Bruce Joseph Giantonio
University of Pennsylvania · Rehabilitation Medicine
Active 1994–2023
Research topics
- Gastroenterology
- Biology
- Oncology
- Internal medicine
- Medicine
Selected publications
Clinical Cancer Research · 2021 · 347 citations
- Medicine
- Internal medicine
- Oncology
PURPOSE: Detection of persistent circulating tumor DNA (ctDNA) after curative-intent surgery can identify patients with minimal residual disease (MRD) who will ultimately recur. Most ctDNA MRD assays require tumor sequencing to identify tumor-derived mutations to facilitate ctDNA detection, requiring tumor and blood. We evaluated a plasma-only ctDNA assay integrating genomic and epigenomic cancer signatures to enable tumor-uninformed MRD detection. EXPERIMENTAL DESIGN: A total of 252 prospective serial plasma specimens from 103 patients with colorectal cancer undergoing curative-intent surgery were analyzed and correlated with recurrence. RESULTS: = 0.18); PPV = 53.9%]. CONCLUSIONS: .
Frequent coauthors
- 301 shared
Neal J. Meropol
Case Western Reserve University
- 286 shared
Paul J. Catalano
- 283 shared
Al B. Benson
Northwestern University
- 275 shared
Peter J. O’Dwyer
University of Pennsylvania
- 127 shared
Edith P. Mitchell
- 99 shared
Steven R. Alberts
Mayo Clinic
- 98 shared
Michael Schwartz
- 89 shared
Steven J. Harper
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