Andrew Nobel

About

Andrew B. Nobel is the Paul Ziff Distinguished Professor in the Department of Statistics and Operations Research at the University of North Carolina at Chapel Hill. His professional contact details include an office in 308 Hanes Building, with telephone and fax numbers provided for direct communication. Professor Nobel's research interests encompass several advanced areas in statistics and data science, including Machine Learning and Data Mining, Statistical Genomics, Analysis of Networks, and Inference from Dynamical Systems. In addition to his primary academic appointment, he holds significant roles as a Full Member of the UNC Lineberger Comprehensive Cancer Center and as a Member of the UNC Computational Genomics Program. These appointments highlight his interdisciplinary engagement and contributions to computational and genomic research within the university.

Research topics

• Biology
• Genetics
• Computational biology
• Medicine
• Cell biology
• Evolutionary biology
• Pathology

Selected publications

• The GTEx Consortium atlas of genetic regulatory effects across human tissues

  Science · 2020 · 5682 citations

  The Genotype-Tissue Expression (GTEx) project was established to characterize genetic effects on the transcriptome across human tissues and to link these regulatory mechanisms to trait and disease associations. Here, we present analyses of the version 8 data, examining 15,201 RNA-sequencing samples from 49 tissues of 838 postmortem donors. We comprehensively characterize genetic associations for gene expression and splicing in cis and trans, showing that regulatory associations are found for alm…

  PublisherOA PDFDOI

• The impact of sex on gene expression across human tissues

  Science · 2020 · 703 citations

  Many complex human phenotypes exhibit sex-differentiated characteristics. However, the molecular mechanisms underlying these differences remain largely unknown. We generated a catalog of sex differences in gene expression and in the genetic regulation of gene expression across 44 human tissue sources surveyed by the Genotype-Tissue Expression project (GTEx, v8 release). We demonstrate that sex influences gene expression levels and cellular composition of tissue samples across the human body. A t…

  DOI

• Determinants of telomere length across human tissues

  Science · 2020 · 486 citations

  Telomere shortening is a hallmark of aging. Telomere length (TL) in blood cells has been studied extensively as a biomarker of human aging and disease; however, little is known regarding variability in TL in nonblood, disease-relevant tissue types. Here, we characterize variability in TLs from 6391 tissue samples, representing >20 tissue types and 952 individuals from the Genotype-Tissue Expression (GTEx) project. We describe differences across tissue types, positive correlation among tissue typ…

  DOI

• Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease

  Cell · 2021 · 212 citations

  PublisherOA PDFDOI

• Transcriptomic signatures across human tissues identify functional rare genetic variation

  Science · 2020 · 162 citations

  Rare genetic variants are abundant across the human genome, and identifying their function and phenotypic impact is a major challenge. Measuring aberrant gene expression has aided in identifying functional, large-effect rare variants (RVs). Here, we expanded detection of genetically driven transcriptome abnormalities by analyzing gene expression, allele-specific expression, and alternative splicing from multitissue RNA-sequencing data, and demonstrate that each signal informs unique classes of R…

  DOI

Recent grants

• NIH Grant R01HG009125

  NIH · $791k · 2020

• Significance Based Procedures for Mining and Prediction of Large Data Sets

  NSF · $210k · 2009–2013

• NIH Grant R01MH101819

  NIH · $1.3M · 2017

Frequent coauthors

• Fred A. Wright

  47 shared

• Tuuli Lappalainen

  Science for Life Laboratory

  42 shared

• Ayellet V. Segrè

  Broad Institute

  41 shared

• Charles M. Perou

  UNC Lineberger Comprehensive Cancer Center

  40 shared

• Gad Getz

  39 shared

• Roderic Guigó

  Pompeu Fabra University

  38 shared

• Sarah Kim-Hellmuth

  37 shared

• Joel S. Parker

  University of North Carolina at Chapel Hill

  35 shared

Awards & honors

• Andrew B. Nobel Distinguished Professor

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