Cindy Yang
· ProfessorCornell University · Pharmacology and Chemical Biology
Active 1994–2025
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About
Dr. Cindy Yang is a professor leading the Yang Lab at Weill Cornell Medicine. Her research builds upon the work of the late Dr. Anthony Sauve, focusing on investigating novel NAD⁺ compounds, their metabolic pathways, and the potential therapeutic benefits of altering NAD⁺ concentrations in cell and animal models. NAD⁺ is a vital coenzyme involved in energy metabolism, DNA repair, and cellular signaling. Her lab has developed synthetic methodologies for various novel NAD⁺ precursors, including dihydronicotinamide riboside (NRH), and has pioneered advanced techniques to study NAD⁺ metabolism, such as isotope syntheses for key precursors like nicotinamide, nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN). These tools enable comprehensive investigations of NAD⁺ metabolism both in vitro and in vivo. The lab aims to manipulate NAD⁺ concentrations in pathological conditions such as aging and metabolic diseases, with the goal of discovering new treatments to alleviate age-related and obesity-induced morbidities.
Research topics
- Biology
- Cell biology
- Genetics
- Computational biology
- Chemistry
- Cancer research
- Biochemistry
Selected publications
Nucleic Acids Research · 2020 · 35 citations
Human genome stability requires efficient repair of oxidized bases, which is initiated via damage recognition and excision by NEIL1 and other base excision repair (BER) pathway DNA glycosylases (DGs). However, the biological mechanisms underlying detection of damaged bases among the million-fold excess of undamaged bases remain enigmatic. Indeed, mutation rates vary greatly within individual genomes, and lesion recognition by purified DGs in the chromatin context is inefficient. Employing super-…
2025-11-24
articleOpen access<p>Supplementary Tables S1, S2, S5-S13 includes Supplementary Tables S1, S2, S5-S13. Supplementary Table S1 provides a summary of BL and DHL patient demographics for the immunohistochemistry study presented in Fig. 1, E and F. Supplementary Table S2 lists the MYC-dysregulated genes whose expression is significantly altered following depletion of eIF5A or DHPS, related to Fig. 4F. Supplementary Table S5 shows DHPS GISTIC count and survival of select TCGA PanCancer datasets, related to Fig.…
2025-11-24
articleOpen access<p>Supplementary Figures S1-S7 includes Supplementary Figure S1-S7 and the figure legend for each figure. Supplementary Fig. S1 shows that the polyamine-hypusine circuit is activated in many human cancers including MYC-driven lymphoma. Supplementary Fig. S1 is related to Fig. 1. Supplementary Fig. S2 shows that inhibition of DHPS enzyme activity, or silencing eIF5A or DHPS, suppresses the growth of mouse MYC-driven lymphoma. Supplementary Fig. S2 is related to Fig. 2. Supplementary Fig. S3…
2024-09-16
supplementary-materialsOpen access<p>Supplementary Table S4 lists oncogenes and tumor suppressor genes analyzed for changes in translation efficiency (TE) following depletion of eIF5A or DHPS, related to Fig. 5E.</p>
2024-09-16
supplementary-materialsOpen access<p>Supplementary Tables S1, S2, S5-S13 includes Supplementary Tables S1, S2, S5-S13. Supplementary Table S1 provides a summary of BL and DHL patient demographics for the immunohistochemistry study presented in Fig. 1, E and F. Supplementary Table S2 lists the MYC-dysregulated genes whose expression is significantly altered following depletion of eIF5A or DHPS, related to Fig. 4F. Supplementary Table S5 shows DHPS GISTIC count and survival of select TCGA PanCancer datasets, related to Fig.…
Frequent coauthors
- 161 shared
John L. Cleveland
- 84 shared
Bo Xu
Tianjin Medical University Cancer Institute and Hospital
- 77 shared
William Roush
Scripps Research Institute
- 64 shared
Anders Berglund
Moffitt Cancer Center
- 58 shared
Mohammad Fallahi
Tarbiat Modares University
- 57 shared
John M. Koomen
Molecular Oncology (United States)
- 54 shared
Robert J. Rounbehler
Clinical Insights
- 53 shared
Joanne R. Doherty
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