Andrew McCulloch

About

Andrew McCulloch is a Distinguished Professor in Bioengineering at UC San Diego, holding the Shu Chien Chancellor's Endowed Chair in Engineering and Medicine. He is the Director of the UC San Diego Institute for Engineering in Medicine and the Interfaces Graduate Training Program. His research focuses on in-vitro, in-vivo, and computational cardiac mechanics and physiology in health and disease. Professor McCulloch directs the Cardiac Mechanics Research Group, where his team investigates the relationships between the cellular and extracellular structure of cardiac muscle and the electrical and mechanical function of the heart during ventricular remodeling and cardiac arrhythmia. His work involves using experimental and computational models, genetically engineered animal models, tissue engineering techniques such as microlithography and microfluidics, and computational modeling combined with fluorescence optical mapping to study excitation-contraction coupling and mechanoelectric feedback in cardiac tissue. Additionally, he explores signal transduction pathways related to calcium cycling and hypertrophy, along with developing new technologies for high-throughput cardiac phenotyping in model organisms. Professor McCulloch joined UC San Diego's faculty in 1987, served as the department chair, and is a senior fellow at the San Diego Supercomputer Center. He is also a member of the Whitaker Institute for Biomedical Engineering and the UCSD/Salk Institute for Molecular Medicine.…

Research topics

• Biology
• Pathology
• Medicine
• Computer Science
• Biomedical engineering
• Computational biology
• Genetics
• Cell biology
• Materials science
• Chemistry

Selected publications

• Research Priorities for Heart Failure With Preserved Ejection Fraction

  Circulation · 2020 · 401 citations

  Heart failure with preserved ejection fraction (HFpEF), a major public health problem that is rising in prevalence, is associated with high morbidity and mortality and is considered to be the greatest unmet need in cardiovascular medicine today because of a general lack of effective treatments. To address this challenging syndrome, the National Heart, Lung, and Blood Institute convened a working group made up of experts in HFpEF and novel research methodologies to discuss research gaps and to pr…

  DOI

• Cardiac cell type–specific gene regulatory programs and disease risk association

  Science Advances · 2021 · 140 citations

  expression and action potential repolarization. Overall, this atlas of human cardiac cCREs provides the foundation for illuminating cell type-specific gene regulation in human hearts during health and disease.

  DOI

• Direct 3D bioprinting of cardiac micro-tissues mimicking native myocardium

  Biomaterials · 2020 · 139 citations

  DOI

• Macrophages on the run: Exercise balances macrophage polarization for improved health

  Molecular Metabolism · 2024-10-30 · 21 citations

  reviewOpen access

  OBJECTIVE: Exercise plays a crucial role in maintaining and improving human health. However, the precise molecular mechanisms that govern the body's response to exercise or/compared to periods of inactivity remain elusive. Current evidence appears to suggest that exercise exerts a seemingly dual influence on macrophage polarization states, inducing both pro-immune response M1 activation and cell-repair-focused M2 activation. To reconcile this apparent paradox, we leveraged a comprehensive meta-a…

  PublisherDOI

• Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport

  Cell Metabolism · 2024-09-01 · 10 citations

  articleOpen access

  Insufficient energy intake to meet energy expenditure demands of physical activity can result in systemic neuroendocrine and metabolic abnormalities in activity-dependent anorexia and relative energy deficiency in sport (REDs). REDs affects >40% of athletes, yet the lack of underlying molecular changes has been a hurdle to have a better understanding of REDs and its treatment. To assess the molecular changes in response to energy deficiency, we implemented the "exercise-for-food" paradigm, in wh…

  PublisherDOI

Recent grants

• NIH Grant R29HL041603

  NIH · $505k · 1993

• NIH Grant P01HL043026

  NIH · $12.9M · 2007

• NIH Grant P01HL046345

  NIH · $36.2M · 2014

Frequent coauthors

• Jeffrey H. Omens

  University of California, San Diego

  221 shared

• Roy C. P. Kerckhoffs

  University of California, San Diego

  63 shared

• Andrew G. Edwards

  University of California, San Diego

  49 shared

• Michael Regnier

  University of Washington

  43 shared

• Giovanni Paternostro

  Sanford Burnham Prebys Medical Discovery Institute

  42 shared

• Kevin P. Vincent

  University of California, San Diego

  41 shared

• Jeff Omens

  40 shared

• Anushka Michailova

  University of California, San Diego

  40 shared

Labs

• Cardiac Mechanics Research GroupPI

Awards & honors

• NSF Presidential Young Investigator (1991-96)
• Fellow of the American Institute for Medical and Biological…

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