Liver Transplantation Using Normothermic Regional Perfusion - A Single Center Experience

American Journal of Transplantation · 2025-01-01

Post-Transplant Cyclophosphamide (PTCy) for HLA-Matched HCT in Pediatric and Young Adults with Acute Leukemias and MDS

Transplantation and Cellular Therapy · 2025-02-01

FRI-323 Redundant yet distinct role of Vacuole membrane protein 1 and transmembrane protein 41B in regulating hepatic lipoprotein secretion and autophagy in metabolic dysfunction-associated steatohepatitis

Journal of Hepatology · 2025-05-01

Face responses in Amygdala and Entorhinal Cortex encode interpersonal relationships within macaque social groups

Journal of Vision · 2025-07-15

Face information in ventral visual cortex is primarily structural and encodes face identities by their locations in a structural “face space”. Face responsive regions in medial temporal lobe memory structures, including amygdala, associate specific identities with personal characteristics, such as aggressiveness (expression) and social rank. Here, we found that face responsive regions of amygdala and entorhinal cortex also encoded interpersonal relationships between individuals in stable social groups of 5–10 macaque monkeys. This naturally required that individual neurons encode information about multiple individuals, which depended on a radial coding format, centered on individual monkeys and rate encoding the relationship levels of other monkeys to that central individual. Thus, a given neuron might represent how submissive every other monkey was to monkey X. To characterize interpersonal relationships within four macaque social groups, we collected multi-camera surveillance videos in both indoor and outdoor runs across a three-month time frame. We analyzed these videos to measure frequencies of affiliative, aggressive, and submissive behaviors between all pairs of monkeys within each group. Two subject monkeys from the same group were studied with linear array probe recording in amygdala and adjacent entorhinal cortex while viewing photographs of monkeys from the home, neighboring, and unfamiliar groups. We analyzed neural coding of personal social knowledge about home and neighboring groups, using unfamiliar monkeys as a control. We found that many neurons in amygdala and entorhinal cortex encode social knowledge about interpersonal relationships involving either the subject monkey relating to other monkeys (self to other) or relationships not involving the self (other to other). In both cases, information about interpersonal relationships was represented in a radial coding format, in which the self or another monkey was the central node and the responses to other monkeys’ faces correlated with a behavioral frequency relative to the central monkey.

New Donor Strategies and Their Association with One-Year Heart Transplant Survival

American Journal of Transplantation · 2025-08-01

Use of Gonadal Shielding for Fertility Preservation in Males with Non-Hematologic Malignancies Undergoing HCT

Transplantation and Cellular Therapy · 2025-02-01

Murine gut microbiota dysbiosis via enteric infection modulates the foreign body response to a distal biomaterial implant

bioRxiv (Cold Spring Harbor Laboratory) · 2025-01-17 · 1 citations

Abstract The gut microbiota influences systemic immunity and the function of distal tissues, including the brain, liver, skin, lung, and muscle. However, the role of the gut microbiota in the foreign body response (FBR) and fibrosis around medical implants is largely unexplored. To investigate this connection, we perturbed the homeostasis of the murine gut microbiota via enterotoxigenic Bacteroides fragilis (ETBF) infection and implanted the synthetic polymer polycaprolactone (PCL) into a distal muscle injury. ETBF infection in mice led to increased neutrophil and γδ T cell infiltration into the PCL implant site. ETBF infection alone promoted systemic inflammation and increased levels of neutrophils in the blood, spleen, and bone marrow. At the PCL implant site, we found significant changes in the transcriptome of sorted fibroblasts but did not observe gross ETBF- induced differences in the fibrosis levels after 6 weeks. These results demonstrate the ability of the gut microbiota to mediate long-distance effects such as immune and stromal responses to a distal biomaterial implant. Significance Statement The foreign body response to implants leads to chronic inflammation and fibrosis that can be highly variable in the general patient population. Here, we demonstrate that gut dysbiosis via enteric infection promoted systemic inflammation and increased immune cell recruitment to an anatomically distant implant site. These results implicate the gut microbiota as a potential source of variability in the clinical biomaterial response and illustrate that the local tissue environment can be influenced by host factors that modulate systemic interactions.

Analytical performance of targeted long-read HiFi sequencing to detect pharmacogenomic HLA-A and -B alleles implicated in drug-induced hypersensitivity reactions

Human Immunology · 2025-09-01

Long-term follow up of Alemtuzumab induction for pediatric renal transplant: incidence of PTLD

American Journal of Transplantation · 2025-01-01 · 1 citations

Murine gut microbiota dysbiosis via enteric infection modulates the foreign body response to a distal biomaterial implant

Proceedings of the National Academy of Sciences · 2025-05-12 · 4 citations

The gut microbiota influences systemic immunity and the function of distal tissues, including the brain, liver, skin, lung, and muscle. However, the role of the gut microbiota in the foreign body response and fibrosis is largely unexplored. To investigate this connection, we perturbed the homeostasis of the murine gut microbiota via infection with the pathogenic bacterial species enterotoxigenic Bacteroides fragilis (ETBF) and implanted particulate material (mean particle size <600 μm) of the synthetic polymer polycaprolactone (PCL) into a distal muscle injury. ETBF infection in mice led to increased neutrophil and γδ T cell infiltration into the PCL implant site. ETBF infection alone promoted systemic inflammation, increased levels of neutrophils in lymphoid tissues, and altered skeletal muscle gene expression. At the PCL implant site, we found significant changes in the transcriptome of sorted stromal cells between infected and control mice, including differences related to ECM components such as proteoglycans and glycosaminoglycans. However, we did not observe ETBF-induced differences in fibrosis levels. These results demonstrate the ability of the gut microbiota to mediate long-distance effects such as immune and stromal responses to a distal biomaterial implant.