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Nova · Professor Researcher · re-ranking top 20…
Edward James

Edward James

· Ahearn

Brown University · Comparative Literature

Active 2015–2021

h-index6
Citations145
Papers106 last 5y
Funding—
Faculty page
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Research topics

  • Genetics
  • Biology
  • Cell biology
  • Neuroscience

Selected publications

  • Role of matrix metalloproteinase-9 in neurodevelopmental deficits and experience-dependent plasticity in Xenopus laevis

    eLife · 2021 · 20 citations

    • Neuroscience
    • Biology
    • Cell biology

    tadpoles, VPA exposure results in excess local synaptic connectivity, disrupted social behavior and increased seizure susceptibility. We found that overexpressing MMP-9 in the brain copies effects of VPA on synaptic connectivity, and blocking MMP-9 activity pharmacologically or genetically reverses effects of VPA on physiology and behavior. We further show that during normal neurodevelopment MMP-9 levels are tightly regulated by neuronal activity and required for structural plasticity. These studies show a critical role for MMP-9 in both normal and abnormal development.

    PublisherDOI

Frequent coauthors

  • Carlos D. Aizenman

    John Brown University

    14 shared

  • Jenn J. Park

    American Cleft Palate-Craniofacial Association

    8 shared

  • Andrea Berghella

    Thomas Jefferson University

    8 shared

  • Sayali V. Gore

    Providence College

    8 shared

  • Hollis T. Cline

    Scripps Research Institute

    6 shared

  • Mashfiq Hasan

    Brown University

    5 shared

  • Torrey L.S. Truszkowski

    Brown University

    5 shared

  • Adrian C. Thompson

    John Brown University

    4 shared
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