About

Anne Ades, MD, MSEd, is a Professor of Clinical Pediatrics specializing in Neonatology and Newborn Services at the Perelman School of Medicine. She serves as the Director of the Neonatal Simulation Program within the Division of Neonatology at The Children's Hospital of Philadelphia. Dr. Ades also holds roles as an Advisory Mentor for the A-C Track at The Children's Hospital of Philadelphia, the Director of ECMO Education at the ECMO Center, and the Medical Co-Director of the Center for Simulation, Advanced Education and Innovation, as well as the Neonatal SDU Service at The Children's Hospital of Philadelphia. Her educational background includes a BS from the University of Pennsylvania obtained in 1990, an MD from Tufts University School of Medicine earned in 1995, and an MSEd from the University of Pennsylvania completed in 2014. Her work focuses on neonatal care, simulation-based education, and advanced neonatal support techniques.

Research topics

• Emergency medicine
• Medicine
• Internal medicine
• Anesthesia
• Pediatrics
• Medical emergency
• Intensive care medicine
• Psychology

Selected publications

• Variation in optimal communication modes during neonatal resuscitation

  Resuscitation Plus · 2026-03-29

  articleOpen access

  Effective communication is paramount for neonatal resuscitation. Best practices emphasize clear, coordinated team communication. High-performing teams use both routine and critical communication modes, adjusting their approach as acuity evolves. However, the degree to which interprofessional neonatal intensive care unit (NICU) teams share an understanding of when each mode is optimal is unknown. We conducted a cross-sectional study of NICU providers participating in a team-development day at a large children’s hospital. After an instructional session defining routine and critical communication, participants reviewed a hypothetical unplanned extubation and cardiac arrest scenario including 14 steps split into pre-code, code, and post-code phases. Participants rated optimal mode of team communication for each step using a 5-point Likert scale. Consensus was defined as ≥60% agreement on communication mode for each step. We compared physicians and non-physicians across scenario phases. Forty-eight providers participated, representing physicians, nurses, advanced practice providers, and respiratory therapists. Participants reached consensus on all code phase steps, selecting critical communication. No consensus was achieved for pre-code or post-code. Physicians selected more critical communication than non-physicians during the pre-code phase (median 4.0 vs 3.0, p=0.001) with no differences during code or post-code. Providers within a cohesive NICU team showed divergent mental models regarding optimal communication during early and late phases of a hypothetical resuscitation. This heterogeneity may hinder rapid team alignment and represent an important target for quality-improvement efforts. Future work should evaluate communication during real resuscitations and develop strategies to support shared communication expectations across roles.

  PublisherDOI

• A national needs assessment to inform simulation‐based education for pediatric hospital medicine

  Journal of Hospital Medicine · 2026-02-17

  articleOpen access

  BACKGROUND: Pediatric Hospital Medicine (PHM) has historically underutilized simulation-based medical education (SBME), a proven methodology for improving education and patient care. This study sought to identify and prioritize simulation-appropriate topics to inform a comprehensive PHM SBME curriculum for practicing hospitalists. METHODS: In Phase 1, local and national PHM and simulation experts generated and refined a list of potential topics, categorized into cognitive, psychomotor, and affective domains. In Phase 2, a nationally representative sample of pediatric hospitalists from the Pediatric Research in Inpatient Settings (PRIS) Network ranked their top six topics within each domain. Mean priority scores were calculated for each topic, and high-priority topics (HPTs) were identified utilizing natural breaks analysis, then expanded to balance topics across domains. RESULTS: Topic generation and expert panel refinement yielded 19 cognitive, 26 psychomotor, and 12 affective topics. These were prioritized by 52 pediatric hospitalists (of 99 [53%] surveyed). Fifteen HPTs were identified: five cognitive (respiratory distress/failure, shock, behavioral escalation, medical technology failure, sepsis), five psychomotor (lumbar puncture, bag-valve-mask ventilation, tracheostomy management, enteral tube management, chest compressions), and five affective (patient/family communication, de-escalation, interprofessional collaboration, handoffs, diagnostic error avoidance strategies) topics. Subgroup analysis revealed small variations across rater demographic characteristics. CONCLUSION: Fifteen top-rated PHM SBME topics are suitable for inclusion in a comprehensive curriculum that can be adapted at diverse institutions nationwide. Implementation may augment existing continuing medical education in PHM to help standardize care for hospitalized children.

  PublisherOA PDFDOI

• Flow disruptions during delivery room intubation of neonates with congenital diaphragmatic hernia

  Resuscitation · 2025-09-05

  article
  PublisherDOI

• Golden hour management of infants with congenital diaphragmatic hernia: 15 year experience at a high-volume center

  Journal of Perinatology · 2025-02-21 · 7 citations

  articleOpen access

  OBJECTIVE: To review the evolution of golden hour management and outcomes for infants with congenital diaphragmatic hernia (CDH). STUDY DESIGN: Retrospective single center cohort study of infants with CDH born 2008-2023 at a quaternary children's hospital. Infants were grouped into 3 epochs: 2008-2013, 2014-2018, and 2019-2023. Outcome measures included extracorporeal membrane oxygenation therapy and survival. RESULT: There were 454 infants, including 106 (2008-2013), 156 (2014-2018), and 192 (2019-2023). Despite increased disease severity, survival improved over time, from 71% (2008-2013) to 82% (2014-2018) and 83% (2019-2023), p = 0.02 for trend, with no difference in ECMO utilization. CONCLUSION: Management of infants with CDH continues to evolve with ongoing experience at our high-volume center. Despite increasing severity of illness, survival outcomes have improved over time. In the absence of clinical trial data, observational data should be evaluated rigorously to inform care in a data-driven manner.

  PublisherOA PDFDOI

• A survey of team culture and learning organization in the resuscitation of neonates with congenital anomalies: A single center experience

  Resuscitation Plus · 2025-01-24 · 1 citations

  articleOpen access

  Delivery room resuscitation of neonates with congenital anomalies is complex. This study aimed to assess survey psychometrics and measure learning organization culture among resuscitation team members in a pediatric hospital delivery room dedicated to neonates with congenital anomalies. We administered the Short-Form Learning Organization Survey with the addition of an open-ended question to all delivery room resuscitation team members from 5/2023 to 7/2023. Psychometric properties were assessed to confirm the survey’s reliability and validity in the delivery room context. Total and subscale scores were calculated, and differences were assessed by clinical role. The open-ended qualitative data were analyzed using an inductive approach and coded for theme and valence (positive, negative, neutral). The response rate was 52% (159/307) with all roles represented. Psychometric assessment produced a 25-item survey with high reliability and validity. There were no differences in total scores across roles. Nurses had higher scores compared to attending physicians ( p < 0.01) and advanced practice providers ( p < 0.05) for the supportive learning environment subscale, and advanced practice providers ( p < 0.05) for the training subscale after multiple comparisons adjustment. Qualitative analysis revealed seven themes: time constraint, environment, adequate staffing, different opinions, care deviations, leadership, and training. Valence analysis showed variation by role, with more positive nursing responses. The refined 25-item Short-Form Learning Organization Survey is a reliable and valid measure of learning organization culture for neonatal resuscitation teams. Differences in subscale scores and qualitative valence across roles highlight opportunities to improve interprofessional learning organization and team culture.

  PublisherDOI

• Observed/Expected Lung‐To‐Head Ratio and Total Lung Volumes That Identify Fetuses With Severe Congenital Diaphragmatic Hernia in a North American Fetal Center

  Prenatal Diagnosis · 2025-04-01 · 4 citations

  articleOpen access

  OBJECTIVE: To define the ultrasound observed/expected lung-to-head ratio (O/E LHR) and magnetic resonance imaging (MRI) observed/expected total lung volume (O/E TLV) cut-offs associated with survival and lack of extracorporeal membrane oxygenation (ECMO) utilization to determine the most severe cohort that may benefit from fetal intervention. METHODS: Retrospective review of patients with a prenatal diagnosis of isolated left or right congenital diaphragmatic hernia (L CDH, R CDH) seen and delivered at our level III fetal center from January 2013-July 2023. Data were extracted from our clinical outcome database. Characteristics of survivors and non-survivors were compared for both the L CDH and R CDH groups. For both O/E LHR and O/E TLV, the Youden criteria were then used to determine a good sensitivity and specificity for predicting survival and ECMO utilization for L and R CDH, respectively, in Receiver Operator Characteristic (ROC) curve analysis. RESULTS: 340 patients were included in the study, including 283 (83.2%) with L CDH and 57 (16.8%) with R CDH. The median [interquartile range, IQR] O/E LHR for L and R CDH was 37.9 [28.7-47.3] and 49.0 [40.0-64.5], respectively. The median O/E TLV for L and R CDH was 36.0 [28.0-48.0] and 25.3 [23.6-29.8], respectively. For survival, an O/E LHR of 28.1% and O/E TLV of 34.0% and an O/E LHR of 46.8% and O/E TLV of 17.6% were the best cut-offs for L and R CDH, respectively. For ECMO utilization, an O/E LHR of 32.8% and O/E TLV of 35.3% and an O/E LHR of 47.0% and O/E TLV of 22.0% were the best cut-offs for L and R CDH, respectively. CONCLUSION: We report the best ultrasound O/E LHR and MRI TLV cut-offs associated with survival and lack of ECMO utilization in our cohort.

  PublisherDOI

• Impact of a Two-Person Mask Ventilation Technique During Neonatal Resuscitation: A Simulation-Based Randomized Controlled Trial

  The Journal of Pediatrics · 2025-03-30 · 4 citations

  article
  PublisherDOI

• Fetoscopic Endoluminal Tracheal Occlusion versus Expectant Management for Severe Congenital Diaphragmatic Hernia at a Single Center

  Fetal Diagnosis and Therapy · 2025-07-04 · 1 citations

  article

  INTRODUCTION: The TOTAL trial showed survival benefit in patients with severe congenital diaphragmatic hernia (CDH) who underwent fetoscopic endoluminal tracheal occlusion (FETO). We aim to add to the current literature by describing implementation, feasibility, and outcomes of patients treated with FETO compared to a contemporary cohort of expectantly managed maternal-child dyads. METHODS: A single-center, retrospective cohort study evaluated patients with a prenatal diagnosis of isolated left-CDH with an observed/expected lung-to-head ratio (O/E LHR) <30% referred to our center from September 2016 to January 2023. RESULTS: Twelve patients who underwent FETO were compared to 35 expectantly managed patients. At initial evaluation, FETO patients had a lower O/E LHR value (21.7% versus 24.9%) compared to the expectant management patients. Chorioamniotic membrane separation occurred in half of the FETO patients (6/12) compared with 1 patient in the expectant management group and most FETO patients (75.0%) experienced preterm prelabor rupture of membranes compared to only 4 (11.4%) expectant management patients. FETO patients had a lower median gestational age at delivery compared to expectant management patients (35.0 vs. 38.9 weeks). Fewer FETO patients were treated with extracorporeal-membrane oxygenation (ECMO; 25.0% vs. 60.0% expectant management). FETO patients also had higher survival (91.7% vs. 71.4%) and longer duration of hospitalization (135 vs. 94.8 days). At time of discharge, no FETO patients required pulmonary hypertension (PH) medications while 28.0% of expectant management patients were on PH medications. CONCLUSION: FETO for severe CDH was feasible in our single center setting. FETO may increase risk of obstetric complications and prematurity, but improved ECMO use, PH, and survival of infants with severe CDH.

  PublisherDOI

• 71: Centrifugal (Spectrum) ECMO Implementation Process for Patients &lt;10kg at The Children’s Hospital of Philadelphia (CHOP)

  ASAIO Journal · 2024-09-01

  article

  Background: From May 1990 to January 2024 the platform for neonatal ECMO at CHOP was the occlusive roller pump system. Manufacturing extinction of the compliance chamber, supply chain issues with tubing packs, and oxygenators necessitated the need to transition to modern non-occlusive centrifugal technology with improved safety features. Transitioning ECMO systems can have the potential to introduce variation or risk. Neonatal-specific patient management details to prevent ECMO complications requires an understanding of the technology and management nuances. Objective/Aim: To develop safe and consistent management strategies for patients <10kg on the new centrifugal (Spectrum) ECMO platform. Methods: A multidisciplinary team met weekly and developed interventions including: an operational care workflow diagram, Epic order set updates, twice daily virtual ECMO huddles and a weekly data monitoring safety analysis review. Educational support included didactic and simulation training. Feedback was collected from ECMO huddle participants to inform improvements. Results: Team review of seven patients’ runs was completed during the transition to identify process vulnerabilities. Six care process modifications were employed to enhance monitoring and decision support. 100% of ECMO huddle feedback respondents (N=34) rated huddles as having some (23%) or great (77%) value. Conclusion: A multidisciplinary team was necessary for comprehensive identification and implementation of novel patient management strategies. The interventions implemented by the project team and ongoing Spectrum clinical support continues to foster safe practice. Next steps include increased exposure, continued standardization of centrifugal management and census review to further improve care for ECMO patients <10kg.

  PublisherDOI

• Post-resuscitation care in the NICU

  Seminars in Perinatology · 2024-10-09 · 1 citations

  reviewSenior author
  PublisherDOI

Frequent coauthors

• Taylor Sawyer

  Seattle University

  72 shared

• Elizabeth E. Foglia

  Children's Hospital of Philadelphia

  65 shared

• Akira Nishisaki

  University of Pennsylvania

  41 shared

• Lindsay Johnston

  Yale University

  38 shared

• Vinay Nadkarni

  Children's Hospital of Philadelphia

  38 shared

• Natalie E. Rintoul

  Children's Hospital of Philadelphia

  35 shared

• Jack Rychik

  University of Pennsylvania

  35 shared

• Holly L. Hedrick

  Children's Hospital of Philadelphia

  28 shared

Education

• B.S.

  University of Pennsylvania

  1990

• M.D.

  Tufts University School of Medicine

  1995

• Other

  University of Pennsylvania

  2014