Dana C Dolinoy

About

Dana C Dolinoy, PhD, MSc, is the NSF International Chair of Environmental Health Sciences and a Professor at the University of Michigan School of Public Health, specializing in environmental health sciences and nutritional sciences. Her research has a broad focus on genomics and toxicology, with specific interest in epigenetic research, including environmental epigenomics and the developmental origins of health and disease. She integrates the work of toxicologists, epidemiologists, and bioinformaticians to characterize the effects of environmental factors on the epigenome and develops precision environmental epigenomics tools for toxicological research and therapeutic applications, particularly related to metabolic syndrome, neurodevelopmental disorders, and cancer. Dr. Dolinoy serves as the Director of the University of Michigan NIEHS P30 Core Center, 'Lifestage Environmental Exposures and Diseases' (M-LEEaD), and as Faculty Director of the Michigan Medical Center's Epigenomics Core. Her commitment to environmental and nutritional epigenomics research emphasizes the impact of environmental insults during sensitive life stages that influence adult disease risk. Her research projects include advancing understanding of perinatal exposures on the epigenome and health risks, utilizing human and mouse models, and longitudinal birth cohort samples. She is also a member of the NIEHS TaRGET II Consortia and MPI of a project investigating the effects of preconception weight loss on…

Research topics

• Biology
• Genetics
• Medicine
• Physiology
• Internal medicine
• Endocrinology
• Chemistry
• Immunology
• Computer Science
• Ecology

Selected publications

• A precision environmental health approach to prevention of human disease

  Nature Communications · 2023 · 106 citations

  Human health is determined by the interaction of our environment with the genome, epigenome, and microbiome, which shape the transcriptomic, proteomic, and metabolomic landscape of cells and tissues. Precision environmental health is an emerging field leveraging environmental and system-level ('omic) data to understand underlying environmental causes of disease, identify biomarkers of exposure and response, and develop new prevention and intervention strategies. In this article we provide real-l…

  DOI

• Maternal lipid levels across pregnancy impact the umbilical cord blood lipidome and infant birth weight

  Scientific Reports · 2020 · 55 citations

  Major alterations in metabolism occur during pregnancy enabling the mother to provide adequate nutrients to support infant development, affecting birth weight (BW) and potentially long-term risk of obesity and cardiometabolic disease. We classified dynamic changes in the maternal lipidome during pregnancy and identified lipids associated with Fenton BW z-score and the umbilical cord blood (CB) lipidome. Lipidomics was performed on first trimester maternal plasma (M1), delivery maternal plasma (M…

  DOI

• Integrating exposomics into biomedicine

  Science · 2025-04-24 · 51 citations

  articleOpen access

  Assessing a full range of environmental exposures will improve human health.

  PublisherOA PDFDOI

• Genome-Wide Epigenetic Signatures of Adaptive Developmental Plasticity in the Andes

  Genome Biology and Evolution · 2020 · 35 citations

  High-altitude adaptation is a classic example of natural selection operating on the human genome. Physiological and genetic adaptations have been documented in populations with a history of living at high altitude. However, the role of epigenetic gene regulation, including DNA methylation, in high-altitude adaptation is not well understood. We performed an epigenome-wide DNA methylation association study based on whole blood from 113 Peruvian Quechua with differential lifetime exposures to high…

  PublisherOA PDFDOI

• Neonatal Lead (Pb) Exposure and DNA Methylation Profiles in Dried Bloodspots

  International Journal of Environmental Research and Public Health · 2020 · 32 citations

  Senior authorCorresponding

  -value. In addition to increases/decreases in methylation, we also demonstrate that Pb exposure is related to increased variability in DNA methylation at 16 CpG sites. More work is needed to assess the accuracy and precision of metals assessment using bloodspots, but this study highlights the utility of this unique resource to enhance environmental epigenetics research around the world.

  DOI

Recent grants

• Environmental Epigenomics and Precision Environmental Health

  NIH · $6.1M · 2020–2028

• Integrated Health Sciences Core

  NIH · $33.1M · 2011–2027

• NIH Grant U2CES026553

  NIH · $19.0M · 2021

Frequent coauthors

• Jaclyn M. Goodrich

  114 shared

• Karen E. Peterson

  University of Michigan–Ann Arbor

  76 shared

• Maureen A. Sartor

  University of Michigan–Ann Arbor

  63 shared

• Muna S. Nahar

  Menlo School

  57 shared

• Justin A. Colacino

  University of Michigan–Ann Arbor

  42 shared

• Christopher Faulk

  University of Minnesota

  41 shared

• Tamara R. Jones

  University of Michigan–Ann Arbor

  38 shared

• Martha María Téllez‐Rojo

  Instituto Nacional de Salud Pública

  38 shared

Labs

• Dolinoy LabPI

Awards & honors

• Director of the University of Michigan NIEHS P30 Core Center…
• Member of the NIEHS TaRGET II Consortia
• MPI of the NIDDK R01 project 'Maternal Metabolic and Molecul…

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