Transsynaptic mapping of Drosophila mushroom body output neurons

eLife · 2021 · 62 citations

• Biology
• Neuroscience
• Cell biology

-Tango provides a genetically accessible anatomical framework for investigating the functional relevance of components within these complex and interconnected circuits.

Circuits that encode and guide alcohol-associated preference

eLife · 2020 · 50 citations

• Neuroscience
• Psychology
• Biology

. During memory expression, subsets of dopamine neurons directly and indirectly modulate the activity of interconnected glutamatergic and cholinergic mushroom body output neurons (MBON). Transsynaptic tracing of neurons important for memory expression revealed a convergent center of memory consolidation within the mushroom body (MB) implicated in arousal, and a structure outside the MB implicated in integration of naïve and learned responses. These findings provide a circuit framework through which dopamine neuronal activation shifts from reward delivery to cue onset, and provide insight into the maladaptive nature of memory.