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Dr. Sarah Chen
Stanford · NLP & interpretability
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Fairness + NLP projects overlap with her recent work.
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Ask how her lab is extending interpretability methods into fairness audits for real-world AI systems.
Dr. Anneli R. Bowen is an Associate Professor of Dermatology at the University of Utah. She has a subspecialization in dermatopathology and a clinical interest in general dermatology. After earning her Bachelor of Science degree at MIT, she attended the University of Michigan Medical School. She completed a dermatology residency at the University of Utah and a dermatopathology fellowship at the University of California, San Francisco. Dr. Bowen has served on the editorial board for the Journal of Cutaneous Pathology and is a reviewer for several dermatopathology and dermatology journals. She is highly interested in mentoring residents and junior faculty, chairing the Peer Review Committee for the American Society of Dermatopathology and the Clinical Competency Committee in the Department of Dermatology. Her research and scholarly work include over 35 scientific papers and several book chapters, with a focus on melanoma, specifically lentigo maligna, and the histopathology of inflammatory and neoplastic skin diseases.
<sec> <title>BACKGROUND</title> Maldistribution of providers, variable insurance coverage, and underrepresentation within dermatology all affect patient access to dermatology services. Few studies have evaluated institutional models for addressing these pervasive gaps. </sec> <sec> <title>OBJECTIVE</title> To evaluate one academic institution’s efforts to comprehensively expand access to dermatology services. </sec> <sec> <title>METHODS</title> A retrospective analysis was performed using data from the University of Utah Health (UUH) Dermatology’s outreach clinics compared with general dermatology ambulatory (GDA) clinics in Salt Lake City over three years. Descriptive statistics were reported for patient demographics, insurance, and diagnosis. Statistical methods assessed differences between clinic types. Outreach clinics were categorized by delivery method: rural “fly-in” clinics, live video teledermatology (rural and incarcerated), free clinics in urban areas, and asynchronous eConsults (store-and-forward teledermatology). </sec> <sec> <title>RESULTS</title> Outreach clinics served 2,283 distinct patients (3,471 encounters). The general dermatology clinics at the University of Utah yielded 207,493 patients (1,141,280 encounters). Outreach clinics overall served a more diverse, younger, and Medicaid-insured patient population than general ambulatory clinics, with a higher prevalence of inflammatory/autoimmune conditions. eConsult and free clinic encounters more commonly served patients under 65 years of age, and eConsult encounters, specifically, served a more racially/ethnically diverse patient population as compared to UUH GDA clinic encounters. </sec> <sec> <title>CONCLUSIONS</title> This study confirms that UUH Dermatology’s efforts to enhance healthcare access are effectively reaching targeted underserved patient populations. </sec> <sec> <title>CLINICALTRIAL</title> N/A </sec>
OBJECTIVE: Retrospective cohort study assessing real-world use patterns and test properties of labial salivary gland biopsy (LSGBx) for diagnosing Sjögren's disease (SjD). METHODS: We retrieved 89 LSGBx samples from our dermatopathology archive and obtained 23 cadaveric LSGBx samples without known autoimmune diseases for control. SjD cases included 15 seropositive Sjögren's disease (spSjD), 34 seronegative Sjögren's disease (snSjD), and 40 not SjD. All slides were de-identified and presented in random order to a blinded dermatopathologist and oral pathologist to review and score all samples according to established criteria. Patient demographics and clinical information were obtained via chart review. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of LSGBx were calculated, and odds of a SjD diagnosis after a positive LSGBx was assessed with logistic regression. RESULTS: LSGBx supported SjD in 73.3% of spSjD, 73.5% of snSjD, and 55.0% of notSjD cases, and 21.7% of cadaveric specimens. Sensitivity for SjD (spSjD + snSjD) was 73.5%, specificity was 45.0%, PPV was 62.1%, and NPV was 58.1%. A positive LSGBx increased the odds of SjD (OR=2.27, 95% CI: 0.93-5.51). The odds were similar and non-significant for spSjD and snSjD. Cadaveric specimens had lower LSGBx positivity rates compared to notSjD cases (OR=0.24, 95% CI: 0.07-0.77). Objective measures of eye dryness (14/89 cases) or oral dryness (0/89) were infrequently assessed. CONCLUSION: The predictive value of LSGBx for SjD is limited. The lack of objective clinical data in this cohort suggests that LSGBx is often heavily weighted for diagnosis, but these data question that approach.
Annals of Internal Medicine Clinical Cases · 2025-05-01
articleOpen access
Lung cancer remains a leading cause of malignancy-related mortality among adults worldwide. Metastasis of primary lung adenocarcinoma to the skin is rare, morphologically heterogeneous, and may affect any body site. Cutaneous metastases portend a poor prognosis with worsened survival rates. The diagnosis is typically established via histopathology with supportive immunohistochemistry. Treatment varies based on the extent of involvement.
BACKGROUND: This case report describes a 10-year-old male with a history of kidney transplantation who developed trichodysplasia spinulosa (TS), a rare skin disorder associated with immunosuppression. METHODS: The patient's condition, characterized by follicular papules and keratinous spines primarily on the face, was managed by a multidisciplinary team. RESULTS: Treatment involved reducing immunosuppression and administering topical cidofovir alongside oral leflunomide, leading to significant clinical improvement over several months. CONCLUSIONS: This case adds to the literature of TS management and highlights the importance of multidisciplinary care as well as the challenges of treatment accessibility due to insurance limitations.
Melanoma is the most aggressive form of common skin cancer and recurrence, while rare, typically presents as pigmented papules or nodules near the primary site. Here, we describe a case of a woman with stage IIIC melanoma undergoing intralesional talimogene laherparepvec (T-VEC) therapy who developed a spreading erythematous rash on her left leg, accompanied by fatigue and leg swelling. Skin biopsy revealed recurrent melanoma, with SOX10 and Melan-A positivity, and imaging showed features concerning for multifocal disease recurrence in the left popliteal fossa. This case highlights an unusual presentation of melanoma recurrence and underscores the importance of biopsy in -evaluating new skin findings in patients with a history of melanoma.