Brannon Cho
· CellistVerifiedNorthwestern University · Strings
Active 1994–2024
Research topics
- Cell biology
- Genetics
- Biology
- Chemistry
- Cancer research
Selected publications
SF3B1 homeostasis is critical for survival and therapeutic response in T cell leukemia
Science Advances · 2022 · 59 citations
- Cancer research
- Biology
- Cell biology
, and impaired DNA damage response. We also identified that SF3B1 inhibition leads to a general decrease in R-loop formation. We further demonstrate that clinically used SF3B1 inhibitors synergize with CHEK2 inhibitors and chemotherapeutic drugs to block leukemia growth. Our study provides the proof of principle for posttranslational regulation of splicing components and associated roles and therapeutic implications for the U2 complex in T cell leukemia.
Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia
Cancer Discovery · 2020 · 100 citations
- Biology
- Cell biology
- Genetics
.
Frequent coauthors
- 50 shared
Young Ah Goo
James S. McDonnell Foundation
- 20 shared
M. Luisa Iruela‐Arispe
Northwestern University
- 20 shared
Robert Damoiseaux
- 19 shared
Feiyang Ma
University of California, Los Angeles
- 19 shared
Georg Hilfenhaus
Charité - Universitätsmedizin Berlin
- 19 shared
Vanessa M. Freitas
Universidade de São Paulo
- 19 shared
Divya P. Prajapati
University of California, San Diego
- 19 shared
Jonathan Freshman
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