Carolyn Mills
· Assistant Professor of BioengineeringUniversity of California, Santa Barbara · Bioengineering
Active 1951–2024
About
Dr. Carolyn Mills (she/they) is an Assistant Professor in the Department of Biological Engineering at the University of California, Santa Barbara (UCSB). Her research focuses on the molecular engineering of proteins that control spatial organization in biological systems, with applications in plastic remediation and oral vaccine delivery. Carolyn completed her B.S. in Chemical Engineering at UCSB in 2013, where she conducted research using atomistic simulations to study peptide self-assembly with Professor M. Scott Shell. She earned her PhD in Chemical Engineering from the Massachusetts Institute of Technology in 2019, working in Professor Bradley Olsen’s lab on self-assembly and high-throughput processing of fusion protein materials. During her PhD, she was supported by an NSF Graduate Research Fellowship and was a finalist in the Excellence in Graduate Polymer Research session at the AIChE National Meeting in 2018. Her postdoctoral work was conducted with Professor Danielle Tullman-Ercek at Northwestern University, where she researched self-assembling protein nanoreactors with a focus on their applications in metabolic engineering. She organized the inaugural Context, Community, and Connections Symposium (C3S) at Northwestern to highlight research by underrepresented groups in chemical engineering, chemistry, and materials science, and received the Chemical and Biological Engineering Department’s Distinguished Postdoctoral Service Award. Her lab is dedicated to studying and engineering protein assemblies to address global challenges such as plastic waste remediation, biological liquid-liquid phase separation, and oral vaccine development, leveraging expertise in protein engineering, soft matter, and synthetic biology to develop low-cost, accessible solutions.
Research topics
- Physics
- Nuclear physics
- Particle physics
- Computer Science
- Optics
- Astrophysics
- Algorithm
- Artificial Intelligence
- Operating system
- Mechanics
- Geography
Selected publications
Search for exotic decays of the Higgs boson to a pair of pseudoscalars in the $\mu\mu$bb and $\tau\tau$bb final states
2024
- Physics
- Particle physics
- Nuclear physics
A search for exotic decays of the Higgs boson (H) with a mass of 125 GeV to a pair of light pseudoscalars $\mathrm{a}_1$ is performed in final states where one pseudoscalar decays to two b quarks and the other to a pair of muons or $\tau$ leptons. A data sample of proton-proton collisions at $\sqrt{s}$ = 13 TeV corresponding to an integrated luminosity of 138 fb$^{-1}$ recorded with the CMS detector is analyzed. No statistically significant excess is observed over the standard model backgrounds. Upper limits are set at 95% confidence level (CL) on the Higgs boson branching fraction to $\mu\mu$bb and to $\tau\tau$bb, via a pair of $\mathrm{a}_1$s. The limits depend on the pseudoscalar mass $m_{\mathrm{a}_1}$ and are observed to be in the range (0.17-3.3) $\times$ 10$^{-4}$ and (1.7-7.7) $\times$ 10$^{2}$ in the $\mu\mu$bb and $\tau\tau$bb final states, respectively. In the framework of models with two Higgs doublets and a complex scalar singlet (2HDM+S), the results of the two final states are combined to determine model-independent upper limits on the branching fraction $\mathcal{B}$(H $\to$ $\mathrm{a}_1\mathrm{a}_1$ $\to$ $\ell\ell$bb) at 95% CL, with $\ell$ being a muon or a $\tau$ lepton. For different types of 2HDM+S, upper bounds on the branching fraction $\mathcal{B}$(H $\to$ $\mathrm{a}_1\mathrm{a}_1$) are extracted from the combination of the two channels. In most of the Type II 2HDM+S parameter space, $\mathcal{B}($H $\to$ $\mathrm{a}_1\mathrm{a}_1$) values above 0.23 are excluded at 95% CL for $m_{\mathrm{a}_1}$ values between 15 and 60 GeV.
Physical Review Letters · 2024 · 96 citations
- Physics
A search is reported for near-threshold structures in the J/ψJ/ψ invariant mass spectrum produced in proton-proton collisions at sqrt[s]=13 TeV from data collected by the CMS experiment, corresponding to an integrated luminosity of 135 fb^{-1}. Three structures are found, and a model with quantum interference among these structures provides a good description of the data. A new structure is observed with a local significance above 5 standard deviations at a mass of 6638_{-38}^{+43}(stat)_{-31}^{+16}(syst) MeV. Another structure with even higher significance is found at a mass of 6847_{-28}^{+44}(stat)_{-20}^{+48}(syst) MeV, which is consistent with the X(6900) resonance reported by the LHCb experiment and confirmed by the ATLAS experiment. Evidence for another new structure, with a local significance of 4.7 standard deviations, is found at a mass of 7134_{-25}^{+48}(stat)_{-15}^{+41}(syst) MeV. Results are also reported for a model without interference, which does not fit the data as well and shows mass shifts up to 150 MeV relative to the model with interference.
arXiv (Cornell University) · 2024 · 6 citations
- Physics
- Particle physics
- Nuclear physics
A bstract An inclusive search for long-lived exotic particles (LLPs) decaying to final states with a pair of muons is presented. The search uses data corresponding to an integrated luminosity of 36.6 fb − 1 collected by the CMS experiment from the proton-proton collisions at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13.6 TeV in 2022, the first year of Run 3 of the CERN LHC. The experimental signature is a pair of oppositely charged muons originating from a secondary vertex spatially separated from the proton-proton interaction point by distances ranging from several hundred μ m to several meters. The sensitivity of the search benefits from new triggers for displaced dimuons developed for Run 3. The results are interpreted in the framework of the hidden Abelian Higgs model, in which the Higgs boson decays to a pair of long-lived dark photons, and of an R -parity violating supersymmetry model, in which long-lived neutralinos decay to a pair of muons and a neutrino. The limits set on these models are the most stringent to date in wide regions of lifetimes for LLPs with masses larger than 10 GeV.
arXiv (Cornell University) · 2023 · 1 citations
- Physics
- Particle physics
- Nuclear physics
A search for long-lived heavy neutral leptons (HNLs) is presented, which considers the hadronic final state and coupling scenarios involving all three lepton generations in the 2-20 GeV HNL mass range for the first time. Events comprising two leptons (electrons or muons) and jets are analyzed in a data sample of proton-proton collisions, recorded with the CMS experiment at the CERN LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 138 fb$^{-1}$. A novel jet tagger, based on a deep neural network, has been developed to identify jets from an HNL decay using various features of the jet and its constituent particles. The network output can be used as a powerful discriminating tool to probe a broad range of HNL lifetimes and masses. Contributions from background processes are determined from data. No excess of events in data over the expected background is observed. Upper limits on the HNL production cross section are derived as functions of the HNL mass and the three coupling strengths $V_{\ell\mathrm{N}}$ to each lepton generation $\ell$ and presented as exclusion limits in the coupling-mass plane, as lower limits on the HNL lifetime, and on the HNL mass. In this search, the most stringent limit on the coupling strength is obtained for pure muon coupling scenarios; values of $\lvert V_{\mu\mathrm{N}}\rvert^{2}\gt $ 5 (4)$\times$10$^{-7}$ are excluded for Dirac (Majorana) HNLs with a mass of 10 GeV at a confidence level of 95% that correspond to proper decay lengths of 17 (10) mm.
Journal of High Energy Physics · 2023 · 69 citations
- Physics
- Particle physics
- Nuclear physics
A bstract Three searches are presented for signatures of physics beyond the standard model (SM) in ττ final states in proton-proton collisions at the LHC, using a data sample collected with the CMS detector at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13 TeV, corresponding to an integrated luminosity of 138 fb − 1 . Upper limits at 95% confidence level (CL) are set on the products of the branching fraction for the decay into τ leptons and the cross sections for the production of a new boson ϕ , in addition to the H(125) boson, via gluon fusion (gg ϕ ) or in association with b quarks, ranging from $$ \mathcal{O} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>O</mml:mi> </mml:math> (10 pb) for a mass of 60 GeV to 0.3 fb for a mass of 3.5 TeV each. The data reveal two excesses for gg ϕ production with local p -values equivalent to about three standard deviations at m ϕ = 0 . 1 and 1.2 TeV. In a search for t -channel exchange of a vector leptoquark U 1 , 95% CL upper limits are set on the dimensionless U 1 leptoquark coupling to quarks and τ leptons ranging from 1 for a mass of 1 TeV to 6 for a mass of 5 TeV, depending on the scenario. In the interpretations of the $$ {M}_{\textrm{h}}^{125} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mi>M</mml:mi> <mml:mi>h</mml:mi> <mml:mn>125</mml:mn> </mml:msubsup> </mml:math> and $$ {M}_{\textrm{h},\textrm{EFT}}^{125} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mi>M</mml:mi> <mml:mrow> <mml:mi>h</mml:mi> <mml:mo>,</mml:mo> <mml:mi>EFT</mml:mi> </mml:mrow> <mml:mn>125</mml:mn> </mml:msubsup> </mml:math> minimal supersymmetric SM benchmark scenarios, additional Higgs bosons with masses below 350 GeV are excluded at 95% CL.
Physics Letters B · 2023 · 75 citations
- Computer Science
- Physics
- Algorithm
Measurements are presented of the Bs0→μ+μ− branching fraction and effective lifetime, as well as results of a search for the B0→μ+μ− decay in proton-proton collisions at s=13TeV at the LHC. The analysis is based on data collected with the CMS detector in 2016–2018 corresponding to an integrated luminosity of 140fb−1. The branching fraction of the Bs0→μ+μ− decay and the effective Bs0 meson lifetime are the most precise single measurements to date. No evidence for the B0→μ+μ− decay has been found. All results are found to be consistent with the standard model predictions and previous measurements.
A portrait of the Higgs boson by the CMS experiment ten years after the discovery
Nature · 2022 · 320 citations
- Physics
- Particle physics
- Nuclear physics
In July 2012, the ATLAS and CMS collaborations at the CERN Large Hadron Collider announced the observation of a Higgs boson at a mass of around 125 gigaelectronvolts. Ten years later, and with the data corresponding to the production of a 30-times larger number of Higgs bosons, we have learnt much more about the properties of the Higgs boson. The CMS experiment has observed the Higgs boson in numerous fermionic and bosonic decay channels, established its spin-parity quantum numbers, determined its mass and measured its production cross-sections in various modes. Here the CMS Collaboration reports the most up-to-date combination of results on the properties of the Higgs boson, including the most stringent limit on the cross-section for the production of a pair of Higgs bosons, on the basis of data from proton-proton collisions at a centre-of-mass energy of 13 teraelectronvolts. Within the uncertainties, all these observations are compatible with the predictions of the standard model of elementary particle physics. Much evidence points to the fact that the standard model is a low-energy approximation of a more comprehensive theory. Several of the standard model issues originate in the sector of Higgs boson physics. An order of magnitude larger number of Higgs bosons, expected to be examined over the next 15 years, will help deepen our understanding of this crucial sector.
arXiv (Cornell University) · 2022 · 2 citations
- Physics
- Particle physics
- Nuclear physics
The first search is presented for vector-like leptons (VLLs) in the context of the '4321 model', an ultraviolet-complete model with the potential to explain existing B physics measurements that are in tension with standard model predictions. The analyzed data, corresponding to an integrated luminosity of 96.5 fb$^{-1}$, were recorded in 2017 and 2018 with the CMS detector at the LHC in proton-proton collisions at $\sqrt{s}$ =13 TeV. Final states with ${\geq}$3 b-tagged jets and two third-generation leptons ($\tau\tau$, $\tau\nu_\tau$, or $\nu_\tau\nu_\tau$) are considered. Upper limits are derived on the VLL production cross section in the VLL mass range 500-1050 GeV. The maximum likelihood fit prefers the presence of signal at the level of 2.8 standard deviations, for a representative VLL mass point of 600 GeV. As a consequence, the observed upper limits are approximately double the expected limits.
The CMS Phase-1 pixel detector upgrade
Journal of Instrumentation · 2021 · 93 citations
- Computer Science
- Physics
- Optics
The CMS Phase-1 pixel detector
arXiv (Cornell University) · 2021 · 4 citations
- Physics
- Particle physics
- Nuclear physics
A search for exclusive two-photon production via photon exchange in proton-proton collisions, pp $\to$ p$\gamma\gamma$p with intact protons, is presented. The data correspond to an integrated luminosity of 9.4 fb$^{-1}$ collected in 2016 using the CMS and TOTEM detectors at a center-of-mass energy of 13 TeV at the LHC. Events are selected with a diphoton invariant mass above 350 GeV and with both protons intact in the final state, to reduce backgrounds from strong interactions. The events of interest are those where the invariant mass and rapidity calculated from the momentum losses of the forward-moving protons matches the mass and rapidity of the central, two-photon system. No events are found that satisfy this condition. Interpreting this result in an effective dimension-8 extension of the standard model, the first limits are set on the two anomalous four-photon coupling parameters. If the other parameter is constrained to its standard model value, the limits at 95% CL are $\lvert\zeta_1\rvert\lt$ 2.88$\times$10$^{-13}$ GeV$^{-4}$ and $\lvert\zeta_2\rvert\lt$6.02$\times$10$^{-13}$GeV$^{-4}$.
Frequent coauthors
- 1103 shared
M. Titov
Institut de Recherche sur les Lois Fondamentales de l'Univers
- 1085 shared
G. Hamel de Monchenault
Université Paris-Saclay
- 1045 shared
A. Rosowsky
Institut de Recherche sur les Lois Fondamentales de l'Univers
- 1039 shared
M. Besançon
CEA Paris-Saclay
- 1006 shared
F. Couderc
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
- 990 shared
M. Costa
Istituto Nazionale di Fisica Nucleare, Sezione di Torino
- 955 shared
C. Amendola
CEA Paris-Saclay
- 909 shared
S. De Cecco
Radboud University Nijmegen
Education
- 2013
B.S., Chemical Engineering
University of California, Santa Barbara (UCSB)
- 2019
Ph.D., Chemical Engineering
Massachusetts Institute of Technology (MIT)
Other
Northwestern University
Awards & honors
- NSF Graduate Research Fellowship
- Finalist in the Excellence in Graduate Polymer Research sess…
- Chemical and Biological Engineering Department’s Distinguish…
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