About

Dr. Samuel Jae Chung is an anesthesiologist affiliated with Johns Hopkins School of Medicine. He completed his residency in anesthesiology at Johns Hopkins University School of Medicine in 2005 and earned his MD from the University of Maryland School of Medicine in 2001. Dr. Chung is board certified in anesthesiology by the American Board of Anesthesiology since 2006. He practices at The Johns Hopkins Hospital in Baltimore, MD, and is involved in patient care within the Johns Hopkins health system. His professional focus includes anesthesiology, and he is recognized as a Johns Hopkins Physician, Clinician, or Researcher.

Research topics

• Medicine
• Internal medicine
• Endocrinology
• Pharmacology
• Dermatology
• Cardiology
• Pathology
• Statistics
• Mathematics

Selected publications

• Myo-inositol supplementation in gestational diabetes mellitus: is there any interference with diet?

  Frontiers in Nutrition · 2025-09-24 · 1 citations

  articleOpen access

  Background/objectives Gestational Diabetes Mellitus (GDM) affects 31.6% of pregnant women in Qatar. Myo-inositol (MI) supplementation has been proposed to reduce GDM risk, but its interaction with diet and lifestyle remains unclear. This study assessed the effects of physical activity and diet on MI supplementation and GDM onset throughout pregnancy. Subjects/methods A randomized double-blind clinical trial was conducted at Sidra Medicine hospital, involving pregnant women assigned to either the MI ( n = 31) or placebo (PLA, n = 33) arm. The Oral Glucose Tolerance Test (OGTT) was conducted between 24 and 28 weeks of gestation. Dietary intake was assessed using 24-h dietary recall and Food Frequency Questionnaires (FFQ), and physical activity and lifestyle data were collected using questionnaires at each trimester. Nutrient analysis was performed using Nutritionist Pro, and dietary patterns were evaluated using the Healthy Eating Index (HEI) and Dietary Inflammatory Index (DII). Statistical analysis was conducted using Prism GraphPad ( p ≤ 0.05). ISRCTN Registration number ISRCTN16448440. Results Dietary adjustments during pregnancy included increased protein and fiber intake, reduced salt, and higher consumption of simple sugars. The MI group showed higher physical activity (walking time/week), lower weight gain, and increased fiber intake (beans and tubers) compared to PLA, which consumed more high-fat, high-sugar foods. Despite these differences, no major differences in GDM incidence were observed between groups. Conclusion MI supplementation was associated with a healthier diet and higher physical activity. Findings suggest that an active lifestyle and balanced diet may enhance MI’s efficacy in lowering GDM risk. Further research is needed to clarify this relationship. Clinical trial registration The study Clinical trial registration ID is ISRCTN Registration number ISRCTN16448440.

  PublisherOA PDFDOI

• 516 Plasma cytokine analysis reveals blood eosinophil and race-based endotypes in prurigo nodularis

  Journal of Investigative Dermatology · 2024-07-19

  articleOpen access
  PublisherOA PDFDOI

• Characteristics associated with patient-reported treatment success in psoriatic arthritis

  Lara D. Veeken · 2024-03-08 · 3 citations

  article1st author

  OBJECTIVES: To determine characteristics associated with patient-reported treatment success in psoriatic arthritis (PsA). METHODS: Rheumatologist-diagnosed PsA patients fulfilling the CASPAR classification were recruited from a single center. PsA outcome measures included: 66/68 swollen/tender joint counts, Leeds/SPARCC dactylitis/enthesitis indices, psoriasis body surface area (BSA), and patient-reported outcomes (PROs) including PROMIS. The primary outcome was a patient-reported item: 'Today, considering the level of control of your psoriatic arthritis and psoriasis, do you consider your treatment has been successful?'. Descriptive and multivariate logistic regression analyses identified clinical predictors of patient-reported treatment success. Patient-reported reasons for lack of treatment success were explored. RESULTS: A total of 178 participants had a baseline visit. Mean (SD) CASPAR score was 3.7 (0.9), age 51.7 (13.5) years, and BMI 31.3 (7.2) kg/m2. Fifty-two percent were women, and 86.0% white. Treatment success was reported by 116/178 (65%) patients in the analytic cohort. Among 76 patients who reported treatment failure, the most frequently selected reasons for lack of success were pain (n = 55, 72.4%), fatigue (n = 46, 60.5%), inflamed joints (n = 40, 52.6%) and stiffness (n = 40, 52.6%). Overall, 105 participants had complete data across variables in the logistic regression models. Patient-reported treatment success was independently associated with the 66-swollen/68-tender joint counts, psoriasis BSA, PROs (pain interference, physical function, fatigue) and TNF-inhibitor therapy, after controlling for BMI and demographics. CONCLUSION: Patient-reported treatment success in PsA may be achieved through improvement of inflammatory arthritis, psoriasis, pain, physical function, fatigue and the use of TNF-inhibitors. Patients reported treatment failure was most commonly due to symptoms of pain, fatigue and stiffness.

  PublisherDOI

• Targeting the Angiotensin AT2 Receptor to Treat Cardiac Fibrosis and Heart Failure

  Heart Lung and Circulation · 2024-07-28

  articleOpen access
  PublisherOA PDFDOI

• Comprehensive plasma cytokine and chemokine profiling in prurigo nodularis reveals endotypes in Type 2 inflammation

  Scientific Reports · 2024-04-06 · 14 citations

  articleOpen access

  Prurigo nodularis (PN) is a chronic inflammatory skin disease that is associated with variability in peripheral blood eosinophil levels and response to T-helper 2 targeted therapies (Th2). Our objective was to determine whether circulating immune profiles with respect to type 2 inflammation differ by race and peripheral blood eosinophil count. Plasma from 56 PN patients and 13 matched healthy controls was assayed for 54 inflammatory biomarkers. We compared biomarker levels between PN and HCs, among PN patients based on absolute eosinophil count, and across racial groups in PN. Eleven biomarkers were elevated in PN versus HCs including interleukin (IL)-12/IL-23p40, tumor necrosis factor-alpha (TNF-α), Thymic stromal lymphopoietin (TSLP), and macrophage-derived chemokine (MDC/CCL22). Additionally, PN patients with AEC > 0.3 K cells/μL had higher Th2 markers (eotaxin, eotaxin-3, TSLP, MCP-4/CCL13), and African American PN patients had lower eosinophils, eotaxin, and eotaxin-3 versus Caucasian and Asian PN patients (p < 0.05 for all). Dupilumab responders had higher AEC (p < 0.01), were more likely to be Caucasian (p = 0.02) or Asian (p = 0.05) compared to African Americans, and more often had a history of atopy (p = 0.08). This study suggests that blood AEC > 0.3 K and Asian and Caucasian races are associated with Th2 skewed circulating immune profiles and response to Th2 targeted therapies.

  PublisherOA PDFDOI

• Accuracy of 23 Equations for Estimating LDL Cholesterol in a Clinical Laboratory Database of 5,051,467 Patients

  Global Heart · 2023 · 45 citations

  1st authorCorresponding
  • Medicine
  • Internal medicine
  • Endocrinology

  Background: Alternatives to the Friedewald low-density lipoprotein cholesterol (LDL-C) equation have been proposed. Objective: To compare the accuracy of available LDL-C equations with ultracentrifugation measurement. Methods: We used the second harvest of the Very Large Database of Lipids (VLDbL), which is a population-representative convenience sample of adult and pediatric patients (N = 5,051,467) with clinical lipid measurements obtained via the vertical auto profile (VAP) ultracentrifugation method between October 1, 2015 and June 30, 2019. We performed a systematic literature review to identify available LDL-C equations and compared their accuracy according to guideline-based classification. We also compared the equations by their median error versus ultracentrifugation. We evaluated LDL-C equations overall and stratified by age, sex, fasting status, and triglyceride levels, as well as in patients with atherosclerotic cardiovascular disease, hypertension, diabetes, kidney disease, inflammation, and thyroid dysfunction. Results: Analyzing 23 identified LDL-C equations in 5,051,467 patients (mean±SD age, 56±16 years; 53.3% women), the Martin/Hopkins equation most accurately classified LDL-C to the correct category (89.6%), followed by the Sampson (86.3%), Chen (84.4%), Puavilai (84.1%), Delong (83.3%), and Friedewald (83.2%) equations. The other 17 equations were less accurate than Friedewald, with accuracy as low as 35.1%. The median error of equations ranged from -10.8 to 18.7 mg/dL, and was best optimized using the Martin/Hopkins equation (0.3, IQR-1.6 to 2.4 mg/dL). The Martin/Hopkins equation had the highest accuracy after stratifying by age, sex, fasting status, triglyceride levels, and clinical subgroups. In addition, one in five patients who had Friedewald LDL-C <70 mg/dL, and almost half of the patients with Friedewald LDL-C <70 mg/dL and triglyceride levels 150-399 mg/dL, had LDL-C correctly reclassified to >70 mg/dL by the Martin/Hopkins equation. Conclusions: Most proposed alternatives to the Friedewald equation worsen LDL-C accuracy, and their use could introduce unintended disparities in clinical care. The Martin/Hopkins equation demonstrated the highest LDL-C accuracy overall and across subgroups.

  PublisherOA PDFDOI

• Topical GZ21T Inhibits the Growth of Actinic Keratoses in a UVB-Induced Model of Skin Carcinogenesis

  JID Innovations · 2023-05-05 · 2 citations

  articleOpen access

  = 0.016) signaling. GZ21T also upregulated the autophagy-promoting protein AMPK while suppressing proteins such as PD-L1, glutaminase, pAkt1 S473, and eEF2K.

  PublisherDOI

• ISIDLB1689 - Predictors of mortality in DRESS-associated myocarditis: a systemiatic review

  2023-05-05

  review1st authorCorresponding
  PublisherDOI

• LB1689 Predictors of mortality in DRESS-associated myocarditis: A systemiatic review

  Journal of Investigative Dermatology · 2023-08-21

  reviewOpen access1st authorCorresponding
  PublisherOA PDFDOI

• POS0883 PREDICTORS OF PATIENT-REPORTED TREATMENT SUCCESS IN PATIENTS WITH PSORIATIC ARTHRITIS

  Annals of the Rheumatic Diseases · 2023-06-01

  articleOpen access1st authorCorresponding
  PublisherOA PDFDOI

Frequent coauthors

• Shawn G. Kwatra

  University of Maryland, Baltimore

  12 shared

• Zachary A. Bordeaux

  Johns Hopkins Medicine

  12 shared

• Justin Choi

  Johns Hopkins University

  12 shared

• Kevin K. Lee

  Johns Hopkins Medicine

  12 shared

• Hannah Cornman

  University of Maryland, Baltimore

  11 shared

• Weiying Lu

  Johns Hopkins Medicine

  10 shared

• Sriya V. Reddy

  Johns Hopkins University

  10 shared

• Anusha Kambala

  Johns Hopkins Medicine

  9 shared