Organ aging signatures in the plasma proteome track health and disease

Nature · 2023 · 534 citations

• Biology
• Medicine
• Physiology

), the current best blood-based biomarker for AD. Our models link vascular calcification, extracellular matrix alterations and synaptic protein shedding to early cognitive decline. We introduce a simple and interpretable method to study organ aging using plasma proteomics data, predicting diseases and aging effects.

Memory failure predicted by attention lapsing and media multitasking

Nature · 2020 · 171 citations

• Computer Science
• Psychology
• Sociology

Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases

European Journal of Nuclear Medicine and Molecular Imaging · 2020 · 62 citations

• Medicine
• Neuroscience
• Pathology

Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults

eLife · 2020 · 63 citations

• Psychology
• Neuroscience

Age-related episodic memory decline is characterized by striking heterogeneity across individuals. Hippocampal pattern completion is a fundamental process supporting episodic memory. Yet, the degree to which this mechanism is impaired with age, and contributes to variability in episodic memory, remains unclear. We combine univariate and multivariate analyses of fMRI data from a large cohort of cognitively normal older adults (N=100) to measure hippocampal activity and cortical reinstatement during retrieval of trial-unique associations. Trial-wise analyses revealed that (a) hippocampal activity scaled with reinstatement strength, (b) cortical reinstatement partially mediated the relationship between hippocampal activity and associative retrieval, (c) older age weakened cortical reinstatement and its relationship to memory behaviour. Moreover, individual differences in the strength of hippocampal activity and cortical reinstatement explained unique variance in performance across multiple assays of episodic memory. These results indicate that fMRI indices of hippocampal pattern completion explain within- and across-individual memory variability in older adults.