Camila U. Braz

About

Camila U. Braz is a Principal Investigator at the Department of Animal Sciences at the University of Illinois, Urbana. Her research focuses on Bioinformatics and Computational Biology, as indicated by her role and the lab's specialization. She is involved in bioinformatics research within the Braz Lab, contributing to the understanding of biological data through computational methods. Her contact information is provided as cbraz@illinois.edu, and she is associated with the Illinois Bioinformatics and Computational Biology community.

Research topics

• Genetics
• Biology
• Cell biology
• Computational biology
• Molecular biology

Selected publications

• RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis

  The FASEB Journal · 2022 · 27 citations

  Arginine-serine (RS) domain(s) in splicing factors are critical for protein-protein interaction in pre-mRNA splicing. Phosphorylation of RS domain is important for splicing control and nucleocytoplasmic transport in the cell. RNA-binding motif 20 (RBM20) is a splicing factor primarily expressed in the heart. A previous study using phospho-antibody against RS domain showed that RS domain can be phosphorylated. However, its actual phosphorylation sites and function have not been characterized. Usi…

  DOI

• Disruption of the nuclear localization signal in RBM20 is causative in dilated cardiomyopathy

  JCI Insight · 2023-05-23 · 16 citations

  articleOpen access

  Human patients carrying genetic mutations in RNA binding motif 20 (RBM20) develop a clinically aggressive dilated cardiomyopathy (DCM). Genetic mutation knockin (KI) animal models imply that altered function of the arginine-serine-rich (RS) domain is crucial for severe DCM. To test this hypothesis, we generated an RS domain deletion mouse model (Rbm20ΔRS). We showed that Rbm20ΔRS mice manifested DCM with mis-splicing of RBM20 target transcripts. We found that RBM20 was mis-localized to the sarco…

  PublisherOA PDFDOI

• Characterization of genomic regions escaping epigenetic reprogramming in sheep

  Current Zoology · 2023-12-20 · 16 citations

  articleOpen access1st author

  The mammalian genome undergoes two global epigenetic reprogramming events during the establishment of primordial germ cells and in the pre-implantation embryo after fertilization. These events involve the erasure and re-establishment of DNA methylation marks. However, imprinted genes and transposable elements (TEs) maintain their DNA methylation signatures to ensure normal embryonic development and genome stability. Despite extensive research in mice and humans, there is limited knowledge regard…

  PublisherOA PDFDOI

• Transgenerational Epigenetic and Phenotypic Inheritance Across Five Generations in Sheep

  International Journal of Molecular Sciences · 2025-07-03 · 7 citations

  articleOpen access

  Despite two extensive reprogramming events during early embryogenesis and gametogenesis, epigenetic information can be passed to the next generations, which constitutes the transgenerational epigenetic inheritance of phenotypes. Considering its utmost importance, there have been few studies focused on the transgenerational effects of dietary interventions, such as methionine supplementation, in livestock. Using whole-genome bisulfite sequencing, we implemented a single-base resolution differenti…

  PublisherOA PDFDOI

• Unraveling metabolic stress response in dairy cows: Genetic control of plasma biomarkers throughout lactation and the transition period

  Journal of Dairy Science · 2024-06-28 · 5 citations

  articleOpen access

  Breeding animals able to effectively respond to stress could be a long-term, sustainable, and affordable strategy to improve resilience and welfare in livestock systems. In the present study, the concentrations of 29 plasma biomarkers were used as candidate endophenotypes for metabolic stress response in single-SNP, gene- and haplotype-based GWAS using 739 healthy lactating Italian Holstein cows and 88,271 variants. Significant genetic associations were found in all the 3 GWAS approaches for pla…

  PublisherOA PDFDOI

Frequent coauthors

• Lúcia Galvão de Albuquerque

  23 shared

• Tiago Bresolin

  University of Illinois Urbana-Champaign

  16 shared

• Fernando Baldi

  Universidade Estadual Paulista (Unesp)

  13 shared

• Henrique Nunes de Oliveira

  12 shared

• Diércles F. Cardoso

  Universidade Estadual Paulista (Unesp)

  9 shared

• Hasan Khatib

  University of Wisconsin–Madison

  9 shared

• Wei Guo

  University of Wisconsin–Madison

  8 shared

• Roberto Carvalheiro

  Universidade Estadual Paulista (Unesp)

  8 shared

Labs

• Braz LabPI

Awards & honors

• Fellowship Baker Graduate Fellowships
• Clark Fellowship in Applied Dairy Cattle Nutrition
• Jonathan Baldwin Turner (JBT) Fellowships
• Dr. Carl Lee Davis Graduate Student Research Award in Dairy…
• Dr. James E. Corbin Companion Animal Biology Travel Scholars…

Similar researchers at University of Illinois Urbana-Champaign

• Isaac Cannh-55
• Dan Shikeh-19