Carol Greider

About

Carol Greider is a Distinguished Professor of Molecular, Cell and Developmental Biology. She earned her B.A. in Biology from the University of California, Santa Barbara, and her Ph.D. in Molecular Biology from the University of California, Berkeley. She is a Fellow at Cold Spring Harbor Laboratory and was awarded the Nobel Prize in Physiology or Medicine in 2009. Her professional contact is cgreider@ucsc.edu. The GreiderLab, led by Professor Greider, has a significant impact on the scientific community, particularly in the field of telomere and telomerase research, as evidenced by the extensive academic genealogy and alumni network associated with her lab.

Research topics

• Biology
• Genetics
• Computational biology

Selected publications

• Human telomere length is chromosome end–specific and conserved across individuals

  Science · 2024-04-11 · 77 citations

  articleOpen accessSenior authorCorresponding

  Short telomeres cause age-related disease, and long telomeres contribute to cancer; however, the mechanisms regulating telomere length are unclear. We developed a nanopore-based method, which we call Telomere Profiling, to determine telomere length at nearly single-nucleotide resolution. Mapping telomere reads to chromosome ends showed chromosome end-specific length distributions that could differ by more than six kilobases. Examination of telomere lengths in 147 individuals revealed that certai…

  PublisherOA PDFDOI

• Chromosome-specific telomere lengths and the minimal functional telomere revealed by nanopore sequencing

  Genome Research · 2021 · 70 citations

  Senior authorCorresponding

  double mutants. The rate of telomere shortening in the absence of telomerase was similar across all chromosome ends at ∼5 bp per generation. This new method gives quantitative, high-resolution telomere length measurement at each individual chromosome end and suggests possible new biological mechanisms regulating telomere length.

  PublisherOA PDFDOI

• TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma

  Science · 2022-11-10 · 39 citations

  articleOpen accessCorresponding

  Overcoming replicative senescence is an essential step during oncogenesis, and the reactivation of TERT through promoter mutations is a common mechanism. TERT promoter mutations are acquired in about 75% of melanomas but are not sufficient to maintain telomeres, suggesting that additional mutations are required. We identified a cluster of variants in the promoter of ACD encoding the shelterin component TPP1. ACD promoter variants are present in about 5% of cutaneous melanoma and co-occur with TE…

  PublisherOA PDFDOI

• Rif1 regulates telomere length through conserved HEAT repeats

  Nucleic Acids Research · 2021-03-23 · 10 citations

  articleOpen accessSenior authorCorresponding

  In budding yeast, Rif1 negatively regulates telomere length, but the mechanism of this regulation has remained elusive. Previous work identified several functional domains of Rif1, but none of these has been shown to mediate telomere length. To define Rif1 domains responsible for telomere regulation, we localized truncations of Rif1 to a single specific telomere and measured telomere length of that telomere compared to bulk telomeres. We found that a domain in the N-terminus containing HEAT repe…

  PublisherOA PDFDOI

• Chromosome specific telomere lengths and the minimal functional telomere revealed by nanopore sequencing

  bioRxiv (Cold Spring Harbor Laboratory) · 2021-06-07 · 8 citations

  preprintOpen accessSenior authorCorresponding

  ABSTRACT We developed a method to tag telomeres and measure telomere length by nanopore sequencing in the yeast S. cerevisiae. Nanopore allows long read sequencing through the telomere, subtelomere and into unique chromosomal sequence, enabling assignment of telomere length to a specific chromosome end. We observed chromosome end specific telomere lengths that were stable over 120 cell divisions. These stable chromosome specific telomere lengths may be explained by stochastic clonal variation or…

  PublisherOA PDFDOI

Recent grants

• Project 2: Splicing Dysregulation in Cancer

  NIH · $257.8M · 1997–2028

• NIH Grant R01AG009383

  NIH · $1.6M · 2001

• Telomeres and Telomerase in Cancer

  NIH · $6.3M · 2017–2024

Frequent coauthors

• Margaret A. Strong

  Johns Hopkins Medicine

  72 shared

• Mary Armanios

  Johns Hopkins University

  42 shared

• Carla J. Connelly

  Johns Hopkins University

  38 shared

• Samantha L. Sholes

  Johns Hopkins University

  36 shared

• Julian J.‐L. Chen

  Arizona State University

  33 shared

• Calvin B. Harley

  32 shared

• Jonathan K. Alder

  University of Pittsburgh

  30 shared

• Karen R. Prowse

  29 shared

Labs

• GreiderLabPI

  This is meta description

Education

• Ph.D., Molecular Biology

  Johns Hopkins University

  1987

• B.A., Zoology

  Columbia University

  1980

Similar researchers at University of California, Santa Cruz

• John Tamkunh-55
• William Sullivanh-55
• Todd M. Loweh-47