Andrea Graham

About

Andrea L. Graham is the head researcher of the Graham Group, bringing a background in ecology and evolutionary biology that has shaped her approach to immunoparasitology. Her research integrates the fields of immunology, ecology, parasitology, and evolutionary biology, working at the interface of these disciplines alongside both empiricists and theoreticians. The group’s work involves complex experiments and fieldwork, investigating immune-mediated life history tradeoffs, physiology, and the ecology of host-parasite interactions. Andrea’s leadership fosters a collaborative environment that spans multiple areas of expertise, reflecting her commitment to advancing understanding of immune function in ecological and evolutionary contexts.

Research topics

• Biology
• Immunology
• Medicine
• Virology
• Environmental health
• Microbiology

Selected publications

• Immune life history, vaccination, and the dynamics of SARS-CoV-2 over the next 5 years

  Science · 2020 · 328 citations

  The future trajectory of the coronavirus disease 2019 (COVID-19) pandemic hinges on the dynamics of adaptive immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, salient features of the immune response elicited by natural infection or vaccination are still uncertain. We use simple epidemiological models to explore estimates for the magnitude and timing of future COVID-19 cases, given different assumptions regarding the protective efficacy and duration of the ad…

  DOI

• Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes

  Science · 2021 · 254 citations

  Given vaccine dose shortages and logistical challenges, various deployment strategies are being proposed to increase population immunity levels to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Two critical issues arise: How timing of delivery of the second dose will affect infection dynamics and how it will affect prospects for the evolution of viral immune escape via a buildup of partially immune individuals. Both hinge on the robustness of the immune response elicited by a sing…

  DOI

• Altered Immunity of Laboratory Mice in the Natural Environment Is Associated with Fungal Colonization

  Cell Host & Microbe · 2020 · 167 citations

  DOI

• Convergence and divergence of individual immune responses over the life course

  Science · 2025-08-07 · 19 citations

  reviewOpen access

  Three ingredients create the strikingly variable immune trajectories observed across human populations: (i) genetic variation, (ii) individual-scale generation of additional genetic diversity solely in lymphocytes, and (iii) collision of these processes with a changing environment through life, triggering plastic responses that can have lasting effects. We explore what generates or reduces immune variation, integrating recent empirical advances with potential overarching evolutionary principles.…

  PublisherOA PDFDOI

• Architecture of the neutrophil compartment

  Nature · 2025-12-03 · 19 citations

  articleOpen access
  PublisherOA PDFDOI

Recent grants

• RCN: Infectious Disease Evolution Across Scales

  NSF · $500k · 2014–2019

• DISSERTATION RESEARCH: The effects of multi-species interactions on the community structure of parasites

  NSF · $16k · 2015–2017

Frequent coauthors

• Bryan T. Grenfell

  Princeton Public Schools

  66 shared

• C. Jessica E. Metcalf

  Princeton University

  49 shared

• Ken Cadwell

  34 shared

• P’ng Loke

  National Institutes of Health

  34 shared

• Kathryn Watt

  University of Edinburgh

  30 shared

• Daniel H. Nussey

  University of Edinburgh

  26 shared

• Judith E. Allen

  Wellcome Centre for Cell-Matrix Research

  23 shared

• Andrew F. Read

  Pennsylvania State University

  22 shared

Labs

• The Graham GroupPI

  Ecology and evolutionary biology approach to immunoparasitology

Education

• Ph.D., Ecology & Evolutionary Biology

  Cornell University

• Postdoc, Immunology

  University of Edinburgh

  2006

• q, Dynamic Epidemiology

  Oxford University

  1997

Similar researchers at Princeton University

• David Wilcoveh-85
• Jonathan Levineh-75