About

David Anderson is a Professor in the Department of Mathematics at The Ohio State University. He holds a PhD from the University of Michigan, obtained in 2009. His areas of expertise include Algebraic Geometry and Combinatorics. His research focuses on these fields, contributing to the mathematical community through his academic work and teaching. He is based at the Columbus campus, with office location MW 602, 231 W. 18th Ave., Columbus, OH 43210. His contact email is anderson.2804@osu.edu, and he can be reached by phone at (614) 292-5754.

Research topics

• Computer Science

Selected publications

• Mesenchymal Stem Cell Secretome in Tendon Regeneration: Therapeutic Potential, Mechanisms of Action, and Future Perspectives

  Cells · 2026-04-30

  articleOpen accessSenior author

  Tendon injuries are common and debilitating musculoskeletal conditions that impose pain and debilitation to patients, significant challenges to medical professionals, and financial burdens to the healthcare system. Due to limited natural healing capacity, tendons typically undergo scar-mediated repair that compromises biomechanical integrity and increases the risk of reinjury. Despite a variety of therapeutic strategies, functional tendon healing remains a major clinical challenge. Mesenchymal stem cells (MSCs) represent an attractive strategy to improve tendon healing, largely due to their immunomodulatory and regenerative properties. Increasing evidence suggests that the therapeutic potential of MSCs is primarily attributed to their paracrine activity via the release of the secretome, a set of bioactive molecules that are known to mimic the immunomodulatory and regenerative properties of their parental cells. More recently, acellular approaches using MSC secretome derivatives, such as conditioned media and extracellular vesicles, have been largely explored for tendon healing. This review of the literature explores the therapeutic potential of MSC secretome derivatives for tendon healing, highlighting their advantages over cell-based therapies, proposed mechanisms of action, manufacturing and scalability considerations, and current state of research.

  PublisherDOI

• Degenerative Gastrocnemius Muscle Changes in a Goat Tibial Ostectomy Model Persist 10 Months After Splint Removal

  Muscles · 2026-03-04

  articleOpen access

  Major orthopedic limb surgery is often accompanied by external coaptation; the combined effect of these interventions can lead to muscle atrophy and functional impairment. Large animal models, including goats, are commonly used to study orthopedic interventions, yet longitudinal data on muscle changes after such interventions are limited. This study quantified gastrocnemius muscle adaptations in adult Boer-cross goats undergoing a clinically representative unilateral tibial segmental ostectomy and external coaptation protocol. Muscles on the operated side exhibited statistically significant decreases in mass, length, optimal fiber length, and CSA, and increases in nucleus density compared to muscles on the contralateral, non-operated side (p < 0.05). Although muscle properties showed partial recovery over time, mass and CSA remained 20–30% lower on the operated side than on the non-operated side at 12 months post-surgery despite cast removal at about 2 months post-surgery. Muscle CSA was positively correlated with bone mineral density and peak vertical ground reaction forces measured during the in vivo study. The extent of muscle recovery in the goat model was less than that observed for other mammalian models of hindlimb remobilization. More research is needed to understand the complex interaction between surgery, external coaptation, and muscle properties in the goat model.

  PublisherOA PDFDOI

• Effect of suture anchor type, eyelet configuration, and loading condition on suture failure: An in vitro study

  Veterinary Surgery · 2025-02-24

  articleOpen access

  Abstract Objective To determine the effect of suture anchor type, eyelet configuration (raised or embedded), and loading condition (without or with cyclic loading) on failure load and failure mode of sutures in anchors with embedded and raised eyelets. Study design Controlled laboratory study. Sample population A total of 4 unique clinical anchor+suture combinations ( n = 40 total); eyebolt screw reference samples ( n = 30 total). Methods A total of 10 samples of each anchor+suture combination were either (a) loaded to failure ( n = 5) or (b) loaded from 0 N to 60 N for 1000 cycles then loaded to failure ( n = 5). As a “best‐case” reference, an eyebolt screw with a smooth, round cross‐section was tested under the same two loading conditions and the same sutures ( n = 10 per suture) used with the clinical anchors. The percent difference in the maximum load at failure () between each anchor and suture‐matched eyebolt screw was used to quantify the effect of each anchor on suture strength. Results There was no effect of loading condition (i.e., without or with cyclic loading) on F max . The Anika anchor had a significantly lower than the Arthrex anchor ( p = .015), IMEX anchor ( p = .004) and Jorvet anchor ( p < .001). A total of 14 out of 20 samples of anchors with raised eyelets failed at the suture mid‐section, whereas all 20 samples of anchors with embedded eyelets failed at the suture knot. Conclusion Anchors with raised eyelets had more failures at the suture mid‐section indicative of wear and/or cutting of the suture against the eyelet. Clinical significance Eyelet geometry and surface finish of metallic screw‐type anchors have effects on suture strength.

  PublisherOA PDFDOI

• Parliament And The Rule Of Law

  SSRN Electronic Journal · 2025-01-01

  preprintOpen access1st authorCorresponding
  PublisherDOI

• Anesthesia and Surgical Procedures in Swine

  2025-07-23

  other1st authorCorresponding
  PublisherDOI

• The Impact of the European Convention on Human Rights on UK National Security

  The European Convention on Human Rights Law Review · 2025-05-20

  articleOpen access1st authorCorresponding

  Half a century ago, the law of England and Wales in relation to issues of national

  PublisherOA PDFDOI

• Synthesis and Structure of Neopentyl Sodium: A Hydrocarbon‐Soluble Reagent for Controlled Sodiation of Non‐Activated Substrates

  Angewandte Chemie · 2025-07-29

  articleOpen access1st author

  Abstract While recent studies have shown that organosodium reagents can offer excellent promise in organic synthesis, their widespread applications can be hindered by their limited solubility in organic solvents, lack of stability, and uncontrolled reactivity. Improving this immature area, here we report the structure of unsolvated neopentyl sodium, which exhibits a unique discrete tetrameric motif and good solubility in hexane. Combining spectroscopic and crystallographic studies with computational bonding analysis, key insights into its constitution and stability have been gained. Expanding its synthetic potential, supporting neopentyl sodium with Lewis donor PMDETA ( N,N,N′,N″,N″ ‐pentamethyldiethylenetriamine) allows for the direct metalation of challenging non‐activated arenes and alkenes, including the regioselective meta ‐functionalisation of selected 1,3‐disubstituted alkyl arenes. Shedding light on sodium‐mediated metalation protocols, key organometallic intermediates have been isolated and structurally defined, which can subsequently be intercepted with CO 2 or a boron electrophile to be directly used in Pd‐catalysed Suzuki cross coupling reactions.

  PublisherDOI

• Performance improvements and increased ruminal microbial interactions in Angus heifers via supplementation with native rumen bacteria during high-grain challenge

  Scientific Reports · 2025-01-17 · 3 citations

  articleOpen access

  Feedlot cattle may be subjected to digestive disorders, including ruminal acidosis, due to high concentration of grain in their diet. Therefore, novel feeding strategies are required to maximize animal performance and mitigate economic losses in the operation. This study employed a two-period crossover design to assess the effect of direct ruminal administration of native rumen microorganisms (NRM) inoculation on cattle that underwent a high-grain challenge. The NRM inoculation consisted of six microorganisms (1.70 M CFU /day/animal) isolated from the rumen of healthy feedlot cattle: Succinivibrio dextrinosolvens ASCUSBF53, Prevotella albensis ASCUSBF41, Chordicoccus furentiruminis ASCUSBF65, Bacteroides xylanisolvens ASCUSBF52, Clostridium beijerinckii ASCUSBF26, and Syntrophococcus sp. ASCUSBF60. The trial consisted of 16 Angus heifers receiving NRM (n = 8) or a CON (CON = Carrier Buffer; n = 8) inoculation daily for 14-days as pre-challenge while on a high-grain diet and continued daily for a 21-day treatment period. The combined 35 days of microbial supplementation resulted in an improved average daily gain (ADG) of 29% (P = 0.037) and a tendency toward a 19% decrease in the feed efficiency metric, gain to feed ratio (G: F) (P = 0.055). Additionally, administration of NRM to animals on a high-grain diet, improved ruminal microbiome stability (P < 0.001), potentially encouraging the conversion of rumen lactate to propionate over time via the succinate pathway and alleviating metabolic stress.

  PublisherOA PDFDOI

• Attaching artificial Achilles and tibialis cranialis tendons to bone using suture anchors in a rabbit model: assessment of outcomes

  PeerJ · 2025-01-21 · 2 citations

  articleOpen access

  Objective The purpose of this study was to investigate the timing and mode of failure of metallic screw-type suture anchors used to attach artificial tendons to bone in an in vivo New Zealand White rabbit model. Study Design Metal suture anchors with braided composite sutures of varying sizes (United States Pharmacopeia (USP) size 1, 2, or 5) were used to secure artificial tendons replacing both the Achilles and tibialis cranialis tendons in 12 female New Zealand White rabbits. Artificial tendons were implanted either at the time of (immediate replacement, n = 8), or four/five weeks after (delayed replacement, n = 4) resection of the biological tendon. Hindlimb radiographs of the rabbits were obtained immediately after surgery and approximately every other week until the study endpoint (16 weeks post-surgery). Results All suture anchors used for the tibialis cranialis artificial tendons remained secure and did not fail during the study. The suture anchor used to attach the Achilles artificial tendon to the calcaneus bone failed in nine of 12 rabbits. In all cases of suture anchor failure, the suture broke away from the knot, while the metallic screw remained securely embedded in the bone. Based on radiographic analysis, the mean estimated failure timepoint was 5.3 ± 2.3 weeks post-surgery, with a range of 2–10 weeks. Statistical analyses (Mann–Whitney U test and Fisher’s exact test) revealed no significant effect of tendon implantation timing or suture size on either the timing or frequency of suture anchor failure. Conclusion For the suture anchors used to attach artificial tendons in this study, suture anchor failure was most likely due to suture wear or cutting against the eyelet of the anchor screw. Future studies are needed to test the effect of suture-eyelet interaction on suture strength under different loading conditions.

  PublisherDOI

• 3D-Printed Poly (Lactic-Co-Glycolic Acid) and Graphene Oxide Nerve Guidance Conduit with Mesenchymal Stem Cells for Effective Axon Regeneration in a Rat Sciatic Nerve Defect Model

  International Journal of Nanomedicine · 2025-03-01 · 7 citations

  articleOpen access

  Introduction: Peripheral nerve injuries (PNIs) impact the quality of life of millions of people. The current gold standard of treatment, the autograft, fails to restore nerve function and is often associated with untoward effects. The alternative interventions available remain unable to ensure full functional recovery. For this study we developed a 3D printed nerve guidance conduit (NGC) composed of poly (lactic-co-glycolic acid) (PLGA) and 0.25% graphene oxide (GO), that can be seeded with human adipose-derived mesenchymal stem cells (MSCs), to develop a more effective treatment for PNI. Methods: MSCs. For a 6-month period: biomechanics were evaluated using a pressure mat walkway to determine functional repair; systemic toxicity was evaluated using transmission electron microscopy of kidney and lung tissue; immunohistochemistry evaluated local adverse effects, myelin sheath and axonal repair; and gross muscle analyses of the lateral gastrocnemius, medial gastrocnemius, and soleus evaluated muscle reinnervation. Results: In vitro results showed expected degradation rates, and the addition of GO exhibited cytocompatibility and favorable cell attachment. In vivo results showed biocompatibility with no translocation of the graphene nanoparticles. Histology showed evidence of axonal and myelin sheath repair. Biomechanics and gross muscle analyses had contradicting evidence of functional repair with the addition of GO. No differences were seen with the addition of MSCs. Conclusion: Our novel PLGA/GO NGC, both with and without MSCs, showed results comparable to or greater than the current gold standard, as well as ease of use surgically. With further studies to validate functional recovery, this specific combination of PLGA and GO may provide an effective biomimetic therapy to repair PNIs.

  PublisherOA PDFDOI

Recent grants

• NIH Grant Z01AG000600

  NIH · $282k

• NIH Grant R01CA040173

  NIH · $561k · 1992

• NIH Grant R01HL028462

  NIH · $56k · 1987

• NIH Grant ZIAAG000600

  NIH · $446k

• Degeneracy loci, toric degenerations, and equivariant algebraic geometry

  NSF · $130k · 2015–2019

Frequent coauthors

• Jos A. Bosch

  171 shared

• Nicolas Rohleder

  Friedrich-Alexander-Universität Erlangen-Nürnberg

  128 shared

• Yoshiyuki Takimoto

  The University of Tokyo

  128 shared

• Shin Fukudo

  Tohoku University

  128 shared

• Holly Rau

  VA Puget Sound Health Care System

  126 shared

• Paula Williams

  PTC Therapeutics (United States)

  124 shared

• J. Rick Turner

  IQVIA (United States)

  120 shared

• David A. Hafler

  Broad Institute

  91 shared

Education

• MS - Clinical Science (Orthopedics)

  Kansas State University

  1994

• Diplomate, American College of Veterinary Surgeons, Clinical Sciences

  Kansas State University

  1994

• DVM

  North Carolina State University

  1990

• BS - Animal Science

  North Carolina State University

  1988

Awards & honors

• Graduate Teaching Awards