Sang Kim
· Clinical AssociateVerifiedUniversity of Pennsylvania · Oral & Maxillofacial Surgery / Pharmacology
Active 1977–2026
About
Sang Y. Kim is a Clinical Associate in the Department of Oral & Maxillofacial Surgery / Pharmacology at Penn Dental Medicine. His professional focus includes clinical practice and research within the fields of oral and maxillofacial surgery and pharmacology. The page indicates his association with Penn Dental Medicine, located at the University of Pennsylvania, and highlights his role within the faculty, contributing to the academic and clinical missions of the institution.
Research topics
- Medicine
- Dentistry
- Materials science
- Chemistry
- Physics
Selected publications
Naringenin ameliorates swine pulpitis by modulating immune response
BMC Oral Health · 2026-04-13
articleOpen accessPreserving dental pulp vitality is crucial for maintaining the physiological function of the tooth. Naringenin (Nar), known for its immunomodulatory properties, has shown pharmacological effects on various inflammatory diseases. This study aimed to investigate the therapeutic potential of Nar in treating Porphyromonas gingivalis lipopolysaccharide (P.g-LPS)-induced pulpitis in a swine model and to elucidate the mechanisms underlying its therapeutic efficacy. Swine premolars with P.g-LPS-induced pulpitis were divided into four groups: sham, hydrogel, iRoot BP PLUS, and Nar hydrogel. Treatment outcomes were evaluated by assessing neutrophil infiltration, dentin-like tissue regeneration, and coronal pulp tissue preservation using histological and immunohistochemical techniques. To further examine potential cellular responses, the effects of Nar were studied in human dental pulp fibroblasts (hDPFs), human peripheral blood-derived neutrophils (hNeu.), and differentiated HL-60 cells (dHL-60). Surface markers were analyzed using fluorescence-activated cell sorting (FACS), cytokine levels were measured by ELISA, and mineralization was assessed using alkaline phosphatase and Alizarin Red S staining. Neutrophil phagocytosis, bactericidal activity, intracellular reactive oxygen species (ROS) levels, and translocation of transcription factor EB (TFEB)-mediated lysosomal activity were evaluated. Statistical analyses included Shapiro-Wilk test and one-way ANOVA or Kruskal-Wallis test with appropriate post hoc comparisons. The sham group showed severe pulp tissue necrosis and an intense inflammatory response. Hydrogel alone exhibited limited therapeutic effects. Both Nar hydrogel and iRoot BP PLUS promoted dentin-like tissue formation; however, Nar hydrogel reduced inflammatory infiltration and preserved a greater proportion of coronal pulp tissue. In vitro, Nar reduced inflammatory cytokine secretion from hDPFs and neutrophils and improved P.g-LPS-impaired mineralization capacity in hDPFs. Nar also enhanced the phagocytic and bactericidal activities of dHL-60 cells, accompanied by controlled ROS elevation and increased TFEB-mediated lysosomal activity. Nar demonstrates therapeutic potential for pulpitis management by modulating inflammation and promoting dentin-like tissue regeneration. Its efficacy likely stems from the fine-tuning of inflammatory responses. These findings suggest that Nar may represent a potential biological alternative to conventional pulp capping materials for vital pulp therapy.
Preserving the Natural Tooth Versus Extraction and Implant Placement: An Evidence-Based Approach
2026-01-01
book-chapterSenior authorJournal of Physics Conference Series · 2025-11-01
articleOpen accessAbstract The aim of the GBAR experiment is to measure the gravitational acceleration of antihydrogen by observing the free fall of ultracold anti-atoms. The experiment is installed at CERN’s Antiproton Decelerator/ELENA facility. Positrons are produced by a low energy (9 MeV) linear electron accelerator and captured in a modified Surko (buffer gas) trap. We have recently implemented a silicon carbide-based trapping scheme that replaces the routinely used nitrogen gas with a high quality silicon carbide single crystal in the first phase of the trap. The new setup has been providing stable and efficient positron trapping for more than a year. After a short accumulation in the buffer gas trap, the particles are transported to a high-field (5 T) Penning-Malmberg trap, where a high number of pulses can be collected in a deep potential well. We discuss the performance of the improved positron line and the present status of the experiment.
Differentiation of iPSC for potential cell-based regenerative endodontic therapy
Dental Materials · 2025-01-01
articleEndodontic microsurgery: Current trends and future outlook
Translational dental research. · 2025-04-01
articleOpen access1st authorCorrespondingPhysical Review Letters · 2024-08-23 · 10 citations
articleOpen accessThe neutron-rich unbound fluorine isotope ^{30}F_{21} has been observed for the first time by measuring its neutron decay at the SAMURAI spectrometer (RIBF, RIKEN) in the quasifree proton knockout reaction of ^{31}Ne nuclei at 235 MeV/nucleon. The mass and thus one-neutron-separation energy of ^{30}F has been determined to be S_{n}=-472±58(stat)±33(sys) keV from the measurement of its invariant-mass spectrum. The absence of a sharp drop in S_{n}(^{30}F) shows that the "magic" N=20 shell gap is not restored close to ^{28}O, which is in agreement with our shell-model calculations that predict a near degeneracy between the neutron d and fp orbitals, with the 1p_{3/2} and 1p_{1/2} orbitals becoming more bound than the 0f_{7/2} one. This degeneracy and reordering of orbitals has two potential consequences: ^{28}O behaves like a strongly superfluid nucleus with neutron pairs scattering across shells, and both ^{29,31}F appear to be good two-neutron halo-nucleus candidates.
Nature · 2023-08-30 · 59 citations
articleOpen accessAbstract Subjecting a physical system to extreme conditions is one of the means often used to obtain a better understanding and deeper insight into its organization and structure. In the case of the atomic nucleus, one such approach is to investigate isotopes that have very different neutron-to-proton ( N / Z ) ratios than in stable nuclei. Light, neutron-rich isotopes exhibit the most asymmetric N / Z ratios and those lying beyond the limits of binding, which undergo spontaneous neutron emission and exist only as very short-lived resonances (about 10 −21 s), provide the most stringent tests of modern nuclear-structure theories. Here we report on the first observation of 28 O and 27 O through their decay into 24 O and four and three neutrons, respectively. The 28 O nucleus is of particular interest as, with the Z = 8 and N = 20 magic numbers 1,2 , it is expected in the standard shell-model picture of nuclear structure to be one of a relatively small number of so-called ‘doubly magic’ nuclei. Both 27 O and 28 O were found to exist as narrow, low-lying resonances and their decay energies are compared here to the results of sophisticated theoretical modelling, including a large-scale shell-model calculation and a newly developed statistical approach. In both cases, the underlying nuclear interactions were derived from effective field theories of quantum chromodynamics. Finally, it is shown that the cross-section for the production of 28 O from a 29 F beam is consistent with it not exhibiting a closed N = 20 shell structure.
Production of antihydrogen atoms by 6 keV antiprotons through a positronium cloud
The European Physical Journal C · 2023-11-06 · 13 citations
articleOpen accessAbstract We report on the first production of an antihydrogen beam by charge exchange of 6.1 keV antiprotons with a cloud of positronium in the GBAR experiment at CERN. The 100 keV antiproton beam delivered by the AD/ELENA facility was further decelerated with a pulsed drift tube. A 9 MeV electron beam from a linear accelerator produced a low energy positron beam. The positrons were accumulated in a set of two Penning–Malmberg traps. The positronium target cloud resulted from the conversion of the positrons extracted from the traps. The antiproton beam was steered onto this positronium cloud to produce the antiatoms. We observe an excess over background indicating antihydrogen production with a significance of 3–4 standard deviations.
Publisher Correction: First observation of 28O
Nature · 2023-11-07 · 4 citations
erratumOpen access<br/>
International Journal of Gynecological Cancer · 2021-11-01
articleOpen access
Recent grants
NIH · $1.1M · 1990
NIH · $165k · 1988
Frequent coauthors
- 22 shared
N. L. Achouri
Normandie Université
- 22 shared
J. Gibelin
Centre National de la Recherche Scientifique
- 22 shared
N. A. Orr
Laboratoire de Physique Corpusculaire de Caen
- 22 shared
F. Delaunay
École Nationale Supérieure d'Ingénieurs de Caen
- 20 shared
F. M. Marqués
- 19 shared
Mintsai Liu
- 16 shared
Margaret R. Byers
University of Washington
- 16 shared
Karin J. Heyeraas
Education
D.D.S., Ph.D., Endodontics
Columbia University
Awards & honors
- Leonard Davis Institute Summer Research Fellowship
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