About

Dr. George Hodge is an emeritus associate professor in Textile Engineering, Chemistry and Science at NC State University. His teaching has included courses in the Textile Supply Chain Management concentration, and his administrative roles have encompassed positions such as assistant dean for program development in the Graduate School, associate department head and director of graduate programs in the TATM department, and program director for Textile Technology. His research areas include supply chain management, electronic business, data mining, information quality, and enterprise integration. Dr. Hodge has been actively involved in professional organizations, serving as vice president for profession development for the ASCM Triangle Chapter and working with the APICS Textile and Apparel Specific Industry Group to survey information systems used in the textile industry. He contributed to the creation of the IBM Computer Integrated Manufacturing (CIM) facility at NC State and served on the board for CIM in Higher Education. His academic achievements include a Ph.D. in Industrial Engineering from NC State, an MS in Industrial and Systems Engineering from Ohio State, and a BS in Nuclear Engineering from NC State. Recognized for his contributions, he received the NCSU Libraries Faculty Award in 2002 and was named Outstanding Teacher of the Year in 1994.

Research topics

• Medicine
• Internal medicine
• Endocrinology

Selected publications

• Vasoactive intestinal peptide infusion reverses existing renal interstitial fibrosis via a blood pressure independent mechanism in the rat

  European Journal of Pharmacology · 2020 · 6 citations

  • Medicine
  • Internal medicine
  • Endocrinology

  Dialysis requiring renal failure is a silent epidemic. Despite an annual mortality of 24% the dialysis population has increased by 1-4% per annum. Regardless of the initial injury, tubulointerstitial fibrosis is a feature of the renal pathology and it inversely correlates with declining renal function. Current agents display little efficacy against tubulointerstitial fibrosis. Clearly, therapies effective against tubulointerstitial fibrosis and able to preserve kidney function are needed. Vasoactive intestinal peptide (VIP) has been shown to reverse pre-existing cardiac fibrosis. We sought to determine whether VIP is effective in tubulointerstitial fibrosis. Spontaneous hypertensive rats (SHR) on a 2.2% salt diet were randomised to zero time control, 4 week infusion of VIP (5 pmol/kg/min) or vehicle control infusion. A fourth group, to match the blood pressure reduction achieved in the VIP infused group was included. Fibrosis was quantitated by computerised histomorphometry, changes in pro-fibrotic mediators were measured by quantitative rt-PCR and macrophage activation assessed by cyclic adenosine monophosphate (c-AMP) response to incubation with VIP. Tubulointerstitial fibrosis in the VIP treated rats was significantly lower than the zero time control (P < 0.0005), the vehicle infused control (P < 0.0005) and the blood pressure matched group (P < 0.01). Although all six profibrotic mediators increased over the 4 week experimental period VIP infusion only decreased tumour necrosis alpha (TNFα) expression significantly (P < 0.001). Incubation of RAW264 macrophages with VIP significantly increased c-AMP (P < 0.01). We conclude that VIP infusion reversed existing tubulointerstitial fibrosis suggesting a possible therapeutic role for a VIP based therapy in chronic kidney disease.

  PublisherDOI

• Vasoactive intestinal peptide infusion reverses existing myocardial fibrosis in the rat

  European Journal of Pharmacology · 2019-08-23 · 15 citations

  articleOpen access

  Congestive cardiac failure has become one of the major health challenges of the 21st century and new therapies are needed to address this problem. The concentration of vasoactive intestinal peptide (VIP) in the heart has been shown to decrease as fibrosis (the pathology leading to heart failure) increases and to become undetectable in end stage cardiomyopathy. We sought to determine whether replenishment of myocardial VIP might treat myocardial fibrosis and therefore represent a new therapeutic target. Wistar Kyoto rats on a high (4.4%) salt diet were randomised to zero time control, 4 week infusion of VIP (5 pmol/kg/min) or vehicle control infusion. Myocardial VIP concentration was measured by radioimmunoassay, fibrosis was quantitated by computerised histomorphometry and changes in pro-fibrotic mediators were measured by quantitative rt-PCR. Myocardial VIP increased significantly in VIP treated rats compared with vehicle treated controls (P < 0.01) while fibrosis in the VIP treated rats was significantly lower than in both the zero time control (P < 0.05) and the vehicle infused control (P < 0.0005). Although all six profibrotic mediators which were measured increased over the 4 week experimental period VIP infusion only affected angiotensinogen (Agt) and angiotensin receptor type 1a (AT1a) expression. In both instances VIP caused a significant decrease in messenger rna expression (Agt P < 0.01 and At1a P < 0.01) compared with vehicle infused controls. We conclude that VIP infusion increased myocardial VIP concentration and was able to reverse existing myocardial fibrosis suggesting a possible therapeutic role for a VIP based therapy in cardiac failure.

  PublisherDOI

• Improving Traffic Safety Through Video Analysis in Jakarta, Indonesia

  Advances in intelligent systems and computing · 2019-08-23 · 3 citations

  book-chapterOpen access
  PublisherOA PDFDOI

• Application of the Internet of Things in the textile industry

  Textile Progress · 2019-07-03 · 68 citations

  article

  The ‘Internet of Things’ (IoT) is at times mythologized and its purpose mistaken, and often people can become confused about what it means, does or aims to achieve; moreover, without a financial appraisal of the differences IoT can make to their own enterprise, business leaders may be content to watch and wait rather than to take a lead. This issue of Textile Progress aims to provide a guide to help navigation beyond general statements about IoT and to help those involved with the textile industry to make an informed decision about its potential value to them. The definitions of the Internet of Things (IoT) available in the literature, and those put forth by organizations working on IoT standards development, are reviewed along with its architecture, elements, standards and protocols to help provide an understanding of the concepts and goals of IoT. A broad overview of impediments challenging the progress of IoT, especially in relation to cybersecurity, is provided. This review also compares ongoing work in the application of IoT in the textile industry to that in other manufacturing sectors whilst focussing on the interpretation of IoT technologies and their potential application to the textile industry according to both technological and business perspectives. A specific case study for the spinning industry is conducted to help with evaluation of its IoT solutions and to help to address how other parts of the textile industry might benefit from its application. The case study includes evaluation of IoT solutions in the spinning industry spanning the period between ITMA 2011 to 2019, and takes information from interviews with industry executives to inform future directions of IoT in the spinning industry.

  PublisherDOI

• THE EFFECT OF SIMPLE ROLE-PLAYING GAMES ON THE WARGAMING STEP OF THE MILITARY DECISION MAKING PROCESS (MDMP): A MIXED METHODS APPROACH

  2018-03-14

  article

  Researchers at the Command and General Staff College (CGSC) conducted a mixed methods examination of the effect playing simple role playing board games might have on participants planning skills.  The literature examined for this study established that one of the weaknesses reported over the last twenty years at combat training centers was the ability to conduct an effective wargame to stress test plans.  Therefore, the purpose of this study was to measure participant’s ability to visualize and apply that visualization to the wargaming step of the Military Decision Making Process (MDMP).  The test group consisted of 32 students with a control group of 79 totaling 111 participants.  The Test Group played a simple roleplaying board game called Kriegspeil while the control group did not.  Researchers measured visualization skills using a quiz designed to measure participant recall skills and comfort making choices based on their visualization; the Wargames were observed to establish the number and quality of discovered planning shortfalls.  Findings established to a statistically significant level that the test outperformed the control group at seeing themselves, being comfortable making visualization choices, while seizing opportunities and addressing threats integrating discoveries into plans.  These findings may be applicable not only to the military but to other contexts where leaders endeavor to anticipate the unexpected emerging threats and opportunities that may arise in dynamic environments.

• A simple, accurate and universal method for quantification of PCR

  BMC Biotechnology · 2016-03-08 · 68 citations

  articleOpen access

  BACKGROUND: Research into gene expression enables scientists to decipher the complex regulatory networks that control fundamental biological processes. Quantitative real-time PCR (qPCR) is a powerful and ubiquitous method for interrogation of gene expression. Accurate quantification is essential for correct interpretation of qPCR data. However, conventional relative and absolute quantification methodologies often give erroneous results or are laborious to perform. To overcome these failings, we developed an accurate, simple to use, universal calibrator, AccuCal. RESULTS: Herein, we show that AccuCal quantification can be used with either dye- or probe-based detection methods and is accurate over a dynamic range of ≥10(5) copies, for amplicons up to 500 base pairs (bp). By providing absolute quantification of all genes of interest, AccuCal exposes, and circumvents, the well-known biases of qPCR, thus allowing objective experimental conclusions to be drawn. CONCLUSION: We propose that AccuCal supersedes the traditional quantification methods of PCR.

  PublisherOA PDFDOI

• Additional file 1: of A simple, accurate and universal method for quantification of PCR

  Figshare · 2016-01-01

  datasetOpen access

  Supporting data for Figs 1-4. (XLS 603Â kb)

  PublisherDOI

• Vendor-managed inventory systems in the apparel industry

  Elsevier eBooks · 2016-01-01 · 2 citations

  book-chapterSenior author
  PublisherDOI

• Haze Gazer: A Crisis Analysis And Visualisation Tool To Better Inform Peatland Fire And Haze Management

  Zenodo (CERN European Organization for Nuclear Research) · 2016-09-15 · 1 citations

  articleOpen access

  Peatland fires and haze events in Indonesia are disasters with national and international implications. The phenomena lead to direct damage to local assets, as well as broader economic, social and environmental losses. Despite the extensive efforts of many organizations, the situation persists. At present, Indonesian disaster management authorities manage peatland fire and haze events based on satellite data as well as static data on population density and distribution. But to better support affected populations, the Government is looking for more timely data and more information on the dynamics of the disaster, especially the situation on the ground. Pulse Lab Jakarta’s Haze Gazer enhances disaster risk management efforts by providing real-time situational information from diverse data sources, including insights on the response strategies of haze-affected communities, in order to better protect vulnerable populations and the environment.

  PublisherDOI

• How Can We Do Better? Improving Performance in Global Textile and Apparel Supply Chains

  2013-01-01

  reportOpen accessSenior author

  In apparel manufacturing facilities in developing countries, experts can often be observed conducting time studies on sewing specialists, with the goal of increasing productivity by decreasing cycle times. Many companies in developing countries are attempting to increase performance by concentrating on productivity improvements (Bheda, 2002; Bheda, 2003; Joint Apparel Association Forum, 2007).

  PublisherOA PDFDOI

Frequent coauthors

• William Oxenham

  14 shared

• Karen Duggan

  Beaumont Hospital

  10 shared

• Abdel‐Fattah M. Seyam

  North Carolina State University

  9 shared

• Katherine A. Duggan

  University of Pittsburgh

  7 shared

• E. Grant

  Alton Community Hospital

  6 shared

• MM Makarious

  Liverpool Hospital

  6 shared

• Tegan Hunter

  5 shared

• Victor Z.C. Ye

  UNSW Sydney

  5 shared

Labs

• Textiles ComplexPI

Awards & honors

• 2002 NCSU Libraries Faculty Award
• 1994 Outstanding Teacher of the Year