About

Martin Rosenthal, MD, FACS, is a faculty member associated with UF Health. The provided page text does not include specific details about his research focus, background, or key contributions. Therefore, a detailed professional biography cannot be generated from the available information.

Research topics

• Medicine
• Pathology
• Intensive care medicine
• Emergency medicine
• Environmental health
• Family medicine
• Internal medicine
• Medical emergency
• Surgery

Selected publications

• Persistent inflammation, immunosuppression, and catabolic syndrome: A new look at a growing problem

  Nutrition in Clinical Practice · 2026-02-17

  articleSenior authorCorresponding

  Nutrition support among critically ill patients in the intensive care unit remains a cornerstone to standard-of-care strategies. Clinicians rely on a robust body of literature, societal guidelines and recommendations, evidence-based protocols, and more to aid in the appropriate delivery of nutrients to this patient population. Among critically ill patients, there is a growing population of patients with smoldering multiorgan dysfunction (MOD) known as persistent inflammation, immunosuppression, and catabolic syndrome (PICS-1). The growth of this patient population is likely related not only to increasing awareness of chronic critically ill patients but also has evolved as intensive care management has improved following the development of bundles, protocols, evidence-based practice, and multidisciplinary care teams. PICS-1 is being recognized more frequently as these patients have survived and can be salvaged from MOD. Unfortunately, there is no evidence regarding nutrition support for these patients (other than inferences from other bodies of literature). This review will serve to describe the origins, a brief epidemiologic discussion, and potential nutrition supplements that may impact the clinical outcomes of PICS-1.

  PublisherDOI

• 470: ENERGY REQUIREMENTS IN VENTILATED SURGICAL-TRAUMA CRITICALLY ILL PATIENTS WITH ACUTE KIDNEY INJURY

  Critical Care Medicine · 2025-01-01

  articleSenior author
  PublisherDOI

• 443: PROVISION OF LOW VERSUS HIGH PROTEIN IN CRITICALLY ILL SURGICAL AND TRAUMA PATIENTS

  Critical Care Medicine · 2025-01-01

  article
  PublisherDOI

• Using the quality enhancement research initiative framework for implementation science in clinical nutrition

  Nutrition in Clinical Practice · 2025-10-26

  articleSenior author

  Implementation science (IS) offers a structured approach to bridging the gap between research and practice by facilitating the adoption of evidence-based interventions (EBIs). One established framework within IS is the Quality Enhancement Research Initiative (QUERI), developed by the US Department of Veterans Affairs. QUERI promotes the active dissemination of EBIs through a phased roadmap: preimplementation (data to knowledge), implementation (knowledge to performance), and sustainment (performance to data). This review article explores the QUERI framework in depth and its application in clinical nutrition settings. Two case studies illustrate how QUERI can enhance implementation efforts: (1) improving inpatient malnutrition screening and (2) integrating outpatient surgical prehabilitation programs. In the first case, QUERI guides the identification of low screening and diagnosis rates, stakeholder engagement, toolkit development, and ongoing evaluation to ensure sustainability. In the second, QUERI aids in developing and adapting evidence-based prehabilitation protocols while balancing fidelity and customization to local workflows. Both examples demonstrate the importance of structured planning, stakeholder involvement, and iterative evaluation in achieving sustained change. QUERI's emphasis on choosing a high-volume or high-risk problem, defining best practices, and documenting outcomes makes it a valuable tool for nutrition professionals aiming to improve outcomes through consistent application of EBIs. As clinical nutrition continues to evolve, implementation frameworks like QUERI offer a practical pathway for translating research into impactful, sustainable improvements in patient care.

  PublisherDOI

• Roles, responsibilities, and opportunities for the nutrition support physician working with adults: A critical review

  Journal of Parenteral and Enteral Nutrition · 2025-07-02 · 1 citations

  review

  The dual burden of undernutrition and overnutrition requires a greater understanding and commitment to physician training and specialization in nutrition support. Despite the significant healthcare need and existence of organizations focused on nutrition support such as the American Society for Parenteral and Enteral Nutrition (ASPEN), physician involvement in the nutrition care of high-risk patients remains low. In an ASPEN survey of members, inadequate training among physicians was reported along with significant barriers to involvement in nutrition support, such as insufficient protected time, reduced reimbursement and financial support, inadequate support from administrators or supervisors, as well as a nationwide reduction in number of nutrition support teams. These changes in the healthcare landscape prompted the ASPEN Physician Engagement Committee to develop a critical review focused on domains of nutrition risk assessment, enteral and parenteral access and support, scholarly activities, board certification, administrative responsibilities, education and training opportunities, coding, and reimbursement. The aim of this critical review is to capacitate physicians to engage in nutrition support and enhance their acumen in clinical nutrition to improve patient care and enrich personal and professional development.

  PublisherDOI

• Lipids in parenteral nutrition – expert consensus statements: Translating guidelines into clinical practice

  Clinical Nutrition Open Science · 2025-01-21 · 7 citations

  articleOpen access

  <h2>Summary</h2> Lipids are integral to parenteral nutrition (PN) in all settings where PN is required, serving as a source of energy and essential fatty acids. In addition, lipids modulate a variety of biological functions, including inflammatory and immune responses. Moreover, fish oil (FO), which contains omega-3 fatty acids, has become an important component of modern lipid emulsions. The Lipids in PN Summit involved a panel of international experts with extensive clinical experience in PN use. They assessed the current state of knowledge and developed expert consensus statements regarding the use of lipid emulsions in patients requiring PN. This summit built upon outcomes from an earlier summit, and focused on adult patients in three distinct clinical settings: intensive care units, hospital wards, and the home environment/long-term PN. The summit workflow included identification and appraisal of scientific and clinical literature, the exchange of practical clinical experience, and the formulation of consensus statements. The latter aim to assist healthcare professionals in their decision-making processes in daily practice by providing practical guidance related to providing lipid emulsions as part of PN. This article briefly summarizes the biological effects of lipids used in PN, and then focuses on the rationale for their use in three distinct adult PN settings. Expert consensus statements are also provided, helping to bridge gaps between evidence and clinical practice, and thus complementing formal PN guideline recommendations. There is accumulating evidence suggesting that PN including FO confers clinically meaningful advantages compared with PN without FO, and has a favorable risk–benefit ratio.

  PublisherOA PDFDOI

• Parenteral Nutrition Containing Fish Oil for Hospitalized Non-Intensive Care Unit (ICU) Patients: A Systematic Review, Meta-Analysis, and Cost-Effectiveness Analysis

  Nutrients · 2025-04-07 · 3 citations

  reviewOpen access

  Background and aims: We investigated parenteral nutrition (PN) containing fish oil (FO-PN) vs. standard PN without fish oil (NF-PN) in adult patients hospitalized in the non-intensive care unit (general ward). Methods: Searches in Medline, Embase, and Web of Science (any date to 10 October 2024) were screened, data were extracted, and the quality of the studies was assessed by two independent researchers. Meta-analyses were performed, with outcomes included in random effects models, and heterogeneity for clinical outcomes was explored via subgroup analyses and meta-regression. Pharmacoeconomic analyses used data from the current meta-analysis. Results: In this study, 29 randomized controlled trials (RCTs) were included, with intervention and control groups given FO-PN and NF-PN, respectively, as part of PN covering ≥70% energy provision. Compared to NF-PN, FO-PN was associated with a 37% lower relative risk (RR) of infection (19 RCTs; RR 0.63, 95% confidence interval [CI] 0.50–0.78; p &lt; 0.0001), 2.03 days shorter length of hospital stay (18 RCTs; 95% CI 1.23–2.84; p &lt; 0.00001), and a 51% reduction in the risk of sepsis (10 RCTs; RR 0.49, 95% CI 0.32–0.74; p = 0.0009). There was a non-significant 54% reduction in the 30-day mortality rate (11 RCTs; RR 0.46, 95% CI 0.20–1.08; p = 0.07) for FO-PN. FO-PN was associated with better clinical outcomes and financial savings (i.e., dominance) compared to NF-PN in all five countries studied. Conclusions: FO-PN is a cost-effective option compared to NF-PN for adult patients hospitalized in a general ward across a range of healthcare systems.

  PublisherOA PDFDOI

• Parenteral nutritional support in surgical patients: expert consensus statements regarding intravenous lipid emulsions containing omega-3 fatty acids

  Frontiers in Nutrition · 2025-02-17 · 2 citations

  reviewOpen accessSenior author

  Objectives: The International Lipids in Parenteral Nutrition (PN) Summit was convened to offer practical guidance and expert consensus opinion regarding the use of intravenous lipid emulsions (ILEs) in various clinical settings. Herein, we briefly review aspects from this summit that are of particular importance for surgical/hospitalized patients. Methods: Summit participants identified and discussed new evidence, data, and analyses, that potentially influence the benefits and risks of ILEs in PN or their use in clinical practice. The summit meeting consisted of expert presentations that assessed recent clinical data and best practice, followed by periodic panel discussions to formulate consensus statements. Consensus statements were voted on, anonymously, by the meeting attendees. Results: This review briefly summarizes the rationale for considering ILE choice as a central component of any PN strategy for surgical/hospitalized patients. Thereafter, special patient populations are considered, such as surgery-related intestinal failure, major trauma, and those with chronic critical illnesses. Expert consensus statements are also provided to help bridge the gaps between evidence and clinical practice, hence complementing formal PN societal guideline recommendations. Conclusion: The choice of ILE in PN, particularly those containing fish oil, can play a vital role in improving outcomes for surgical patients.

  PublisherDOI

• Early Restrictive vs Liberal Oxygen for Trauma Patients

  JAMA · 2025-06-05

  articleSenior author
  PublisherDOI

• Carnitine supplementation in progressive supranuclear palsy

  Nutrition in Clinical Practice · 2024-12-15

  article

  Mitochondrial dysfunction has been implicated in the pathogenesis of several neurodegenerative disorders, including progressive supranuclear palsy (PSP). PSP is a Parkinsonian syndrome characterized by a rapidly progressive state that manifests itself as tremors, bradykinesia, and supranuclear gaze palsy. Carnitine plays an essential role in mitochondrial function by transporting fatty acids across the mitochondrial membrane to be used in energy production. Mitochondrial dysfunction can bring about rapid neuronal depolarization and a calcium-mediated cellular apoptosis owing to a loss of oxidative metabolism, likely contributing to the PSP disease process. A White man aged 65 years with PSP presented with small bowel obstruction and severe malnutrition as a result of prior gastrointestinal surgeries for which a gastrostomy tube was placed. During his hospitalization, the patient was found to be deficient in both free and total carnitine. He was treated with levocarnitine supplementation and exhibited marked improvement in tremors, fatigue, and physical therapy activities. Posthospitalization follow-up showed sustained improvement in symptoms with continued levocarnitine supplementation. Treatment of PSP remains largely supportive in nature. No studies have investigated the role of carnitine supplementation in PSP. To our knowledge, this is the first case report to identify improvement in PSP symptoms after carnitine repletion and supportive care. Numerous animal studies have reported on carnitine supplementation in the context of mitochondrial dysfunction associated with neurodegenerative diseases, such as Parkinson disease and Alzheimer disease. Further investigation is necessary to elucidate the precise role of carnitine and other nutrition supplements in the pathophysiology of PSP.

  PublisherDOI

Frequent coauthors

• Lawrence Lottenberg

  St. Mary's Medical Center

  1160 shared

• Michel B. Aboutanos

  1157 shared

• Christina L. Jacovides

  University of Pennsylvania

  1156 shared

• Christ Duran

  Grant Medical Center

  1156 shared

• Eric Trevizo

  Loma Linda University Medical Center

  1156 shared

• Kevin M. Schuster

  Yale University

  1156 shared

• Thomas J. Dougherty

  Memorial Healthcare System

  1156 shared

• Tiffany J. Nevill

  John H. Stroger, Jr. Hospital of Cook County

  1156 shared