Arnold J. Levine

About

Arnold J. Levine is the Harry C. Wiess Professor in the Life Sciences, Emeritus, and a Professor of Molecular Biology, Emeritus, at Princeton University. His research area includes Cell Biology, Development & Cancer. He is associated with the Department of Molecular Biology at Princeton, which features a broad range of research labs and facilities dedicated to molecular biology, biophysics, structural biology, and related fields. His work and contributions are recognized within the department and the broader scientific community, emphasizing his longstanding involvement in advancing understanding in molecular biology and related disciplines.

Research topics

• Biology
• Evolutionary biology
• Genetics

Selected publications

• p53: 800 million years of evolution and 40 years of discovery

  Nature reviews. Cancer · 2020-05-13 · 838 citations

  review1st authorCorresponding
  PublisherDOI

• Supplementary File S2 from Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator

  2025-06-03

  preprintOpen access

  <p>p53 pathway profiling analysis in NUGC-3 KO_p53i cells induced with doxycycline (50 ng/ml) vs. PBS control (12.5 h).</p>

  PublisherDOI

• Supplementary File S1 from Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator

  2025-06-03

  preprintOpen access

  <p>p53 pathway profiling analysis in NUGC-3 cells treated by PC14586 (5 µM) vs. DMSO control (16 h).</p>

  PublisherDOI

• Supplementary File S4 from Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator

  2025-06-03

  preprintOpen access

  <p>p53 pathway profiling analysis in NUGC-3 cells treated by PC14586 (5 µM) vs. DMSO control (5 h).</p>

  PublisherDOI

• Figure 1 from Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator

  2025-06-03

  preprintOpen access

  <p>Functional characterization of p53-Y220C reactivator compounds and restoration of WT p53 function in cells. <b>A,</b> Structure of p53 reactivators and biochemical properties. The concentration of the test compound required to increase Y220C-DBD binding to the DNA from a consensus p53 response element by 1.5-fold (SC<sub>150</sub>) was measured by the TR-FRET assay; the binding constant (Kd) was determined by surface plasmon resonance (SPR), and the structural st…

  PublisherDOI

Recent grants

• Roles and Regulation of wild-type and mutant forms of p53

  NIH · $3.8M · 2000–2023

• NIH Grant T32CA009528

  NIH · $11.9M · 2012

• NIH Grant R01CA038757

  NIH · $1.0M · 1989

Frequent coauthors

• Alexei Vázquez

  170 shared

• Wenwei Hu

  The First People's Hospital of Changzhou

  165 shared

• Gareth L. Bond

  152 shared

• Zhaohui Feng

  Rutgers Cancer Institute of New Jersey

  115 shared

• Elisabeth E. Bond

  109 shared

• Gyan Bhanot

  Rutgers, The State University of New Jersey

  101 shared

• Lukasz F. Grochola

  Kantonsspital Winterthur

  92 shared

• Helge Täubert

  Universitätsklinikum Erlangen

  84 shared

Similar researchers at Princeton University

• Thomas E. Shenkh-136
• Michael Levineh-131
• Bonnie L. Basslerh-130