Alfred Chen

About

Alfred Chen is an Assistant Professor at UC Irvine's Donald Bren School of Information & Computer Sciences, where he leads the AS^2Guard (Autonomous & Smart Systems Guard) research group. His research broadly focuses on the security and privacy of computer technologies that are of high criticality to daily life and society. He concentrates on security and privacy issues in emerging AI, systems, and network technologies, especially those with significant societal impacts such as AI-enabled autonomous vehicles and intelligent transportation systems. His major research theme involves proactively addressing security challenges through systematic problem analysis and design, utilizing techniques such as optimization, static and dynamic program analysis, formal methods, defense principles, and data-driven approaches. His work has developed methods to systematically discover, analyze, detect, and fix security vulnerabilities in a wide range of important computer systems and components, including AI and software stacks in autonomous cars, drones, robots, intelligent traffic lights, smartphone systems, critical network protocols like TCP and DNS, GUI systems, and access control systems.

Research topics

• Medicine
• Surgery
• Computer Science
• Medical physics
• Nuclear medicine
• Radiology
• Psychology
• Family medicine
• Pathology
• Library science

Selected publications

• Ipsilateral radiation for squamous cell carcinoma of the tonsil: American Radium Society appropriate use criteria executive summary

  Head & Neck · 2020 · 28 citations

  BACKGROUND: We conducted the current systemic review to provide up-to-date literature summary and optimal evidence-based recommendations for ipsilateral radiation for squamous cell carcinoma of the tonsil. METHODS: We performed literature search of peer-reviewed journals through PubMed. The search strategy and subject-specific keywords were developed based on the expert panel's consensus. Articles published from January 2000 to May 2020 with full text available on PubMed and restricted to the En…

  DOI

• Systematic review of postoperative therapy for resected squamous cell carcinoma of the head and neck: Executive summary of the American Radium Society appropriate use criteria

  Head & Neck · 2020 · 23 citations

  BACKGROUND: The aims of this systematic review are to (a) evaluate the current literature on the impact of postoperative therapy for resected squamous cell carcinoma of the head and neck (SCCHN) on oncologic and non-oncologic outcomes and (b) identify the optimal evidence-based postoperative therapy recommendations for commonly encountered clinical scenarios. METHODS: An analysis of the medical literature from peer-reviewed journals was conducted using the Preferred Reporting Items for Systemati…

  DOI

• Barriers to health equity in the United States of America: can they be overcome?

  International Journal for Equity in Health · 2025-02-07 · 22 citations

  reviewOpen access1st authorCorresponding

  Health equity-defined by the Centers for Disease Control and Prevention as " the state in which everyone has a fair and just opportunity to attain their highest level of health-" represents one of the most critical issues facing modern societies. While seemingly an increasing focus of policymakers in recent years, this concept is hardly a novel one. In 1948, the inaugural Constitution of the newly founded World Health Organization clearly stated that "the enjoyment of the highest attainable stan…

  PublisherOA PDFDOI

• Stereotactic Body Radiation Therapy for Apical Lung Tumors: Dosimetric Analysis of the Brachial Plexus and Preliminary Clinical Outcomes

  Practical Radiation Oncology · 2021 · 12 citations

  Senior authorCorresponding
  DOI

• HPV-Mediated Radiosensitivity in Oropharyngeal Squamous Cell Carcinoma: Molecular Mechanisms and Cellular Pathways

  Current Oncology Reports · 2025-04-11 · 5 citations

  reviewOpen access1st authorCorresponding

  PURPOSE OF REVIEW: While the oncogenic potential of HPV has been well-established in other disease sites (e.g. cervix, vulva, anus), it is increasingly evident that a significant proportion of oropharyngeal cancer cases are related to the virus. Although considerable progress has been made in the understanding of this disease with respect to its underlying biology and clinical behavior, numerous questions persist. From a therapeutic standpoint, HPV-positive oropharyngeal cancer has been shown to…

  PublisherDOI

Frequent coauthors

• D. Gregory Farwell

  Hospital of the University of Pennsylvania

  54 shared

• James A. Purdy

  49 shared

• Megan E. Daly

  University of California, Davis

  48 shared

• Quang Luu

  27 shared

• Srinivasan Vijayakumar

  20 shared

• Derick Lau

  19 shared

• Paul J. Donald

  18 shared

• M. Kara Bucci

  17 shared

Awards & honors

• ICS Researchers Awarded Best Technical Poster at NDSS (2024)

Similar researchers at University of California, Irvine

• Pierre Baldih-121
• Gene Tsudikh-82
• Padhraic Smythh-78