Andrea H. Brand

About

Andrea H. Brand is the Frederick L. Ehrman Professor of Cell Biology and a Professor in the Department of Neuroscience at NYU Grossman School of Medicine. She holds positions in both the Department of Cell Biology and the Department of Neuroscience. Her educational background includes a PhD from the University of Cambridge, and she has completed fellowship training at Harvard Medical School and Harvard University, including a Leukemia Society Special Fellowship and a Helen Hay Whitney Fellowship. Her research focuses on neural stem cell biology, epigenetic regulation, and cell differentiation, with significant contributions to understanding neural stem cell quiescence, differentiation programs in inhibitory neuron production, and cell-type-specific chromatin modifications. Her work involves advanced genomic and epigenomic techniques, such as DamID, to identify genomic targets and understand mechanisms underlying neural development and stem cell maintenance.

Research topics

• Biology
• Cell biology
• Internal medicine
• Medicine
• Cognitive science
• Pathology
• Immunology
• Genetics
• Neuroscience
• Psychology

Selected publications

• A conserved differentiation program facilitates inhibitory neuron production in the developing mouse and human cerebellum

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-04-10 · 1 citations

  preprintOpen access

  Summary Understanding the molecular mechanisms driving lineage decisions and differentiation during development is challenging in complex systems with a diverse progenitor pool, such as the mammalian cerebellum. Importantly, how different transcription factors cooperate to generate neural diversity and the gene regulatory mechanisms that drive neuron production, especially during the late stages of cerebellar development are poorly understood. Here, we used single cell RNA-sequencing (scRNA-seq)…

  PublisherOA PDFDOI

• Neural stem cell quiescence is actively maintained by the epigenome

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-05-15 · 1 citations

  preprintOpen accessSenior authorCorresponding

  Summary Homeostasis and repair of the nervous system is maintained by a population of resident neural stem cells (NSCs) retained in a state of reversible cell cycle arrest called quiescence. quiescent NSCs can resume proliferation in response to different physiological stimuli, such as diet or injury. Reactivation of NSCs requires changes in gene expression, much of which is regulated at the epigenomic level. We mapped, comprehensively and in vivo , the dynamic epigenomic changes in NSC chromati…

  PublisherOA PDFDOI

• A conserved differentiation programme facilitates inhibitory neuron production in the developing mouse and human cerebellum

  Development · 2025-11-25 · 1 citations

  articleOpen access

  Understanding the molecular mechanisms driving lineage decisions and differentiation during development is challenging in complex systems with a diverse progenitor pool, such as the mammalian cerebellum. Importantly, how different transcription factors cooperate to generate neural diversity and the gene regulatory mechanisms that drive neuron production, especially during the late stages of cerebellum development, are poorly understood. We used single cell RNA-sequencing (scRNA-seq) to investiga…

  PublisherOA PDFDOI

• Targeting the acetyltransferase NAT10 corrects pathologies in human frontotemporal dementia neurons and extends lifespan in an in vivo <i>Drosophila</i> tauopathy model

  bioRxiv (Cold Spring Harbor Laboratory) · 2024-10-22 · 1 citations

  preprintOpen access

  ABSTRACT Disruption of the neuronal nuclear membrane and perturbation of nucleocytoplasmic transport are features of neurodegenerative diseases, including Alzheimer’s disease, that involve the microtubule-associated protein tau (MAPT). We previously identified that missense and splicing mutations in the MAPT gene, causal for frontotemporal dementia, result in nuclear envelope deformation and disrupted nucleocytoplasmic transport in human neurons. This is most likely due to microtubule mechanical…

  PublisherOA PDFDOI

• Nonpharmaceutical options for pediatric headache: Nutraceuticals, manual therapies, and acupuncture

  Elsevier eBooks · 2021-10-22 · 1 citations

  book-chapter
  PublisherDOI

Frequent coauthors

• Tony D. Southall

  Imperial College London

  72 shared

• Jelle van den Ameele

  University of Cambridge

  49 shared

• Boris Egger

  University of Fribourg

  47 shared

• Seth W. Cheetham

  University of Queensland

  32 shared

• Emma L. Rawlins

  Wellcome/MRC Cambridge Stem Cell Institute

  30 shared

• John C. Marioni

  European Bioinformatics Institute

  30 shared

• Dawei Sun

  30 shared

• Walfred W. C. Tang

  Wellcome/Cancer Research UK Gurdon Institute

  30 shared

Labs

• Health Tech HubPI

Awards & honors

• Fellowship, Harvard Medical School, Leukemia Society
• Fellowship, Harvard University, Helen Hay Whitney Fellow

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