
Edward James
· AhearnBrown University · Comparative Literature
Active 2015–2021
Research topics
- Genetics
- Biology
- Cell biology
- Neuroscience
Selected publications
eLife · 2021 · 20 citations
- Neuroscience
- Biology
- Cell biology
tadpoles, VPA exposure results in excess local synaptic connectivity, disrupted social behavior and increased seizure susceptibility. We found that overexpressing MMP-9 in the brain copies effects of VPA on synaptic connectivity, and blocking MMP-9 activity pharmacologically or genetically reverses effects of VPA on physiology and behavior. We further show that during normal neurodevelopment MMP-9 levels are tightly regulated by neuronal activity and required for structural plasticity. These studies show a critical role for MMP-9 in both normal and abnormal development.
Frequent coauthors
- 14 shared
Carlos D. Aizenman
John Brown University
- 8 shared
Jenn J. Park
American Cleft Palate-Craniofacial Association
- 8 shared
Andrea Berghella
Thomas Jefferson University
- 8 shared
Sayali V. Gore
Providence College
- 6 shared
Hollis T. Cline
Scripps Research Institute
- 5 shared
Mashfiq Hasan
Brown University
- 5 shared
Torrey L.S. Truszkowski
Brown University
- 4 shared
Adrian C. Thompson
John Brown University
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