane Parker

About

Welcome to the laboratory of Dane Parker at Rutgers New Jersey Medical School. We are interested in studying host-pathogen interactions.

Research topics

• Medicine
• Microbiology
• Immunology
• Biology

Selected publications

• Clinical Impact of Staphylococcus aureus Skin and Soft Tissue Infections

  Antibiotics · 2023 · 236 citations

  Senior authorCorresponding

  infection, and potential for antibiotic resistance.

  DOI

• Characterization of the Anti-Inflammatory Capacity of IL-10-Producing Neutrophils in Response to Streptococcus pneumoniae Infection

  Frontiers in Immunology · 2021 · 46 citations

  limits lung injury and is important to mediate an effective immune response required for host survival.

  DOI

• The <i>Staphylococcus aureus</i> non-coding RNA IsrR regulates TCA cycle activity and virulence

  Nucleic Acids Research · 2024-12-19 · 11 citations

  articleOpen access

  Staphylococcus aureus has evolved mechanisms to cope with low iron (Fe) availability in host tissues. Staphylococcus aureus uses the ferric uptake transcriptional regulator (Fur) to sense titers of cytosolic Fe. Upon Fe depletion, apo-Fur relieves transcriptional repression of genes utilized for Fe uptake. We demonstrate that an S. aureus Δfur mutant has decreased expression of acnA, which codes for the Fe-dependent enzyme aconitase. This prevents the Δfur mutant from growing with amino acids as…

  PublisherOA PDFDOI

• Trained immunity in the lung

  eLife · 2025-08-01 · 8 citations

  reviewOpen accessSenior author

  Trained immunity represents a recent concept that elucidates the long-term reprogramming of innate immune cells, enabling them to adapt and respond more effectively to subsequent encounters with diverse pathogens. Initially recognized through the Bacillus Calmette–Guérin vaccine, Candida albicans infection, and β-glucan administration, this phenomenon challenges the traditional view that immune memory is exclusive to the adaptive immune system. Trained immunity is characterized by epigenetic and…

  PublisherDOI

• Monocyte-regulated interleukin 12 production drives clearance of Staphylococcus aureus

  PLoS Pathogens · 2024-10-17 · 8 citations

  articleOpen accessSenior authorCorresponding

  Staphylococcus aureus is a versatile bacterium responsible for conditions ranging from mild skin and soft-tissue infections to serious disorders such as pneumonia and sepsis. Monocytes play a role in protection against pathogens by migrating to inflamed tissues and differentiating into macrophages but their specific role in the context of S. aureus pulmonary infection has not been fully elucidated. Using a CCR2-DTR transgenic mouse model we demonstrate that over the course of infection monocyte…

  PublisherDOI

Recent grants

• NIH Grant R56HL125653

  NIH · $384k · 2017

• Role of type III interferons in Staphylococcus aureus respiratory tract infection

  NIH · $1.8M · 2018–2022

• Humanized lung implant mouse model to study Staphylococcus aureus airway interactions

  NIH · $430k · 2020–2024

Frequent coauthors

• Paul J. Planet

  Children's Hospital of Philadelphia

  38 shared

• Alice Prince

  Columbia University

  34 shared

• Ji‐Sun Kim

  Korea Research Institute of Bioscience and Biotechnology

  30 shared

• Ruth M. Kennan

  Monash University

  29 shared

• Julian I. Rood

  Monash University

  29 shared

• Sílvia Pires

  Cornell University

  25 shared

• Alejandro Pironti

  New York University

  24 shared

• Gregory Putzel

  Cornell University

  24 shared

Labs

• Parker LaboratoryPI

Similar researchers at Rutgers University

• Saul Susterh-89
• Liping Lih-38
• Sukhwinder Singhh-34