J. Alan Diehl
University of Pennsylvania · Rehabilitation Medicine
Active 1991–2024
Research topics
- Biology
- Cancer research
- Oncology
- Pathology
- Medicine
- Cell biology
- Internal medicine
- Biochemistry
Selected publications
Nature Cell Biology · 2022 · 169 citations
- Cancer research
- Biology
- Cell biology
fibroblasts displayed significant defects in collagen biosynthesis and deposition and a reduced ability to support angiogenesis. Mechanistically, ATF4 regulates the expression of the Col1a1 gene and levels of glycine and proline, the major amino acids of collagen. Analyses of human melanoma and pancreatic tumours revealed a strong correlation between ATF4 and collagen levels. Our findings establish stromal ATF4 as a key driver of CAF functionality, malignant progression and metastasis.
Current Protocols in Stem Cell Biology · 2020 · 90 citations
- Medicine
- Cancer research
- Oncology
) Support Protocol: Production of RN in HEK293T cell conditioned medium.
Recent grants
Nuclear Accumulation of D-type Cyclins and Oncogenesis
NIH · $5.9M · 2001–2024
NIH · $1.5M · 2010
Mechanisms of Esophageal Carcinogenesis
NIH · $48.5M · 2003–2024
NIH · $1.6M · 2016
NIH · $23.5M · 2021
Frequent coauthors
- 151 shared
Anil K. Rustgi
Columbia University Irving Medical Center
- 145 shared
Hiroshi Nakagawa
- 132 shared
Andres J. Klein‐Szanto
- 115 shared
Dariusz Pytel
Medical University of South Carolina
- 104 shared
Meenhard Herlyn
- 75 shared
Serge Y. Fuchs
University of Pennsylvania
- 68 shared
Constantinos Koumenis
University of Pennsylvania
- 65 shared
Phyllis A. Gimotty
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