About

Helen Bateup is an Associate Professor of Molecular Therapeutics at the University of California, Berkeley. She is part of the Department of Molecular and Cell Biology and conducts research in the field of molecular therapeutics. Her laboratory is located at 291 Weill Hall, Berkeley, CA, and she can be contacted via email at bateup@berkeley.edu or by phone at (510) 664-4009. Her research focuses on understanding molecular mechanisms relevant to therapeutic development, contributing to advancements in molecular and cell biology.

Research topics

• Biology
• Neuroscience
• Computer Science
• Computational biology
• Virology
• Genetics
• Geography
• Cell biology
• Cartography
• Zoology
• Immunology
• Medicine
• Anatomy
• Environmental health

Selected publications

• A nomenclature consensus for nervous system organoids and assembloids

  Nature · 2022 · 283 citations

  • Computer Science
  • Computational biology
  • Biology
  DOI

• A multimodal cell census and atlas of the mammalian primary motor cortex

  Nature · 2021 · 564 citations

  • Neuroscience
  • Biology
  • Computational biology

  . First, our study reveals a unified molecular genetic landscape of cortical cell types that integrates their transcriptome, open chromatin and DNA methylation maps. Second, cross-species analysis achieves a consensus taxonomy of transcriptomic types and their hierarchical organization that is conserved from mouse to marmoset and human. Third, in situ single-cell transcriptomics provides a spatially resolved cell-type atlas of the motor cortex. Fourth, cross-modal analysis provides compelling evidence for the transcriptomic, epigenomic and gene regulatory basis of neuronal phenotypes such as their physiological and anatomical properties, demonstrating the biological validity and genomic underpinning of neuron types. We further present an extensive genetic toolset for targeting glutamatergic neuron types towards linking their molecular and developmental identity to their circuit function. Together, our results establish a unifying and mechanistic framework of neuronal cell-type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties.

  DOI

• Interferon-independent STING signaling promotes resistance to HSV-1 in vivo

  Nature Communications · 2020 · 171 citations

  • Biology
  • Cell biology
  • Virology

  The Stimulator of Interferon Genes (STING) pathway initiates potent immune responses upon recognition of DNA. To initiate signaling, serine 365 (S365) in the C-terminal tail (CTT) of STING is phosphorylated, leading to induction of type I interferons (IFNs). Additionally, evolutionary conserved responses such as autophagy also occur downstream of STING, but their relative importance during in vivo infections remains unclear. Here we report that mice harboring a serine 365-to-alanine (S365A) mutation in STING are unexpectedly resistant to Herpes Simplex Virus (HSV)-1, despite lacking STING-induced type I IFN responses. By contrast, resistance to HSV-1 is abolished in mice lacking the STING CTT, suggesting that the STING CTT initiates protective responses against HSV-1, independently of type I IFNs. Interestingly, we find that STING-induced autophagy is a CTT- and TBK1-dependent but IRF3-independent process that is conserved in the STING S365A mice. Thus, interferon-independent functions of STING mediate STING-dependent antiviral responses in vivo.

  DOI

Recent grants

• The impact of Tsc-mTOR signaling on basal ganglia function

  NIH · $1.3M · 2019–2024

• The impact of Tsc-mTOR signaling on cells and circuits in the basal ganglia

  NIH · $383k · 2017–2019

• Elucidating the origins of cortical tuber cells using human brain organoid models of TSC

  NIH · $3.5M · 2016–2026

Frequent coauthors

• Dirk Hockemeyer

  University of California, Berkeley

  83 shared

• Hanqin Li

  Research Network (United States)

  38 shared

• Donald C. Rio

  Research Network (United States)

  32 shared

• Khaja Syed

  Research Network (United States)

  29 shared

• Oriol Busquets

  Albert Einstein College of Medicine

  29 shared

• Frank Soldner

  Research Network (United States)

  29 shared

• Luke A. Gilbert

  University of California, San Francisco

  26 shared

• Yogendra Verma

  University of California, Berkeley

  23 shared

Similar researchers at University of California, Berkeley

• Peidong Yangh-262
• Jennifer A. Doudnah-230
• Jeffrey R. Longh-189
• John F. Hartwigh-180
• Rasmus Nielsenh-180