About

Saul Suster, MD, is a professor in the Department of Pathology, Immunology and Laboratory Medicine at Rutgers New Jersey Medical School. He holds a medical degree obtained in 1976 from Catholic University. Dr. Suster is involved in clinical activities within the department and is affiliated with University Hospital in Newark. His professional licensure is registered in New Jersey. The information provided indicates his participation in various insurance networks, reflecting his engagement in clinical practice and patient care. Further details about his research focus or specific contributions are not included in the provided text.

Research topics

• Biology
• Pathology
• Medicine
• Endocrinology
• Genetics

Selected publications

• Acantholytic squamous cell carcinoma of the lung with pseudoglandular features: clinicopathologic study of 14 cases

  Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · 2025-07-03

  articleSenior author
  PublisherDOI

• Superficial plexiform schwannoma of the skin and subcutis: Clinicopathological study of 48 cases

  Histopathology · 2025-08-27 · 2 citations

  article

  AIMS: To study the clinicopathological characteristics of a large cohort of cutaneous plexiform schwannoma. METHODS AND RESULTS: A total of 48 cases of plexiform schwannoma were collected. Clinical and pathological features including age, location, location within the dermis, histology, immunohistochemical features, treatment and clinical follow-up were collected by reviewing glass slides or abstracted from the medical record. The patients were 22 women and 26 men aged 6-84 years (mean: 43). The tumours arose in the extremities in 17 patients, trunk in 17, head and neck in 12, and buttock in 2. The tumours were all superficially located and confined to the dermis, subcutis, or both and measured from 0.3 to 6.0 cm (mean: 2.0 cm). The tumours were all well-circumscribed and showed a multinodular, plexiform pattern of growth. Histologically they showed features of Antoni type A in 30 cases, Antoni type B in 3, and a combination of type A and type B in 15. Immunohistochemical stains in all cases were positive for S100 and SOX10 and showed peripheral condensation of EMA and CD34 positive perineurial cells. The Ki-67 index was low in all cases (1%-2%). Seven patients (12.5%) had type 2 neurofibromatosis (NF2). All patients were treated by complete surgical excision. Clinical follow-up from 13 months to 5 years was available in 16 patients; there was no evidence of recurrence or metastases. CONCLUSIONS: Plexiform schwannomas arising in the skin and subcutis are indolent. A subset shows an association with neurofibromatosis type 2.

  PublisherDOI

• Large Cell Neuroendocrine Carcinoma of the Lung: In Search for a Better Definition

  Advances in Anatomic Pathology · 2025-06-26

  articleSenior author

  Pulmonary large cell neuroendocrine carcinoma (LCNEC) represents a controversial entity that has been associated with difficulties for diagnosis. The sources for these difficulties are multiple, including lack of stringent morphologic criteria, variable immunohistochemical profile, and variable molecular profile that share overlap with other tumors of the lung. There appears to exist a spectrum of lesions in the lung that have the potential to overlap with LCNEC, compounding the difficulties inherent in making a diagnosis for what is essentially a rare lesion that most general pathologists have limited experience with. Moreover, the broad definition of LCNEC by the World Health Organization (WHO) has the potential for classifying tumors that may not clearly belong in this group under this category. Herein we will discuss the criteria for light microscopic, immunohistochemical, and molecular diagnostic features of LCNEC along with a discussion of some of the problems encountered in the interpretation of these tumors. The differential diagnosis is also discussed, including tumors that may show similar neuroendocrine-like morphology.

  PublisherDOI

• 539 Anaplastic Thyroid Carcinoma: Clinicopathologic Study of 144 Cases with Special Emphasis on the Spectrum of Histologic Features

  Laboratory Investigation · 2025-03-01

  articleOpen accessSenior author
  PublisherOA PDFDOI

• OBITUARY: RENE J. BUESA, Ph.D., HTL (ASCP)

  Annals of Diagnostic Pathology · 2025-05-23

  article1st authorCorresponding
  PublisherDOI

• Immunohistochemical evaluation of ERG expression in soft tissue tumours: a tissue microarray study of 489 cases

  Journal of Clinical Pathology · 2025-08-22

  articleSenior author

  AIMS: ) in a large number of soft tissue neoplasms using a tissue microarray technique. METHODS: 489 cases of soft tissue neoplasms, including benign and malignant entities, were collected from the files of the respective institutions and constructed into tissue microarrays. Tissue microarrays were stained for ERG immunohistochemistry using two antibodies, EP111 and EPR3864. RESULTS: A total of 25 cases (5.1%) were identified that were positive for ERG using the monoclonal antibody EP111 and 15 cases (3%) using the monoclonal antibody EPR3864, including rhabdomyosarcoma, peripheral nerve sheath tumours, synovial sarcoma, myxofibrosarcoma, epithelioid sarcoma, dermatofibrosarcoma protuberans, low-grade fibromyxoid sarcoma, nodular fasciitis and dedifferentiated liposarcoma. The most consistently stained tumours included synovial sarcoma, rhabdomyosarcoma and benign and malignant peripheral nerve sheath tumours. Various other fibroblastic proliferations, including dermatofibrosarcoma protuberans, myxofibrosarcoma, low-grade fibromyxoid sarcoma and nodular fasciitis, also showed positive staining in a small fraction of cases. One case of dedifferentiated liposarcoma showed nuclear positivity for ERG, and one case of epithelioid sarcoma was also positive. CONCLUSIONS: This study supports the value of ERG as a highly sensitive and specific marker for the diagnosis of vascular neoplasms but also demonstrates rare cases of aberrant staining and underscores the need to assess soft tissue tumours using a panel of stains and interpret the results of immunohistochemistry in the appropriate histological and clinical context.

  PublisherDOI

• Histologic features, growth patterns and classification of atypical thymomas

  Mediastinum · 2025-06-01 · 1 citations

  reviewOpen accessSenior author

  Atypical thymomas are a rare form of primary thymic epithelial neoplasm that are characterized by conservation of most of the organotypical features of thymic differentiation, but show atypical cytological features. The spectrum of histologic features and growth patterns these tumors can exhibit have not been extensively documented or illustrated in the literature. The basic histologic growth patterns seen in atypical thymomas include the epithelioid or "Squamoid" subtype and the spindle cell subtype. The histologic picture may often be confused with thymic carcinomas or metastatic disease, in particular squamous cell carcinoma due to the overlap in histologic features. In addition, these subtypes may be seen in combination with each other or in combination with conventional types of thymoma including type A, type AB, type B1 and type B2. Cases of thymic carcinoma arising from atypical thymoma have also been documented in the literature. The biologic behavior of atypical thymomas is intermediate between conventional thymoma and thymic carcinoma. The tumors tend to present with aggressive behavior and an increased rate of metastasis and thus achieving the correct diagnosis is of utmost importance. We present a review of the various morphologic appearances of these tumors to emphasize the wide spectrum of histologic features that they can display, with a discussion of the current nomenclature and approach to these neoplasms.

  PublisherDOI

• On delusional personalities in pathology

  Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · 2025-02-21

  letter1st authorCorresponding
  PublisherDOI

• Pseudosquamous Adenocarcinoma of the Lung

  The American Journal of Surgical Pathology · 2024-05-20

  articleSenior authorCorresponding

  Pseudosquamous adenocarcinoma of the lung is an unusual morphologic variant of poorly differentiated non-small cell lung carcinoma that superficially resembles a squamous cell carcinoma. We have examined 10 cases of these tumors in 4 women and 6 men, aged 47 to 93 years. The tumors were all peripheral and measured from 1.5 to 5.5 cm. All cases were characterized by solid nests of large polygonal tumor cells containing atypical nuclei with abundant cytoplasm and sharp cell borders, adopting a pavement-like architecture that simulated squamous cell carcinoma. Some cases demonstrated intracytoplasmic hyaline inclusions suggestive of keratinization. The nests of tumor cells often showed central comedo-like areas of necrosis. Intercellular bridges were not seen in any of the cases. The tumors often displayed marked clearing of the cytoplasm enhancing their epidermoid appearance. In 4 cases, the solid pseudosquamous areas were seen to merge with a focal lepidic adenocarcinoma component, and in 1 case, abortive microscopic foci of acinar differentiation were also noted within the tumor. One case showed focal sarcomatoid spindle cell areas. The tumor cells were negative for p40 and CK5/6 and labeled with TTF1 or Napsin-A, confirming an adenocarcinoma phenotype. Clinical follow-up information was available in 8 patients; 6 patients died of their tumors between 6 months to 11 years after diagnosis (mean: 3.1 y). One patient died of complications related to surgery and one patient with a low-stage tumor died at 27 years from other causes. Solid pattern adenocarcinomas can be confused for squamous cell carcinoma and may require immunohistochemistry to determine their true phenotype.

  PublisherDOI

• Insulinoma-Associated Protein-1 Expression in Lymphoepithelial Carcinoma of the Thymus: A Potential Pitfall for Diagnosis With Neuroendocrine Carcinomas of the Thymus

  Archives of Pathology & Laboratory Medicine · 2024-06-17 · 4 citations

  articleOpen accessSenior author

  CONTEXT.—: Insulinoma-associated protein-1 (INSM1) is a recently developed immunohistochemical marker claimed to be highly specific and sensitive for the diagnosis of neuroendocrine malignancies. Recent studies, however, have demonstrated that this marker can also be expressed in non-neuroendocrine neoplasms including squamous cell carcinoma of the thymus. OBJECTIVE.—: To examine INSM1 expression in lymphoepithelial thymic carcinomas. DESIGN.—: Thirty-four cases of lymphoepithelial carcinoma of the thymus were examined by immunohistochemistry or in situ hybridization for INSM1, synaptophysin, chromogranin, CD5, CD117, Epstein-Barr virus-encoded small ribonucleic acid (EBER), and Ki-67. Basic clinical information was abstracted from the medical record. RESULTS.—: The patients were 14 women and 20 men, aged 20 to 85 years. The tumors arose in the anterior mediastinum without any previous history or evidence of malignancy at other sites. Immunohistochemical staining showed moderate to strong positivity of the tumor cells for INSM1 in 65% of cases (22 of 34), focal weak positivity in 20% (7 of 34), and negative staining in 5 cases. Chromogranin staining was focally and weakly positive in 1 case, and synaptophysin showed only focal weak positivity in scattered tumor cells in 12 cases. No significant correlation could be identified between the pattern and intensity of staining for INSM1 and staining for CD5, CD117, and Ki-67. CONCLUSIONS.—: INSM1 positivity in lymphoepithelial carcinoma of the thymus may represent a pitfall for diagnosis, particularly in small biopsy samples. Awareness of this finding may be of importance to avoid misdiagnosis of neuroendocrine malignancy.

  PublisherDOI

Frequent coauthors

• César A. Moran

  The University of Texas MD Anderson Cancer Center

  591 shared

• Ondřej Hes

  Biopticka Laborator (Czechia)

  290 shared

• Delia Pérez‐Montiel

  Instituto Nacional de Cancerología

  220 shared

• Alberto M. Marchevsky

  218 shared

• Henry D. Tazelaar

  Mayo Clinic Hospital

  170 shared

• William D. Travis

  Memorial Sloan Kettering Cancer Center

  170 shared

• Feng‐Ming Kong

  University of Hong Kong - Shenzhen Hospital

  170 shared

• Mary Beth Beasley

  Icahn School of Medicine at Mount Sinai

  170 shared

Education

• M.D.

  Catholic University

  1976