John Fraser Wright
VerifiedUniversity of Pennsylvania · Rehabilitation Medicine
Active 1969–2024
Research topics
- Immunology
- Biology
- Genetics
- Cancer research
- Medicine
Selected publications
Science Translational Medicine · 2021 · 157 citations
- Cancer research
- Medicine
- Biology
allelic correction in clinical-scale gcHBB-SCD manufacturing. After transplant into immunodeficient NSG mice, 20% gene correction was achieved with multilineage engraftment. The long-term safety, tumorigenicity, and toxicology study demonstrated no evidence of abnormal hematopoiesis, genotoxicity, or tumorigenicity from the engrafted gcHBB-SCD drug product. Together, these preclinical data support the safety, efficacy, and reproducibility of this gene correction strategy for initiation of a phase 1/2 clinical trial in patients with SCD.
Frequent coauthors
- 135 shared
Katherine A. High
Rockefeller University
- 48 shared
Albert M. Maguire
Children's Hospital of Philadelphia
- 40 shared
Jean Bennett
University of Pennsylvania
- 36 shared
Valder R. Arruda
- 35 shared
Federico Mingozzi
Ark Therapeutic (United States)
- 32 shared
Bernd Hauck
- 31 shared
Eric A. Pierce
Harvard University
- 28 shared
Alberto Auricchio
Scuola Superiore Meridionale
- Resume-aware match score
- Save to shortlist
- AI-drafted outreach
See your match with John Fraser Wright
PhdFit ranks faculty by your research interests, methods, and publications — grounded in their actual work, not templates.
- Free to start
- No credit card
- 30-second signup