Angela M DeMichele
University of Pennsylvania · Rehabilitation Medicine
Active 1991–2026
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About
Angela M DeMichele, MD, MSCE, FASCO, is the Mariann T. and Robert J. MacDonald Professor in Breast Cancer Care Excellence at the University of Pennsylvania. She is a Senior Scholar at the Center for Clinical Epidemiology and Biostatistics and serves as Co-Leader of the Breast Cancer Program at the Abramson Cancer Center. Additionally, she is Co-Director of the 2-PREVENT Breast Cancer Translational Center of Excellence and Director of Clinical/Translational Research in Solid Oncology within the Division of Hematology/Oncology. Her research expertise encompasses breast cancer, biomarkers, clinical trials, pharmacogenetics, cytokines, host immunogenetics, cancer survivorship, and molecular epidemiology. Her clinical focus includes breast cancer, neoadjuvant therapy, menopausal symptoms related to cancer, and cancer survivorship. Dr. DeMichele has contributed to numerous studies and publications in these areas, advancing understanding and treatment of breast cancer.
Research topics
- Internal medicine
- Medicine
- Oncology
- Gynecology
- Immunology
- Cardiology
- Biology
Selected publications
JAMA Oncology · 2020 · 695 citations
Importance: Approximately 25% of patients with early-stage breast cancer who receive (neo)adjuvant chemotherapy experience a recurrence within 5 years. Improvements in therapy are greatly needed. Objective: To determine if pembrolizumab plus neoadjuvant chemotherapy (NACT) in early-stage breast cancer is likely to be successful in a 300-patient, confirmatory randomized phase 3 neoadjuvant clinical trial. Design, Setting, and Participants: The I-SPY2 study is an ongoing open-label, multicenter, a…
CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer
Nature Medicine · 2021 · 512 citations
Adjuvant Palbociclib for Early Breast Cancer: The PALLAS Trial Results (ABCSG-42/AFT-05/BIG-14-03)
Journal of Clinical Oncology · 2021 · 230 citations
PURPOSE: Palbociclib is a cyclin-dependent kinase 4 and 6 inhibitor approved for advanced breast cancer. In the adjuvant setting, the potential value of adding palbociclib to endocrine therapy for hormone receptor-positive breast cancer has not been confirmed. PATIENTS AND METHODS: In the prospective, randomized, phase III PALLAS trial, patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative early breast cancer were randomly assigned to receive 2 years of palbo…
JAMA Oncology · 2020 · 220 citations
Importance: Pathologic complete response (pCR) is a known prognostic biomarker for long-term outcomes. The I-SPY2 trial evaluated if the strength of this clinical association persists in the context of a phase 2 neoadjuvant platform trial. Objective: To evaluate the association of pCR with event-free survival (EFS) and pCR with distant recurrence-free survival (DRFS) in subpopulations of women with high-risk operable breast cancer treated with standard therapy or one of several novel agents. Des…
Journal of the American Heart Association · 2020 · 160 citations
Background We examined the longitudinal associations between changes in cardiovascular biomarkers and cancer therapy-related cardiac dysfunction (CTRCD) in patients with breast cancer treated with cardotoxic cancer therapy. Methods and Results Repeated measures of high-sensitivity cardiac troponin T (hs-cTnT), NT-proBNP (N-terminal pro-B-type natriuretic peptide), myeloperoxidase, placental growth factor, and growth differentiation factor 15 were assessed longitudinally in a prospective cohort o…
Recent grants
NIH · $36.3M · 2017–2028
Secondary Prevention through Surveillance and Intervention
NIH · $3.2M · 2016–2022
Radiobiology and Imaging Program
NIH · $93.0M · 1997–2027
Frequent coauthors
- 1422 shared
Christina Yau
University of California, San Francisco
- 1290 shared
Douglas Yee
Masonic Cancer Center
- 956 shared
AJ Chien
Gemini Computers (United States)
- 945 shared
LJ Esserman
UCSF Helen Diller Family Comprehensive Cancer Center
- 938 shared
Rita Nanda
University of Chicago
- 915 shared
Debu Tripathy
The University of Texas MD Anderson Cancer Center
- 865 shared
MC Liu
- 850 shared
Claudine Isaacs
Labs
Angela M DeMichele LabPI
Awards & honors
- Mariann T. and Robert J. MacDonald Professor in Breast Cance…
- Senior Scholar, Center for Clinical Epidemiology and Biostat…
- Co-Leader, Breast Cancer Program, Abramson Cancer Center, Un…
- Co-Director, 2-PREVENT Breast Cancer Translational Center of…
- Director of Clinical/Translational Research in Solid Oncolog…
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