Andrew P. Goodwin

About

Andrew P. Goodwin is a Professor and Principal Investigator at the University of Colorado Boulder. He hails from New York and received his B.A. in Chemistry from Columbia University. He then pursued his Ph.D. in Chemistry at the University of California, Berkeley. Following his doctoral studies, he completed postdoctoral fellowships at Stanford University and the University of California, San Diego. In 2012, he began his academic career as an Assistant Professor at the University of Colorado Boulder. Outside of his professional work, Andrew enjoys reading and running, though not simultaneously.

Research topics

• Chemistry
• Materials science
• Nanotechnology
• Organic chemistry
• Biophysics
• Cell biology
• Mechanical engineering
• Computational biology
• Biology
• Biochemistry

Selected publications

• Nongenetic Bioconjugation Strategies for Modifying Cell Membranes and Membrane Proteins: A Review

  Bioconjugate Chemistry · 2020 · 34 citations

  Senior authorCorresponding

  . Another approach is to instead attach exogenous functional groups to the cell membrane without changing the genetic nature of the cell. This review focuses on more recent approaches of nongenetic methods of cell surface modification through metabolic pathways, anchorage by hydrophobic interactions, and chemical conjugation. Benefits and drawbacks of each approach are considered, followed by a discussion of potential applications for nongenetic cell surface modification and an outlook on the fu…

  PublisherOA PDFDOI

• The Effect of Container Surface Passivation on Aggregation of Intravenous Immunoglobulin Induced by Mechanical Shock

  Biotechnology Journal · 2020 · 19 citations

  Senior authorCorresponding

  Abstract Aggregation of therapeutic proteins can result from a number of stress conditions encountered during their manufacture, transportation, and storage. This work shows the effects of two interrelated sources of protein aggregation: the chemistry and structure of the surface of the container in which the protein is stored, and mechanical shocks that may result from handling of the formulation. How different mechanical stress conditions (dropping, tumbling, and agitation) and container surfa…

  PublisherOA PDFDOI

• Enzyme Prodrug Therapy with Photo-Cross-Linkable Anti-EGFR Affibodies Conjugated to Upconverting Nanoparticles

  ACS Nano · 2022-09-21 · 17 citations

  articleOpen accessSenior authorCorresponding

  In this work, we demonstrate that a photo-cross-linkable conjugate of upconverting nanoparticles and cytosine deaminase can catalyze prodrug conversion specifically at tumor sites in vivo. Non-covalent association of proteins and peptides with cellular surfaces leads to receptor-mediated endocytosis and catabolic degradation. Recently, we showed that covalent attachment of proteins such as affibodies to cell receptors yields extended expression on cell surfaces with preservation of protein funct…

  PublisherOA PDFDOI

• Combination of Chemical and Mechanical Tumor Immunomodulation Using Cavitating Mesoporous Silica Nanoparticles

  ACS Applied Nano Materials · 2024-08-06 · 15 citations

  articleOpen accessCorresponding

  Combinatorial methods to repolarize tumor-associated macrophages from anti-inflammatory to pro-inflammatory phenotypes offers a promising route for cancer immunotherapy. However, most studies examine biochemical combinations alone. Therefore, we studied simultaneous chemical and mechanical stimuli as orthogonal cues for enhanced immunomodulation. We engineered the surfaces of hydrophobically functionalized mesoporous silica nanoparticles (F108-hMSNs) to encapsulate the immunomodulator resiquimod…

  PublisherOA PDFDOI

• Investigating Protein–Nanocrystal Interactions for Photodriven Activity

  ACS Applied Bio Materials · 2020 · 12 citations

  production was observed from MoFeP and C-MoFeP, respectively. At last, to test the effect of both charge and covalent tethering, positively charged cysteamine/azide CdS NRs were reacted with DBCO-modified C-MoFeP, which showed little improvement over native C-MoFeP alone under irradiation. These results show the importance of both electrostatic associations between the NR and protein and covalently tethering the protein to the semiconductor surface for enhanced electron transfer and photodriven…

  PublisherDOI

Recent grants

• Controllable 2- and 3D Assembly of Mechanically Robust Skin Tissue Via Long Term Expression of DNA on Cell Membranes

  NIH · $347k · 2021–2022

• Design of Nanostructures for Light-Mediated Propulsion for Molecular Delivery into Tissue

  NSF · $569k · 2020–2024

• Hollow Silica-Polymer Nanocomposites for Stimulus-Responsive Ultrasound Contrast

  NIH · $154k · 2016–2018

Frequent coauthors

• N. Jennifer

  University of Colorado Boulder

  47 shared

• Rajarshi Chattaraj

  University of Pennsylvania

  17 shared

• Adem Yıldırım

  Oregon Health & Science University

  17 shared

• Shambojit Roy

  Twin Cities Orthopedics

  14 shared

• Zhuang Liu

  University of Louisville

  11 shared

• Jean M. J. Fréchet

  11 shared

• Wounjhang Park

  10 shared

• Alexander W. Harris

  Monash University

  10 shared

Labs

• Goodwin Research GroupPI

  Not provided

Education

• B.A.

  Columbia University

  2002

• Ph.D.

  University of California, Berkeley

  2007

Awards & honors

• NAE Frontiers of Engineering, US Meeting Participant (2016)
• NIH Director’s New Innovator Award (2014-2019)
• NIH K99/R00 Pathway to Independence Award in Cancer Nanotech…
• DOD Breast Cancer Postdoctoral Fellowship Award (2010-2013)
• AACR Scholar-in-Training Award (2011)

Similar researchers at University of Colorado Boulder

• Michael D. McGeheeh-147
• Christopher N. Bowmanh-114
• Ryan Haywardh-64