About

Bachir Alobeid, MD, is a Professor of Pathology & Cell Biology at Columbia University Irving Medical Center. He specializes in hematopathology, with expertise in a wide range of hematologic malignancies including acute leukemia, chronic leukemia, lymphomas, and pediatric leukemias. Dr. Alobeid serves as the Director of the Hematopathology Service at NewYork-Presbyterian / Columbia University Irving Medical Center. He completed his medical education at Damascus University School of Medicine in Syria, followed by internship and residency at Brooklyn Hospital Center. His fellowship training was conducted at Roswell Park Comprehensive Cancer Institute. Dr. Alobeid is a full member of the Society for Hematopathology, where he has held leadership roles including Chairperson of the Education Committee and Chairperson of the Membership Committee. He is also involved with the Association of Pathology Chairs and the Columbia University Vagelos College of Physicians and Surgeons Academy of Clinical Excellence. His research and clinical work focus on hematopathology, and he has been recognized with awards such as the Pickren Pathology Award and faculty teaching awards from Columbia University. Dr. Alobeid is actively engaged in education, research, and professional service within the field of pathology.

Research topics

• Biology
• Cancer research
• Genetics
• Engineering
• Engineering ethics
• Pathology
• Psychology
• Medicine
• Medical education
• Immunology

Selected publications

• POORER SURVIVAL IN PEDIATRIC POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDER (PTLD) DIAGNOSED DURING ADOLESCENCE

  Leukemia Research · 2025-09-01

  article
  PublisherDOI

• Spectrum of Kidney Biopsy Findings in a Patient With Primary Myelofibrosis

  Kidney International Reports · 2025-10-25

  articleOpen access
  PublisherDOI

• β-Actin G342D as a Cause of NK Cell Deficiency Impairing Lytic Synapse Termination

  The Journal of Immunology · 2024-02-05 · 8 citations

  articleOpen access

  NK cell deficiency (NKD) occurs when an individual's major clinical immunodeficiency derives from abnormal NK cells and is associated with several genetic etiologies. Three categories of β-actin-related diseases with over 60 ACTB (β-actin) variants have previously been identified, none with a distinct NK cell phenotype. An individual with mild developmental delay, macrothrombocytopenia, and susceptibility to infections, molluscum contagiosum virus, and EBV-associated lymphoma had functional NKD for over a decade. A de novo ACTB variant encoding G342D β-actin was identified and was consistent with the individual's developmental and platelet phenotype. This novel variant also was found to have direct impact in NK cells because its expression in the human NK cell line YTS (YTS-NKD) caused increased cell spreading in lytic immune synapses created on activating surfaces. YTS-NKD cells were able to degranulate and perform cytotoxicity, but they demonstrated defective serial killing because of prolonged conjugation to the killed target cell and thus were effectively unable to terminate lytic synapses. G342D β-actin results in a novel, to our knowledge, mechanism of functional NKD via increased synaptic spreading and defective lytic synapse termination with resulting impaired serial killing, leading to overall reductions in NK cell cytotoxicity.

  PublisherOA PDFDOI

• Normoblastemia in COVID-19 patients is associated with more severe disease and adverse outcome.

  PubMed · 2023-01-01

  articleOpen accessSenior author

  OBJECTIVES: The clinical, pathological, and laboratory correlates of normoblastemia in COVID-19 patients have not been adequately explored. We sought to assess the frequency of normoblastemia in COVID-19, its association with other markers of disease, as well as other clinical outcomes. METHODS: All COVID-19 patients seen at our institution with at least one automated complete blood count (aCBC) evaluation from March to May 2020 were included in this retrospective cohort analysis. Results of aCBC and tests for markers of the acute phase response performed within 5 days before the first COVID-19 positive test and 14 days after the last positive test were reviewed. We also evaluated histologic features of the reticuloendothelial system of COVID-19 decedents. RESULTS: quartile) WBC (15.7 (11.2, 23.1) u/L vs. 8.3 (6.2, 11.5) u/L), absolute neutrophil count (7.0 (5.1, 10.1) u/L vs. 5.1 (3.7, 7.3) u/L), immature granulocyte percentage (0.8 (0.5, 1.3)% vs. 0.5 (0.3, 0.8)%), ESR (76.0 (60.5, 100.0) mm/hr vs. 66.0 (45.0, 87.0) mm/hr), ferritin (1404.5 (645.0, 2871.0) ng/mL vs. 672.7 (313.4, 1348.0) ng/mL), INR (1.4 (1.2, 1.7) vs. 1.2 (1.1, 1.3)), D-dimer (8.2 (2.8, 20.0) ug/mL FEU vs. 1.5 (0.8, 3.7) µg/mL FEU), and IL-6 (216.6 (77.7, 315.0) pg/mL vs. 54.3 (23.2, 127.8) pg/mL) levels, and lower hemoglobin (12.5 (10.7, 14.2) g/dL vs. 13.2 (11.8, 14.6) g/dL) and absolute lymphocyte count (1.0 (0.7, 1.3) u/L vs. 1.1 (0.8, 1.5) u/L). The incidence of intubation and ventilation support (61.3% (65/106) vs. 10.5% (31/263)) and mortality rates (37.9%, 271/715 vs. 11.8%, 210/1786), were higher in normoblastemic patients. Multivariable logistic regression revealed normoblastemia to be an independent predictive biomarker of short-term mortality in COVID-19. CONCLUSION: Normoblastemia in COVID-19 is associated with markers of severe disease, extramedullary erythropoiesis, and adverse clinical outcome.

  PublisherOA PDF

• Clinical Utility and Reimbursement of Next-Generation Sequencing–Based Testing for Myeloid Malignancies

  Journal of Molecular Diagnostics · 2023-11-20 · 4 citations

  articleOpen access
  PublisherOA PDFDOI

• <i>IRF4/DUSP22</i>-positive anaplastic large cell lymphoma arising in the setting of chronic olecranon bursitis

  Blood · 2023-06-08 · 1 citations

  articleOpen accessSenior author
  PublisherOA PDFDOI

• Utility of Flow Cytometry Analysis in the Detection of Nonhematologic Neoplasms

  Clinics in Laboratory Medicine · 2023-06-10

  reviewSenior authorCorresponding
  PublisherDOI

• Whole exome sequencing of primary cutaneous CD4+ small/medium T‐cell lymphoproliferative disorders

  Hematological Oncology · 2023-04-03 · 3 citations

  letterOpen access

  The peer review history for this article is available at https://www.webofscience.com/api/gateway/wos/peer-review/10.1002/hon.3133. Data are available upon requests to the corresponding author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

  PublisherOA PDFDOI

• Incidental intra‐adrenal splenule

  Clinical Case Reports · 2021-07-01 · 3 citations

  articleOpen accessSenior author

  Splenules can be found in the adrenals and should be considered in the differential diagnosis of adrenal incidentalomas.

  PublisherDOI

• Composite mantle cell lymphoma and small lymphocytic lymphoma in a lymph node

  Blood · 2021-01-14 · 3 citations

  articleOpen accessSenior author
  PublisherOA PDFDOI

Frequent coauthors

• Govind Bhagat

  Columbia University

  253 shared

• Vundavalli V. Murty

  Herbert Irving Comprehensive Cancer Center

  113 shared

• Mahesh Mansukhani

  Columbia University Irving Medical Center

  67 shared

• Deborah W. Sevilla

  40 shared

• Daniela Hoehn

  Genmab (United States)

  36 shared

• Giorgio Cattoretti

  University of Milano-Bicocca

  35 shared

• Subhadra V. Nandula

  35 shared

• Adriana I. Colovai

  31 shared

Awards & honors

• Pickren Pathology Award: Presented by the Pathology Faculty…
• The Dr. Joseph G. Fink laboratory Medicine Faculty Teaching…
• The Dr. Karl Perzin Anatomic Pathology Faculty Teaching Awar…