About

Dr. Gabriela Seiler received her Doctor of Veterinary Medicine degree from the University of Bern, Switzerland, and worked in small animal practice there for two years while performing a doctoral thesis. She entered a radiology residency program at the University of Bern and became board certified in radiology by the European College of Veterinary Diagnostic Imaging in 2001. After serving as a Lecturer in Radiology, she became an Assistant Professor of Radiology at the University of Pennsylvania in 2004 and completed board certification by the American College of Veterinary Radiology in 2006. In 2009, she joined North Carolina State University as an Associate Professor with a tenure track, and was promoted to Professor in 2017. Her main research focus is on the use of advanced ultrasound imaging methods in veterinary and translational medicine, with a special interest in tumor perfusion. She investigates blood supply of tumors to characterize tumor types, select optimal treatments, and assess responses, emphasizing the relevance of cancer research in dogs and cats to human patients due to the spontaneous nature and size of these animals. Her work includes the application of contrast-enhanced ultrasound, a safe and non-invasive imaging method, to evaluate organ perfusion and tumor characteristics, and explores its potential for targeted therapy and gene delivery. Dr. Seiler's contributions extend to clinical studies on feline chronic kidney disease and gallbladder mucocele formation in dogs, aiming to understand disease mechanisms and develop rational treatment strategies.

Research topics

• Medicine
• Pathology
• Radiology
• Microbiology
• Immunology
• Medical physics
• Gastroenterology
• Biology
• Anatomy
• Internal medicine
• General surgery
• Law

Selected publications

• Furosemide Administration Enhances Diagnostic Confidence in the Evaluation of Ureteral Ectopia in Dogs Using Ultrasound

  Veterinary Radiology & Ultrasound · 2026-05-01

  article

  Ultrasonography is frequently utilized in patients with urinary incontinence to screen for structural abnormalities such as ectopic ureters (EUs). Furosemide can be administered during an ultrasound for a better assessment of the ureters and their insertions. Furosemide decreases urine specific gravity (USG), and differences in specific gravity allow a better visibility of ureteral jets on ultrasound; however, it is unknown whether furosemide has utility in patients with hyposthenuria or isosthenuria. The aims of this study were to determine if furosemide administration improves the diagnosis of EUs using ultrasound and if there is a USG below which furosemide will not increase ureteral jet visibility. Thirty-one dogs with clinical suspicion for EUs, and seven dogs with polyuria and polydipsia were included. Urinary tract ultrasonography was performed, and a diagnosis of the presence or absence of EUs was made. Urine collected by urocystocentesis was used to measure USG, furosemide was administered, and the exam was repeated. Ultrasound results were compared to cystoscopy or other means of negative diagnosis to determine accuracy. The accuracy of the EU diagnosis following furosemide was not statistically significant. There was a significant increase in the confidence of diagnosis post-furosemide; there was no association between increased confidence and improved accuracy. Ureteral jets were visible following furosemide in dogs with USGs as low as 1.006. On the basis of these findings, furosemide can be helpful to improve confidence of EU diagnosis and can be administered to increase ureteral jet visibility in dogs with hyposthenuria or isosthenuria.

  PublisherDOI

• Canine and Feline Pleural Space

  Elsevier eBooks · 2025-04-11

  book-chapter1st authorCorresponding
  PublisherDOI

• Diagnosis and management of gallbladder mucocele formation in dogs

  Journal of the American Veterinary Medical Association · 2025-03-19 · 7 citations

  reviewOpen accessSenior author

  The past 20 years have observed the emergence of an enigmatic and deadly disease in dogs referred to as gallbladder mucocele formation. The disease has been the subject of over 100 PubMed-indexed publications, yet only a single review of the topic has been published approximately 10 years ago. The aim of the current review was to provide a practical overview of the current literature of and, in some cases, the authors' experience in the diagnosis and management of gallbladder mucocele formation in dogs. Key takeaways were that gallbladder mucocele formation is caused by secretion of abnormal mucus by the gallbladder epithelium and has a predilection for older, small-sized purebred dogs. These dogs are often concurrently diagnosed with hypothyroidism, hyperadrenocorticism, hyperlipidemia, and proteinuria. Diagnosis is reliant on ultrasonographic features demonstrating the presence of non-gravity-dependent mucus that is adherent to the walls of the gallbladder and encroaching into the lumen. The definitive treatment for mucocele formation is cholecystectomy, which carries a significant short-term mortality but good long-term prognosis.

  PublisherOA PDFDOI

• Fracture Healing and Complications

  Elsevier eBooks · 2025-04-11

  book-chapter1st authorCorresponding
  PublisherDOI

• Magnetic Resonance Imaging and Computed Tomographic Features of Brain Disease in Small Animals

  Elsevier eBooks · 2025-04-11 · 1 citations

  book-chapterSenior author
  PublisherDOI

• Canine and Feline Thoracic Wall

  Elsevier eBooks · 2025-04-11

  book-chapter1st authorCorresponding
  PublisherDOI

• Dose-dependent safety and renal ultrasound contrast kinetics of oxygen microbubbles in healthy dogs

  The Journal of the Acoustical Society of America · 2025-04-01

  article

  Oxygen microbubbles (OMB) are lipid-shelled ultrasound contrast agents with an oxygen gas core that show promise as theranostic agents for diagnostic imaging and enhancing radiotherapy efficacy in preclinical rodent models. By improving oxygenation in hypoxic tumor regions, OMBs may increase radiosensitivity. However, their safety, tolerability, and potential to act as vascular imaging contrast agents have yet to be assessed in larger animals. In this study, four healthy beagle dogs received intravenous OMBs at escalating doses 1, 10, and 100 μl/kg at 1-week intervals. Over a 4-week observation period, key physiological parameters, including temperature, pulse, and respiration, were monitored alongside complete blood counts, blood biochemistry, coagulation panels, and urinalysis. Additionally, the ability of OMBs to enhance contrast during kidney ultrasound imaging was evaluated, and pharmacokinetic parameters were estimated. Across all doses, OMB administration was well tolerated, with no clinically significant changes in vital signs or laboratory values. Ultrasound imaging revealed dose-dependent increases in renal contrast enhancement. Pharmacokinetic analyses confirmed that higher doses prolonged contrast enhancement and improved image quality. This study provides an initial safety and diagnostic benchmark for OMB administration in dogs, laying the groundwork for future investigations into their theranostic potential.

  PublisherDOI

• Kidneys and Ureters

  Elsevier eBooks · 2025-04-11

  book-chapter1st authorCorresponding
  PublisherDOI

• List of Contributors

  Elsevier eBooks · 2025-04-11

  book-chapter
  PublisherDOI

• Basics of thoracic ultrasonography

  British Small Animal Veterinary Association eBooks · 2024-01-01

  book-chapter1st authorCorresponding

  Thoracic ultrasonography serves as a complementary imaging technique to radiography for assessment of non-air-filled structures. This chapter covers the myriad ultrasonographic views used in echocardiography, explaining the acquisition of each view as well as observations and measurements of interest, accompanied by examples of normal and pathological appearance. Additionally, assessments of cardiac structure, function and blood flow enabled by Doppler ultrasonography are discussed. The chapter also provides an overview of non-cardiac thoracic ultrasonography, including patient preparation, equipment selection and techniques for image acquisition.

  PublisherDOI

Frequent coauthors

• Wilfried Maï

  60 shared

• Jeremy D. Hubert

  Colorado State University

  49 shared

• Margaret C. Mudge

  The Ohio State University

  49 shared

• Sarah Dukti

  49 shared

• David M. Bolt

  Royal Veterinary College

  49 shared

• Franz E. Weber

  University of Zurich

  26 shared

• Jason C. Schense

  26 shared

• Jeffrey A. Hubbell

  University of Chicago

  26 shared

Labs

• CVM Radiology LabPI

Awards & honors

• Diplomate, European College of Veterinary Diagnostic Imaging
• Diplomate, American College of Veterinary Radiology