Gwaudar Chen
VerifiedUniversity of Arizona · Software Engineering
Active 1991–2024
Research topics
- Evolutionary biology
- Genetics
- Biology
- Medicine
- Demography
- Internal medicine
- Bioinformatics
- Endocrinology
- Computational biology
Selected publications
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Nature · 2024 · 480 citations
- Biology
- Genetics
- Evolutionary biology
in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.
Nature Genetics · 2022 · 724 citations
- Biology
- Genetics
- Evolutionary biology
Frequent coauthors
- 291 shared
Adebowale Adeyemo
National Human Genome Research Institute
- 247 shared
Charles N. Rotimi
National Human Genome Research Institute
- 215 shared
Jie Zhou
Xuzhou Medical College
- 171 shared
Ayo P. Doumatey
National Institutes of Health
- 143 shared
Daniel Shriner
National Institutes of Health
- 123 shared
Amy R. Bentley
National Institutes of Health
- 94 shared
Kofi Agyenim‐Boateng
Kwame Nkrumah University of Science and Technology
- 94 shared
O.A Fasanmade
University of Lagos
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